Supplementary Figure 2.

(A) Table demonstrating frequency of KRAS allelic imbalance and whole genome doubling in recurrence patterns of PCAWG cohort. (B) Transcriptional modules defined as significant by Bailey et al⁴ in each recurrence group for patients with RNA sequencing data. Significant modules that are associated with recurrence patterns are highlighted with black arrow on left y-axis. Key processes and gene programs previously described by Bailey et al⁴ that define squamous and classical pancreatic (pancreatic progenitor, immunogenic, ADEX) subtypes are highlighted along right-hand y-axis. (C) Relative enrichment score of genes associated with recurrence pattern in each module that associated with recurrence pattern, from the APGI microarray cohort. Statistical significance levels are ∗≤.05, ∗∗≤.01, ∗∗∗≤.001, and ∗∗∗∗≤.0001 with the first given recurrence pattern as reference (for example, for green, yellow, and orange modules the reference is liver, for light yellow it is local, and for turquoise and grey 60 the reference is lung).