Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study

Abstract

Objectives

Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults.

Design

We conducted a population-based matched cohort study with a 13.8-year follow-up.

Setting

A baseline questionnaire was completed by participants in 1997 and follow-up data were extracted from the national hospital discharge registry of the National Institute for Health and Welfare in Finland from 1997 to 2014.

Participants

A total of 1394 adults with asthma were matched with 2398 adults without asthma based on sex, age and area of residence. Asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right resulting from asthma. Participants without asthma were identified from the Population Register.

Main outcomes and measures

Oral health-related primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition and divided into groups of diseases. Cox’s proportional hazards models stratified by matching unit and models matched and adjusted for pack-years, education level and body mass index (when possible) were used to evaluate the matched and further adjusted HRs for diseases comparing asthmatic and non-asthmatic cohorts.

Results

Adult asthma was associated with a higher risk for any oral-manifesting disease (adjusted HR 1.41, 95% CI 1.11 to 1.80), herpes zoster (adjusted HR 6.18, 95% CI 1.21 to 31.6), benign tumours of the oral cavity and pharynx (matched HR 1.94, 95% CI 1.05 to 3.56) and dermatological diseases (pemphigus, pemphigoid, dermatitis herpetiformis, psoriasis and lichen planus, HR 1.67, 95% CI 1.01 to 2.78).

Conclusions

In this study, adult asthmatics experienced a higher risk for a major oral disease or oral-manifesting disease.

Strengths and limitations of this study.

• This study is a population-based, matched cohort design with a nearly 14-year follow-up.

• A detection bias was possible given the more intensive use of healthcare services among asthmatics (and people with any moderate to severe chronic disease) compared with non-asthmatics, potentially impacting the results.

• The possible causal relationship between asthma and oral health conditions may be confounded by asthma medications, which decrease salivary flow and lower the pH in the oral cavity.

• An asthma diagnosis was confirmed by a medical doctor and based on lung function tests and typical medical history.

• The study lacks data from primary care, where common dental or oral problems, such as periodontitis or oral candidiasis, are typically treated.

Introduction

Asthma is one of the most common chronic diseases in children and adults, recognised for its characteristic pattern of symptoms, such as its timing, triggers and response to treatment. Typical symptoms include wheezing, shortness of breath, chest tightness and a cough, yet a careful patient history remains crucial for the differential diagnosis. The prevalence of asthma in adults ranges from 0.2% to 21.0%, remaining highest in developed countries and most likely underestimated in poorer countries.¹ In addition to socioeconomic class and a genetic predisposition, megatrends such as climate change, ageing and urbanisation impact asthma prevalence.^2–4 While asthma has been considered a single disease, recent studies have shown that it consists of multiple phenotypes.⁵ Furthermore, asthma varies considerably across a patient’s life, presenting differently in adults vs children. Where childhood asthma is characterised by a predominance of allergic multimorbidity and a higher prevalence among boys, adult asthma is associated with more respiratory symptoms and asthma medications.⁶ Risk factors for adult asthma consist of a genetic predisposition, female gender, overweight, allergies, upper airway diseases and exposure to tobacco smoke or other irritants.⁷ The primary adult asthma phenotypes identified thus far include (1) early-onset allergic asthma, (2) early-onset allergic moderate-to-severe remodelled asthma, (3) late-onset no-nallergic eosinophilic asthma and (4) late-onset non-allergic non-eosinophilic asthma, whereby an overlap of commonly reported asthma phenotypes has also been observed carrying implications for objective asthma outcomes.^{5 8} Furthermore, the definition of ‘early onset’ varies across studies. For instance, a study investigating severe asthma subgroups defined late-asthma onset as occurring after the age of 12 years,⁹ while other studies refer to early-onset adult asthma when asthma onset was reported at 12–15 years.¹⁰ More severe forms of adult asthma appear less stable than childhood-onset disease with more relapses and less remission, and have been associated with an increased IgE, eosinophilia, poorer adherence to therapy, recurrent infections, obesity, smoking and a lower socioeconomic status.^{1 6} Various classifications and subgroups of asthma phenotypes have been proposed, but a clear consensus has not yet emerged within the scientific community. The heterogeneity of severe asthma phenotypes has resulted in the development of new asthma treatments targeting specific immune pathways, with perhaps a limited utility among the general asthma population, but carrying a potential benefit to a subset of asthma patients.¹¹

Studies have demonstrated that many comorbidities coexist with asthma, possibly even contributing to a lower life expectancy.¹² We previously detected an increased all-cause mortality among asthmatics in the Finnish adult population, largely explained by the development of chronic obstructive pulmonary disease in smoking asthmatics, malignant respiratory tract neoplasms and cardiovascular diseases.¹³ In the Finnish population, the most common comorbidities of adult asthma consist of hypertension, diabetes, severe psychiatric disorders and ischaemic heart disease.¹⁴ Other known asthma-related comorbidities include rhinitis, chronic sinusitis, gastro-oesophageal reflux disease, obstructive sleep apnoea, hormonal disorders, obesity, hyperventilation, glottic dysfunction and respiratory infections.¹⁵ In a population-based cross-sectional study covering 1.4 million Scottish patients, comorbidities associated with asthma in adults included chronic obstructive pulmonary disease, bronchiectasis, eczema/psoriasis, dyspepsia, depression and anxiety.¹⁶

Asthma was previously associated with herpes zoster, tooth decay, dental erosion, oral candidiasis, periodontal disease, psoriasis and gastro-oesophageal reflux disease.^16–25 A cross-sectional, self-reported study investigated the association of oral health and asthma/allergic rhinitis/atopic dermatitis in a large population of Korean adolescents over a 12-month period.²⁶ Poor oral health was significantly correlated with the prevalence of asthma/allergic rhinitis/atopic dermatitis. That study benefited from a large sample of over 130 000 participants, although the assessment of causality was limited due to its cross-sectional design.²⁶ The oral cavity is closely connected with the lower airways given the anatomical location and in terms of functions such as conducting and modifying inhaled air and speech. A recent review outlined one theory suggesting that the lung microbiota results from the random immigration of bacteria originally from the oral microbiota, random bacterial reproduction in the lung and the random exclusion of lung bacteria.²⁷ That same review suggested that associations between asthma and oral health are explained by asthma medications, mainly β₂-agonists and inhaled steroids. Specifically, asthma inhalers decrease saliva production and its components, which protect and rinse the oral cavity and teeth. They also contain sugary components and create a pH <5.5, thus inducing dental caries and erosion.^{27 28} The direct effects of asthma on periodontal health may involve dehydrating the alveolar mucosa due to mouth breathing, and altering the immune response via an increased concentration of IgE, which may cause periodontal destruction.^{25 29} Furthermore, obesity is a major risk factor for asthma, and closely connected to overeating and the high consumption of sweet foods and drinks, possibly leading to poor oral health.^{25 30}

Study aim

This cohort study aimed to investigate the hazard rate of major oral-manifesting diseases in asthmatic adults compared with non-asthmatic adults. We hypothesised that asthmatics experience more major oral diseases than non-asthmatics.

Methods

Study design

This population-based, matched cohort study with follow-up began with a questionnaire completed in 1997, which collected data from asthmatics and matched non-asthmatics on their living environment, allergies, smoking duration and quantity, weight and education level. The questionnaire was sent to 4958 individuals, 3792 of whom responded. Altogether, this study consisted of 1394 asthmatics and 2398 adults without asthma. Follow-up data including all diagnostics codes for the participants who responded were collected from the national hospital discharge registry of the National Institute for Health and Welfare from 1997 to 2014.

Patient and public involvement

Study participants were not involved in planning the study design. Extended data from the registers were collected with approval from the National Institute for Health and Welfare. Study results have been published only in peer-reviewed journals, with no other information related to the results provided to participants.

Study population

Participants with and without asthma were matched based on sex, age (±2 years) and area of residence by postal code. A total of 1400 asthmatic adults were identified from the Drug Reimbursement Register of the Finnish Social Insurance Institution based on a special drug reimbursement right due to an asthma diagnosis. The population register was used to identify 2800 matched non-asthmatics. In total, 248 asthmatics and 511 non-asthmatics were recruited from the Mini Finland Health Survey.³¹ All asthmatics fulfilled the criteria for physician-diagnosed asthma, criteria which included a typical history, clinical features and asthma course and lung function tests. Participants were over 30 years old (table 1), nearly 62% were male and 38% women. An estimate of participants’ lifetime tobacco exposure at baseline was calculated in pack-years.³² The body mass index was grouped according to four categories, while level of education was divided into three categories based on the Finnish education system. The study population was described in further detail elsewhere.¹³

Table 1.

Baseline characteristics collected from Finnish patients via questionnaire in 1997

	No asthma, n (%)	Asthma, n (%)	Missing (%)
Sex
Men	912 (38.0)	532 (38.2)
Women	1486 (62.0)	862 (61.8)
Total	2398	1394
Age at baseline (in years)
≤59	1506 (62.8)	893 (64.1)
60–69	699 (29.1)	401 (28.8)
70–79	166 (6.9)	84 (6.0)
≥80	27 (1.1)	16 (1.1)
Pack-years			6.7
0	1286 (57.1)	625 (48.6)
≤19	595 (26.4)	389 (30.2)
≥20	371 (16.5)	273 (21.2)
BMI (kg x m -2)			2.4
Underweight (<18.5)	26 (1.1)	19 (1.4)
Normal (18.5–24.99)	998 (42.6)	463 (34.0)
Overweight (25–29.99)	958 (40.9)	577 (42.4)
Obese (≥30)	358 (15.3)	303 (22.2)
Education level			2.2
Matriculation exam	435 (18.5)	187 (13.8)
Secondary school	560 (23.8)	322 (23.7)
Primary school or less	1356 (57.7)	850 (62.5)

Lifetime tobacco exposure was calculated in pack-years (number of cigarettes per day/20×number of years smoked, where 1 pipe=2.5 cigarettes and 1 cigar=4 cigarettes) on which individuals were divided into three groups: 0, ≤19 and ≥20 pack-years.

BMI assessed as weight in kilograms divided by the square of the height in metres, then divided into four categories according to WHO classification.

Level of education was obtained through a questionnaire and categorised based on the Finnish education system: matriculation examination (13 years, reference value), secondary school or equivalent (9 years) and primary school or less (≤6 years).

BMI, body mass index.

Outcomes

In this study, we focused on oral diseases and diagnoses that can manifest in the oral cavity. The diagnoses were identified from hospital visit and hospitalisation data obtained from the national hospital discharge registry of the National Institute for Health and Welfare from 1997 to 2014. Only the primary diagnoses were retrieved using codes from the International Classification of Diseases, 10th edition (ICD-10), and were divided into five disease groups: infections, malign neoplasms, benign neoplasms, dental diseases and dermatological diseases. The first group consisted of viral and fungal infections (herpes simplex (B00.1); herpes zoster (B02); hand, foot and mouth disease (B08.4); herpangina (B08.5); HIV disease resulting in candidiasis (B20.4); Kaposi sarcoma (B21.0); Burkitt lymphoma (B21.1); mumps (B26.9); Epstein-Barr (B27.0); candidiasis (B37); and tonsillar aspergillosis (B44.2). Malign neoplasms consisted of malignant neoplasms of the lip, oral cavity and pharynx (C00–C14); malignant melanoma of the lip (C43.0) and basal cell carcinoma of the lip (C44.0). Benign neoplasms included benign tumours (D00.0, D03.0 and D03.3), in situ neoplasms (D23.0) and other benign neoplasms of the lip, oral cavity, pharynx or bone of the skull and face (D10, D11, D16.4, D16.5 and D37.0). Dental diseases included diseases of the oral cavity, salivary glands and jaws (K00–K14). The last group included dermatological diseases (pemphigus L10), pemphigoid (L12), dermatitis herpetiformis (L13.0), psoriasis (L40) and lichen planus (L43).

We used a 1-year wash-out period from the beginning of follow-up in 1997 to identify and exclude those with a pre-existing disease of interest. For each outcome of interest, those eligible for follow-up (eg, individuals without diagnoses during the wash-out period) were followed up until the first occurrence defined as the first hospital visit/hospitalisation with a diagnosis of interest, death or the end of follow-up (31 December 2014). Therefore, each diagnosis was recorded only once.

Statistical analyses

We assessed and reported the incidence of the diseases of interest. Cox proportional hazards models stratified by the matching criteria (sex, age and area of residence by postal code) and models matched and adjusted for smoking, education level and body mass index (when possible) were used to evaluate the matched and additionally adjusted HRs for diseases comparing asthmatic and non-asthmatic individuals. We modelled each comorbidity separately. The differences in comorbidity-free survival between asthmatics and non-asthmatics were also assessed by plotting the Kaplan-Meier survival curves and performing log-rank tests. In all analyses, we considered p<0.05 statistically significant. All data analyses were performed using the R statistical software package, V.3.6.1.³³

Results

The mean follow-up period was 13.8 years. A total of 58 113 person-years accumulated for 3792 individuals. Overall, 71% of asthmatic patients used inhaled corticosteroids and 76% used any inhaled asthma medication at baseline (in 1997). The risk of experiencing any oral health-related disease (including all diseases investigated) was higher among asthmatics (matched HR 1.61, 95% CI 1.24 to 2.10, p<0.001, table 2), with the Kaplan-Meier plot (figure 1) showing a clear difference between asthmatics and non-asthmatics individuals. These results remained significant after adjusting for pack-years, education level and body mass index (HR 1.41, 95% CI 1.11 to 1.80, p=0.001).

Table 2.

Comparison of Finnish non-asthmatic and asthmatic adults for oral comorbidities, 1997–2014

		10 000 person-years	Events	Rate (95% CI) per 10 000 person-years	Matched HR (95% CI)	Adjusted HR (95% CI)
Any oral disease	No asthma	33.46	165	4.93 (4.21 to 5.74)	1	1
	Asthma	18.41	136	7.39 (6.20 to 8.74)	1.61 (1.24 to 2.10)	1.41 (1.11 to 1.80)*
Herpes zoster	No asthma	34.72	4	0.11 (0.03 to 0.29)	1	1
	Asthma	19.51	14	0.72 (0.39 to 1.20)	6.94 (1.50 to 32.1)	6.18 (1.21 to 31.6)†
Malign neoplasms	No asthma	34.66	11	0.32 (0.16 to 0.57)	1	1
	Asthma	19.52	13	0.67 (0.35 to 1.14)	2.33 (0.91 to 5.99)	2.13 (0.72 to 6.34)†
Benign neoplasms	No asthma	34.53	28	0.81 (0.54 to 1.17)	1	1
	Asthma	19.41	25	1.29 (0.83 to 1.90)	1.94 (1.05 to 3.56)	1.64 (0.81 to 3.33)‡
Dental diseases	No asthma	34.02	96	2.82 (2.29 to 3.45)	1	1
	Asthma	19.03	66	3.47 (2.68 to 4.41)	1.21 (0.84 to 1.73)	1.40 (0.93 to 2.12)††
Dermatological diseases	No asthma	34.35	42	1.22 (0.88 to 1.65)	1	1
	Asthma	19.19	36	1.88 (1.31 to 2.60)	1.67 (1.01 to 2.78)	1.72 (0.85 to 3.47)*

HR based on Cox proportional hazards regression models. In the first model, matching is considered as strata. The second model is matched and adjusted based on background variables.

Matched HR, participants with asthma and without asthma are only matched for sex, age and area of residence by postal code.

Bold values denote statistical significance at the p<0.05 level.

Adjusted HRs.

*Matched for sex, age and area of residence by postal code and adjusted for pack-years, education level and body mass index.

†Matched for sex, age and area of residence by postal code and adjusted for pack-years.

‡Matched for sex, age and area of residence by postal code and adjusted for pack-years and education level.

Figure 1.

Kaplan-Meier survival curve of the difference in oral health-related diseases among asthmatics and non-asthmatics. P value for the log-rank test.

Only a few cases of candidiasis and herpes simplex infections were recorded in the infections group. Since these cases primarily consisted of herpes zoster, we calculated the HR for herpes zoster cases only. We found that the rate of herpes zoster was nearly seven times higher in the asthmatic group (matched HR 6.94, 95% CI 1.50 to 32.1, p<0.05) compared with non-asthmatics. After adjusting for pack-years, this association persisted (adjusted HR 6.18, 95% CI 1.21 to 31.6, p<0.05). Benign tumours were 1.5-fold more frequent among asthmatics (matched HR 1.94, 95% CI 1.05 to 3.56, p<0.05). The most common benign tumours in the head area included neoplasms of the inner mouth and tumours of the parotid gland and other major salivary glands.

Asthma was not significantly associated with an increased risk for malignant neoplasms of the lip, oral cavity or pharynx (matched HR 2.33, 95% CI 0.91 to 5.99, p=0.080). Cancers of the lip, oral cavity or pharynx as well as melanoma or basal cell carcinoma of the lip were recorded. The risk for of non-neoplastic conditions of the head and neck region, in addition to diseases of the oral cavity, salivary glands and jaws was not significantly higher among asthmatics (HR 1.21, 95% CI 0.84 to 1.73, p=0.059). Similarly, dental diseases such as caries, chronic apical periodontitis and periapical abscess taken together were not significantly associated with adult asthma neither in a univariate analysis (matched HR 1.21, 95% CI 0.84 to 1.73, p=0.307) nor after adjustment (HR 1.40, 95% CI 0.93 to 2.12). A higher risk for dental caries on its own emerged among adult asthmatics (matched HR 2.13, 95% CI 0.90 to 5.05, p=0.085) but the association was not statistically significant.

Finally, we examined dermatological diseases that may have oral manifestations, finding that the investigated diseases associated with asthma in the matched cohort (matched HR 1.67, 95% CI 1.01 to 2.78, p=0.048). However, after adjusting for pack-years, education level and body mass index, the association diminished (adjusted HR 1.72, 95% CI 0.85 to 3.47, p=0.129). Psoriasis and lichen planus were the most common skin diseases representing 89% of all skin diseases examined among asthmatic adults (table 3). Furthermore, among adults without asthma, psoriasis and lichen planus comprised 77% of all skin diseases investigated in this study. Other dermatological diseases identified included pemphigus, pemphigoid and dermatitis herpetiformis.

Table 3.

Frequency of oral diagnoses during follow-up, 1997–2014

	No asthma	Asthma
Virus infections
Herpes zoster (B02)	4	14
Other infections (B00, B37)	3	1
Oral cancer
Lip, oral cavity and pharynx (C00–C02, C04, C10, C13, C14)	7	11
Melanoma or basal cell carcinoma of lip (C44)	4	3
Benign tumours
Mouth and pharynx (D10)	14	16
Major salivary glands (D11)	8	8
Other benign tumours (D03, D23, D37)	7	2
Dental diseases	16	21
Dental caries (K01, K02)
Diseases of the salivary glands (K11)	16	15
Stomatitis and related lesions (K12)	6	5
Diseases of the lip and oral mucosa (K13)	17	8
Diseases of the tongue (K14)	8	5
Other dental diseases (K03, K04, K10)	33	14
Dermatological diseases
Psoriasis (L40)	21	22
Lichen planus (L43)	13	12
Pemphigus (L10)	1	0
Pemphigoid (L12)	4	3
Dermatitis herpetiformis (L13.0)	5	1

Discussion

In this population-based, cohort study, asthmatics carried a higher risk of experiencing an oral-manifesting disease. The differences in the risks for infections, benign neoplasms and dermatological diseases contributed to the overall increase. The risk for benign oral tumours (including benign salivary gland tumours) was 1.5-fold higher, while the risk for a viral infection, specifically, herpes zoster, was nearly seven times higher among asthmatic adults compared with non-asthmatic adults. Dermatological diseases, mainly psoriasis and lichen planus, associated with asthma in the matched cohort, although the risk was not significant in the adjusted model.

We observed an increased risk for herpes zoster among asthmatic adults. An 8-year follow-up study conducted in Taiwan among over 40 000 newly diagnosed, adult asthmatics compared with age-matched and sex-matched non-asthmatics found that the risk of herpes zoster was 1.48-fold higher in asthmatics.³⁴ A meta-analysis of 12 studies investigating the relationship between asthma and herpes zoster found that asthma was associated with a greater risk (risk ratio 1.24, 95% CI 1.16 to 1.31, p<0.0001) of infection.³⁵ Herpes zoster infection in the intraoral region classically presents as a unilateral dermatomal rash with a maculopapular appearance, preceded with hard, neuropathic pain.^{36 37} Caused by the reactivation of varicella zoster virus, herpes zoster may occur spontaneously or due to an immune system deficiency. Respiratory viruses associated with asthma exacerbations include respiratory syncytial viru, influenza viruses and human rhinoviruses, as well as coronaviruses, parainfluenza viruses, adenoviruses and, more recently, metapneumoviruses and bocaviruses.^{38 39} Presumably, an age-related decline in immune function and a coexisting viral infection promotes persistent chronic inflammation of the airways.⁴⁰

We previously found that a higher all-cause mortality among adult asthmatics was largely explained by the development of chronic obstructive pulmonary disease, malignant respiratory tract neoplasms and cardiovascular diseases.¹³ Although highly lethal in general, we detected no increased mortality resulting from oral cancer among asthmatics in our previous study, presumably due to its low incidence compared with other causes of death among both asthmatics and controls. In agreement with our previous findings, asthma did not significantly associate with malignant neoplasms of the oral cavity or pharynx in the study reported here.

Our results suggest that the risk of benign oral tumours could be higher among asthmatic adults compared with non-asthmatic adults. To our knowledge, this represents the first study to examine the association between benign oral tumours and asthma. Over 30% of the benign tumours among asthmatics consisted of salivary gland tumours. While the cause of salivary gland tumours remains unknown, autoimmune conditions such as diabetes and Sjögren’s syndrome are associated with salivary gland swelling.⁴¹ We suspect that the increased risk associated with benign oral tumours is explained by a combination of autoimmune dysfunction, decreased salivary flow (due to the use of β_2-agonists) and a detection bias resulting from the overdiagnosis of benign tumours among asthmatics, individuals who consult healthcare services more frequently.

Furthermore, we found that dental diseases (diseases including tooth decay, chronic apical periodontitis, sialadenitis and diseases of periodontal tissue) were not significantly associated with adult asthma. It is widely acknowledged that asthma medication, especially the immunosuppressive effects of inhaled corticosteroids, promote oral candidiasis and tooth decay.²⁵ According to a meta-analysis and systematic review of 18 studies, asthma roughly doubles the risk of dental caries in both primary and permanent dentition.¹⁷ Plausible mechanisms contributing to tooth decay include decreased saliva secretion and a lower salivary pH due to inhaled β₂-agonists and corticosteroids as well as dry powder inhalers containing lactose monohydrate, and an increase in Lactobacilli and Streptococcus mutans in the oral cavity.^{17 21} An increased risk for caries might also stem from the decreased biodiversity in the oral cavity and an aberrant immunity among asthmatics.

The data used in this study were collected from the national hospital discharge registry of the National Institute for Health and Welfare in Finland, which collects data from hospital and health centres. The dental or and/oral diagnoses in this study result from dental specialists working in specialised healthcare settings. The National Institute for Health and Welfare of Finland began collecting outpatient data from public health services (such as data from dental examination) in 2011, and the initial years of data collection featured poor-quality data. Therefore, our data do not include oral status information routinely collected by dentists in primary care settings, and we cannot draw any conclusions about the incidence of, for example, tooth decay from these data. Additionally, oral candidiasis is presumably common among patients using inhaled corticosteroids. However, due to its mild symptoms, the condition often remains undiagnosed. In our study, only a few cases of oral candidiasis were recorded. Thus, a causal relationship between inhaled asthma medications and oral candidiasis could not be examined from these data.

In our study, dermatological diseases with potential oral manifestations were more common among asthmatics. Psoriasis is an immune-mediated, genetic skin and joint disease typically characterised by erythematosus plaques with silvery scales.²³ A recent meta-analysis indicated that patients with psoriasis carry an increased risk for asthma, particularly older patients.²² Furthermore, oral manifestations of psoriasis include lesions of small, whitish papules, red and white plaques that follow skin lesions and bright red patches, all of which may also be associated with angular cheilitis, geographic tongue lesions and a fissured tongue.⁴² Whether psoriasis can manifest solely in the oral mucosa has been a matter of debate for years. The benefits of our relatively large, matched-cohort design used in this study allowed us to also detect associations between rare diseases such as autoimmune diseases.

Based on genome-wide association studies, both asthma and autoimmune diseases are associated with several single-nucleotide polymorphisms in the human 17q12-21 locus.⁴³ Although rare and difficult to diagnose, some case reports suggest that an intraoral form of psoriasis exists.⁴⁴ Moreover, studies have shown shared genetic variants of asthma and autoimmune diseases,⁴ possibly reflecting an increased co-existence of asthma and psoriasis compared with controls. Asthma and psoriasis also share certain comorbidities such as cardiovascular diseases, depression, diabetes and obesity.⁴⁵

In line with our findings for psoriasis, another autoimmune disease, lichen planus, emerged as one of the most common dermatological diseases among asthmatics in our study. The clinical features of oral lichen planus typically include pain and burning in the mouth induced by spicy or acidic foods due to lesions in the mucosa. Clinical presentations of oral lichen planus consist of reticular, erosive, plaque-like and bullous lesions, which can occur individually or in combination. Frequently asymptomatic, reticular oral lichen planus is, however, the most common type of lichen planus.⁴⁶ To our knowledge, no previous studies examined the association between lichen planus and asthma.

This study has several strengths and limitations. The strengths of this study include the population-based, matched-cohort design and the inclusion of asthma diagnoses confirmed through lung function tests. This study also benefits from its long follow-up period. Conversely, one limitation to this study stems from the lack of primary care data, from which typical dental problems such as dental caries are normally treated. We also note that the possible causal relationship between asthma and oral health conditions may be confounded by asthma medications. Medications commonly used to treat asthma, such as β₂-agonists and inhaled steroids, may promote caries, dental erosion, periodontal disease, erosion and oral candidiasis.²⁵

We calculated HRs to measure the difference between asthmatic and non-asthmatic patients. However, using HRs, roughly interpreted as the incidence rate ratio, is not completely unproblematic. The use of HRs to indicate a causal relationship is risky for two reasons: first, HR may change over time and, second, HR has a built-in selection bias.⁴⁷ We acknowledge the possibility of a detection bias due to the more intensive use of healthcare services by asthmatics (and people with any moderate to severe chronic disease) than non-asthmatics, potentially affecting our results. For some comorbidities, uncertainty (wide CIs) regarding the magnitudes of the observed relative differences and a limited statistical power precluding any potentially existing associations should be considered when interpreting our results.

Finally, one of the most common oral health problems, periodontitis, carries a two-way relationship with diabetes mellitus, and is presumably associated with severe asthma in adults.^{48 49} Periodontitis is diagnosed and primarily treated in primary care settings. The incidence of this chronic inflammatory disease of the tissue surrounding the teeth thus cannot be investigated with this dataset. The clinical features of cases were not available given the register-based study design. In cases of herpes zoster and psoriasis, ICD-10 codes do not distinguish between anatomical sites of disease manifestation. However, to our knowledge, the incidence of oral manifestations of these diseases remains unclear, and is therefore important to take into account for each case.

Conclusions

Adult asthmatics experience a higher risk for an oral-manifesting disease. Viral and fungal infections represented the most common oral disease among asthmatics, while the risk for a benign tumour or dermatological disease was also higher among adult asthmatics. Identifying the most common asthma-related oral diseases may result in an early diagnosis and better management of comorbid conditions as well as the overall health of asthmatics. As such, dental professionals are an important part of healthcare teams given their expertise in detecting abnormalities in the oral cavity of asthmatic patients.

Data availability statement

No data are available. The data that support the findings of this study areavailable from Statistics Finland and the the National Institute for Health and Welfare, but restrictions apply to the availability of these data, which wereused under licence for the current study, and so are not publicly available. Data are, however, available from the authors on reasonable request and with permission ofStatistics Finland and the National Institute for Health and Welfare.

Ethics statements

Patient consent for publication

Not applicable.

Ethics approval

Approval for the study was obtained from the ethical committee at Tampere University Hospital (R15030) and written informed consent was obtained from all subjects.