Abstract
The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O2 gas mixture relieved manifestations of ventilation insufficiency and increased SpO2 and pneumatization of the terminal parts of the lungs.
Key Words: post-COVID complications, Хе, pulmonary surfactant, dipalmitoylphosphatidylcholine, molecular electrostatic potential
Footnotes
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 362-366, September, 2021
References
- 1.Vinokurov AS, Zyuzya YuR, Yudin AL. Evolution of follow up ct signs in patients with COVID-19 in early stage. Luch. Diagnost. Ter. 2020;11(2):76-88. 10.22328/2079-5343-2020-11-2-76-88. Russian.
- 2.Temporary Guidelines. Prevention, Diagnosis, and Treatment of New Coronavirus Infection (COVID-19). Ver. 11, May 2021 [URL: https://edu-rosminzdrav.ru.com/profilaktika-diagnostika-i-lechenie-covid-19/]. Russian.
- 3.A Method for the Correction of Acute and Chronic Stress Disorders Based on Inhalation of Therapeutic Doses of Medical Xenon Brand KseMed. Medical technology. Federal Service for Surveillance in Healthcare Approval No. FS 2010/227 from June 17, 2010. Russian.
- 4.The Use of Oxygen-Xenon Mixture for Pain and Pain Syndromes. Federal Service for Surveillance in Healthcare Approval No. FS 2010/123 from April 2, 2010. Russian.
- 5.Barker-Davies RM, O’Sullivan O, Senaratne KPP, Baker P, Cranley M, Dharm-Datta S, Ellis H, Goodall D, Gough M, Lewis S, Norman J, Papadopoulou T, Roscoe D, Sherwood D, Turner P, Walker T, Mistlin A, Phillip R, Nicol AM, Bennett AN, Bahadur S. The Stanford Hall consensus statement for post-COVID-19 rehabilitation. Br. J. Sports Med. 2020;54(16):949–959. doi: 10.1136/bjsports-2020-102596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Carubbi F, Salvati L, Alunno A, Maggi F, Borghi E, Mariani R, Mai F, Paoloni M, Ferri C, Desideri G, Cicogna S, Grassi D. Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units. Sci. Rep. 2021;11(1):4863. doi: 10.1038/s41598-021-83831-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Frater JL, Zini G, d’Onofrio G, Rogers HJ. COVID-19 and the clinical hematology laboratory. Int. J. Lab. Hematol. 2020;42(Suppl, 1):11-18. 10.1111/ijlh.13229 [DOI] [PMC free article] [PubMed]
- 8.Gautret P, Million M, Jarrot PA, Camoin-Jau L, Colson P, Fenollar F, Leone M, La Scola B, Devaux C, Gaubert JY, Mege JL, Vitte J, Melenotte C, Rolain JM, Parola P, Lagier JC, Brouqui P, Raoult D. Natural history of COVID-19 and therapeutic options. Expert Rev. Clin. Immunol. 2020;16(12):1159–1184. doi: 10.1080/1744666X.2021.1847640. [DOI] [PubMed] [Google Scholar]
- 9.Hao F, Tan W, Jiang L, Zhang L, Zhao X, Zou Y, Hu Y, Luo X, Jiang X, McIntyre RS, Tran B, Sun J, Zhang Z, Ho R, Ho C, Tam W. Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry. Brain Behav. Immun. 2020;87:100–106. doi: 10.1016/j.bbi.2020.04.069. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Li H, Zhao X, Wang Y, Lou X, Chen S, Deng H, Shi L, Xie J, Tang D, Zhao J, Bouchard LS, Xia L, Zhou X. Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI. Sci. Adv. 2021;7(1):eabc8180. 10.1126/sciadv.abc8180 [DOI] [PMC free article] [PubMed]
- 11.Pérez-Gil J. Structure of pulmonary surfactant membranes and films: The role of proteins and lipid-protein interactions. Biochim. Biophys. Acta. 2008;1778(7-8):1676–1695. doi: 10.1016/j.bbamem.2008.05.003. [DOI] [PubMed] [Google Scholar]
- 12.Rybakova MG, Karev VE, Kuznetsova IA. Anatomical pathology of novel coronavirus (COVID-19) infection. First impressions. Arkh. Patol. 2020;82(5):5–15. doi: 10.17116/patol2020820515. [DOI] [PubMed] [Google Scholar]
- 13.Ufuk F, Savaş R. Chest CT features of the novel coronavirus disease (COVID-19) Turk. J. Med. Sci. 2020;50(4):664–678. doi: 10.3906/sag-2004-331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Vaes AW, Machado FVC, Meys R, Delbressine JM, Goertz YMJ, Van Herck M, Houben-Wilke S, Franssen FME, Vijlbrief H, Spies Y, Van ‘t Hul AJ, Burtin C, Janssen DJA, Spruit M.A. Care dependency in non-hospitalized patients with COVID-19. J. Clin. Med. 2020;9(9):2946. 10.3390/jcm9092946 [DOI] [PMC free article] [PubMed]
- 15.Zhao YM, Shang YM, Song WB, Li QQ, Xie H, Xu QF, Jia JL, Li LM, Mao HL, Zhou XM, Luo H, Gao YF, Xu AG. Followup study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine. 2020;25:100463. doi: 10.1016/j.eclinm.2020.100463. [DOI] [PMC free article] [PubMed] [Google Scholar]