Supplementary Figure 1.

(A) Kaplan-Meier curve of disease-specific survival stratified by recurrence pattern in all 3 cohorts (total n = 1087). Only those with recurrent disease (n = 704) are shown. (B) Proportion of each recurrence pattern in patients with classical and squamous subtype. Squamous subtype enriched for liver recurrence (P < .001); classical subtype associated with lung recurrence (P = .007). Bar chart demonstrates the relative proportions of each molecular subtype in different recurrence patterns. Proportion is based on the frequency of each recurrence pattern per molecular subtype. (C) Proportion of gene mutations in each recurrence pattern. P value calculated using chi-square. (D) Table of significantly mutated gene analysis in recurrence patterns. A significant q value (<0.05) represents an association between mutation and recurrence pattern. Only BRAF (liver) and RNF43 (no recurrence) were significant in specific recurrence patterns. (E) Table of clinical, molecular, and pathologic features of RNF43 mutants in analyzed cohort.