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. 1965 Mar 1;6(1):249–260. doi: 10.1186/BF03547082

Passage of I131-Albumin and I125-Gamma Globulin Into the Small Intestine of Calves

Der intestinale Durchtritt von J131-Albumin und J125-Gammaglobulin

Udskillelse af J131-albumin og J125-gammaglobulin til tyndtarmen hos kalve

Knud Nielsen 1,✉, John Dich 1
PMCID: PMC8741092  PMID: 4158732

Abstract

Intestinal transfer of I131-albumin and I125-gamma globulin was studied in 5 calves fitted with re-entrant intestinal loops. The passage of the two proteins across the intestinal wall proved highly variable (cf. Table II). However, the transfer of I131-albumin and I125-gamma globulin was of the same order of magnitude, which is taken as evideńce of similar transfer mechanisms of albumin and gamma globulin, in spite of different molecular weights. Instillations of hypertonic magnesium sulphate solution and of intestinal digesta were followed by increased transfer rates. It appears, therefore, that the passage of digesta will influence the transfer of proteins along the gut. It is emphasized that quantitation of the transfer as related to total catabolism of plasma proteins is subject to considerable inaccuracy.

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Footnotes

This investigation was aided by a grant from Statens almindelige Videnskabsfond

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