Figure 6.

NR modestly increases energy expenditure wild-type C57BL6/NJ mice without impacting glucose tolerance when NR is administered at the onset of a high-fat diet

(A) Experimental design for the prevention cohort.

(B) Growth curve.

(C) Body composition at 8 and 18 weeks post HF or HF + NR diet.

(D) Energy expenditure in the fed state monitored over 24h at 10 and 16 weeks post HF or HF + NR diet.

(E) Oral glucose tolerance.

(F) 5h fasting insulin at 15 weeks post HF or HF + NR diet. Data are represented as mean ± SEM.

(A–F) N = 10 per group. Data were analyzed by two-tailed student's t-test. ∗ represents a significant difference between HF- and HF + NR-fed mice. ∗P≤0.05. N represents biological replicates.

See also Figure S7.