Figure 2.

Schematic representation of some of the important miRNAs associated with osteoporosis progression. These miRNAs have been described as relevant regulators of targets associated with bone mineralization, osteogenic differentiation, and osteoclast differentiation. When bone resorption increases (a) and osteogenesis is restrained (b), osteocyte lacunae decrease (c), which subsequently drives to the loss of bone mineral density and the occurrence of osteoporosis.