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. 2022 Jan 1;27(1):264. doi: 10.3390/molecules27010264

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Microscopic fields (40×) of the in vitro uptake and internalization in the N30 cells (FAP-positive) of (b) Lu₂O₃-iFAP and (e) Lu₂O₃ nanoparticles, detailing (a,d) the Hoechst-stained nucleus, and the merged images of nuclear and N30 cells treated with (c) Lu₂O₃-iFAP or (f) Lu₂O₃ (control). Observe the qualitative difference regarding the number of lutetium oxide nanoparticles (bright spots) between the Lu₂O₃-iFAP (b) and nanoparticles without iFAP (e) in the membrane and cytoplasm of N30 cells.