In the original article, there was a mistake in the legend for Figure 1 as published. The stated DC-AT was a mistake. The correct legend appears below.
Figure 1.
Prepared cytokine-induced killer (CIK) cells mainly consist of activated T cells and CD8+Tcm by flow cytometry. (A) The plots of flow cytometry data of activated T cells and CD8+Tcm in PBMCs and prepared CIK cells, respectively. (B) Compared with PBMCs, the percentage of CD8+CD38+HLA-DR+ cells was increased largely in CIK cells (n = 26, in CIK, 52.62 ± 13.53%; in PBMC, 18.35 ± 10.46%, **P < 0.01). Moreover, the percentage of CD8+CD45RO+CD62L+ cells in the CIK cells was increased to a high level after incubating for 12 days (n = 26, in CIK, 42.18 ± 9.87%; in PBMC, 21.37 ± 12.73%, *P < 0.05), indicating prepared CIK cells had been activated in vitro and had superior antitumor potential.
In the original article, there was a mistake in Figure 5C as published. Another figure was mistakenly used when arranging Figure 5C . The corrected Figure 5 appears below.
Figure 5.
Cytokine-induced killer (CIK) cells combined with 3,4-methylenedioxy-β-nitrostyrene (MNS) showed superior antitumor potential for pancreatic cancer in vivo. (A) 1 ×106 SW1990 cells were suspended in 100 μl serum-free RPMI 1640 and subcutaneously injected into the left upper flank of each mouse (female BALB/c-nu/nu, 4–6 weeks old). Two weeks after the cell injection, in the setting of observable tumors, mice were randomly allocated to the MNS group, which only received an MNS (20 mg/kg body weight) injection intraperitoneally, the CIK group, which only received a 100 μl CIK cell injection intravenously, the MNS+CIK combined treatment group which was simultaneously treated with intraperitoneal MNS (20 mg/kg body weight) and intravenous CIK cells (100 μl), and the control group which received 200 μl of vehicle. (B) Tumor volumes were measured before each injection, which were calculated as described: V (cm3) = width2 (cm2) × length (cm)/2. Tumor growth curves showed that the average volume of tumors in the MNS+CIK group was significantly smaller compared to the control group and both single-treatment groups (P < 0.05). (C) Representative immunohistochemical analysis of tumor samples showed that expression of NLRP3 inflammasome and interleukin (IL)-1β were inhibited in the MNS+CIK group.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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