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. 2021 Dec 30;27(1):209. doi: 10.3390/molecules27010209

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

Nisa Najibah Mahleyuddin 1,, Said Moshawih 1,, Long Chiau Ming 1, Hanis Hanum Zulkifly 2, Nurolaini Kifli 1, Mei Jun Loy 3, Md Moklesur Rahman Sarker 4, Yaser Mohammed Al-Worafi 5,6, Bey Hing Goh 7,8, Shobna Thuraisingam 9, Hui Poh Goh 1,*
Editor: Maria João Matos
PMCID: PMC8747064  PMID: 35011441

Abstract

Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analgesic effects. The cardiovascular benefits of C. sativum have not been summarized before, hence this review aims to further evaluate and discuss its effectiveness in cardiovascular diseases, according to the recent literature. An electronic search for literature was carried out using the following databases: PubMed, Scopus, Google Scholar, preprint platforms, and the Cochrane Database of Systematic Reviews. Articles were gathered from the inception of the database until August 2021. Moreover, the traditional uses and phytochemistry of coriander were surveyed in the original resources and summarized. As a result, most of the studies that cover cardiovascular benefits and fulfilled the eligibility criteria were in vivo, while only a few were in vitro and clinical studies. In conclusion, C. sativum can be deemed a functional food due to its wide range of cardiovascular benefits such as antihypertensive, anti-atherogenic, antiarrhythmic, hypolipidemic as well as cardioprotective effects.

Keywords: Coriandrum sativum, cardiovascular, coriander, antihypertensive, hypolipidemic, cardioprotective, functional food, ethnopharmacology

1. Introduction

Coriandrum sativum Linn. (C. sativum) or coriander, is recognized for its wide range of uses in culinary as well as traditional medicine in a variety of conditions [1]. Different chemical compounds have been identified in each part of the plant including roots, leaves, fruits, and seeds, which account for its broad spectrum of uses [2]. To name a few, such compounds include gallic acid, thymol, and bornyl acetate, which are expected to exert anticancer, anti-inflammatory, and autonomic relaxation induction effects, respectively [3,4,5]. Linalool, a terpene alcohol found in coriander, has been reported to be the main constituent that is responsible for some therapeutic values of coriander as it possesses neuroprotective, anxiolytic, anticonvulsant, and analgesic effects [6,7,8,9].

It is believed that every part of the plant possesses different nutritional and medicinal values; thus, it was traditionally consumed in diverse areas. Notably, coriander was used in India for relieving gastrointestinal discomfort, respiratory, and urinary complaints; additionally, in some areas of Pakistan, the whole plant of coriander has folk medicinal uses to treat flatulence, dysentery, diarrhea, and vomiting [10,11]. On the other hand, with its distinctive scent and flavor, coriander is often added to food in the culinary industry as a seasoning and a preservative agent; it can be used in the form of leaves and seeds, ground, or as a whole [12]. Furthermore, the powdered fruit of C. sativum has been used as a flavoring agent to mask the taste of some foods such as fish, meat, and baking recipes [13].

According to the World Health Organization [14] (WHO, 2019), the major cause of mortality worldwide is cardiovascular diseases (CVDs). CVDs are a group of heart and blood vessel disorders including coronary and peripheral artery diseases, rheumatic, cerebrovascular, and congenital heart disease, in addition to deep vein thrombosis and pulmonary embolism [15]. Despite possessing various health benefits which have been reported in many research and review papers [16,17,18], the cardioprotective effects of coriander have never been summarized in terms of the anti-atherogenic, antihypertensive, antiarrhythmic, and hypolipidemic effects [19]. Phytochemicals present in C. sativum, such as flavonoids, phenolic acids, phytosterols, and terpenes, have significant potential in cardiovascular health and have demonstrated an angiotensin-converting enzyme (ACE)-inhibiting potency, cardioprotective, antihyperlipidemic, and cardiometabolic disorder-inhibiting properties [20,21,22,23]. Therefore, the phytochemical constituents of C. sativum were reviewed and summarized in light of their presence in their respective extracts and connected to the biological activities shown. Moreover, this review also aims to further evaluate, summarize, and discuss the cardiovascular effects of coriander extracts in all contexts of in vitro, in vivo, and clinical studies that were performed on this herb.

1.1. Botanical Description and Taxonomy

C. sativum belongs to the Apiaceae (Umbelliferae) family, which is herbaceous and grows annually, with a height of 20–70 cm (Table 1). C. sativum is known as “coriander” or “Chinese parsley” in English; “cilantro” in Spanish; “kusthumbari” or “dhanya” in Sanskrit; “dhane” in Bengali; “pak chee” in Thailand; and “Yánsuī”, “Yán qiàn”, “Hú suī”, or “Xiāngcài” in Chinese [1,2,24]. It is thought to have originated in the regions of the Middle East and the Mediterranean, where its growth may have broadened to China, Europe, India, Africa, and Asia; nevertheless, several authors have considered coriander as a weed in cereals, and its origin is still not clear [25]. The leaves are green with a variable lanceolate shape and glabrous surfaces, while the flowers are white or pink in umbels with asymmetrical shapes (Figure 1 and Figure 2) [2,18]. Meanwhile, the seeds are dry schizocarps with two mericarps with oval-shaped globules. Furthermore, the stems of C. sativum are pale green with hollow branches and a glabrous surface [24].

Table 1.

The taxonomical classification of C. sativum is as follows.

Scientific Name: Coriandrum sativum
Common names: Coriander, Chinese Parsley, cilantro, kusthumbari, dhanya, dhane, pak chee, yuan sui, hu sui
Kingdom: Plantae
Subkingdom: Tracheobionta
Superdivision: Spermatophyta
Division: Magnoliophyta
Class: Magnoliopsida
Subclass: Rosidae
Order: Apiales
Family: Apiaceae/Umbelliferae
Genus: Coriandrum L.
Species: Coriandrum sativum L.

Figure 1.

Figure 1

(A) C. sativum flowers (by Andrey Zharkikh). (B) C. sativum half and whole seeds (by ZoyaChubby). From North Carolina Extension Gardner: Plant toolbox. (https://plants.ces.ncsu.edu/plants/coriandrum-sativum/, accessed on 20 December 2021).

Figure 2.

Figure 2

The leaves of Coriandrum sativum (by Forest and Kim Starr). From North Carolina Extension Gardner: Plant toolbox. (https://plants.ces.ncsu.edu/plants/coriandrum-sativum/, accessed on 20 December 2021).

1.2. Ethnomedicinal Uses

C. sativum was used as one of the earliest spices by humans. Traditionally, C. sativum seeds were consumed to relieve pain, rheumatoid arthritis, and inflammation [26], whereas the decoction of coriander was believed to treat mouth ulcers and eye redness [27]. The seeds have been prescribed to relieve gastrointestinal disorders such as flatulence, diarrhea, indigestion, and nausea [28]. Coriander is believed to exert these actions by stimulating the liver to increase the secretion of bile and other digestive enzymes which escalate the action of the digestive system, hence shortening the time of food passage through the gastrointestinal tract [29]. In countries such as Saudi Arabia, Jordan, and Morocco, coriander was also known to lower blood glucose levels [30,31,32], have antimicrobial properties against food-borne pathogens, such as Salmonella, in addition to aphrodisiac and analgesic power [33]. Furthermore, coriander has been used traditionally in Turkey and India to relieve indigestion [34]; increase water excretion; and prevent seizures, anxiety, and sleeplessness [35,36]. Moreover, it has been documented of C. sativum in Morocco being used traditionally in the treatment of diabetes, indigestion, flatulence, insomnia, renal disorders, loss of appetite, and as a diuretic [37]. Detailed traditional uses of C. sativum are presented in Table 2.

Table 2.

Traditional uses of C. sativum in different countries.

Traditional Uses Area Plant Parts Used Reference
Rheumatoid arthritis, inflammation, and joint pain India Seeds/seeds aqueous extract [26,38,39]
For measles, diabetes, aerophagy, gastroenteritis China The whole plant parts [40]
Antiviral and neuro-energizer Pakistani herbal drugs (Intellan) Aerial parts of the plant
Some liver diseases - Aqueous extract of the roasted seeds
Carminative, diuretic, dyspeptic complaints, loss of appetite, convulsion, insomnia, and anxiety and in medical purposes Iranian traditional medicine Powdered seeds or dry extract [38]
Diaphoretic, diuretic, carminative, and stimulant activity Iranian traditional medicine The whole plant parts [37,41]
Diuretic and for some renal diseases Morocco Oral administration of plant parts [42]
Mouth ulcer and eye redness - leaves decoction [27]
Grounded as an
ingredient of curry powder and gingerbread, also a component of liquesces and spirits. Aromatic ingredient of tobacco and perfumes.
In Unani medicine to quench thirst and for melancholia.
India Seeds and aqueous infusion of leaves [39]
Stimulant and carminative; stomachic, antibilious, digestive stimulant India Leaves [29]
Lower blood glucose levels Saudi Arabia, Jordan, Morocco Fruits, decoction of leaves and seeds [30,31,32]
Aphrodisiac, analgesic, antimicrobial properties - The volatile oil [33]
Appetizer, Digestive, Carminative Turkey Infusion of the seeds [34]
For anxiety, sedative and muscle relaxant effect - The aqueous extract [35,36]
Treats Influenza, bad breath, unpleasant odor from genitalia Traditional Chinese Medicine Seeds [43]
Against worm and to treat rheumatism The European pharmacopeia Fruits
Stimulates gastric secretion, treats gastric ulcers and mouth infections Asian region Essential oils

1.3. Phytochemistry

Recent studies revealed that different kinds of alkaloids, essential oils, fatty acids, flavonoids, phenolics, reducing sugars, sterols, tannins, and terpenoids were extracted from C. sativum [16,44]. In particular, the leaves were reported to have an abundant concentration of folates, ascorbic acid, gallic acid, caffeic acid, ferulic acid, and chlorogenic acid. Additionally, the investigation of the water-soluble components of C. sativum seeds showed the presence of 33 compounds, including monoterpenoid, monoterpenoid glycosides and glucosides, and aromatic compound glycosides such as norcarotenoid glucoside [45]. In the vegetative part of the C. sativum, different phenolics and flavonoids were detected in significantly high concentrations, such as quercetin diverse glycosides (405.36–3296.16 mg/kg), kaempferol 3-O-rutinoside (320.86 mg/kg), in addition to ferulic acid glucoside and p-coumaroylquinic acid [46]. Another study of the polyphenolic contents of coriander grass showed that a 40% ethanol extract contains many flavonoids (0.13% to 10.71%), coumarins (1.4% to 6.83%), and phenolcarboxylic acids (7.24% to 13.51%) [47]. Anthocyanin was also characterized in coriander leaves, and the concentration was found to be influenced by salicylic acid, nitrogen, phosphorus, potassium, and zinc fertilizers [48]. Figure 3 and Table 3 present the different phytochemical structure classes of C. sativum.

Figure 3.

Figure 3

Phytochemical molecular structures extracted from C. sativum, such as terpenes, phenolic acids, flavonoids, fatty acids, and phytosterols.

Table 3.

Main phytochemical constituents of C. sativum classified according to their chemical class, including the plant part that was extracted and the extraction method.

Phytochemical Components Chemical Class Plant Part Extraction Solvent/Method Reference
Ferulic acid, Gallic acid, and Caffeic acid Phenolic acids Above-ground parts Ether, ethyl acetate, butanol, and 2-ethyl acetate extracts [47]
Salicylic acid Benzoic acid derivative
Esculetin, Esculin, Scopoletin
4-Hydroxycoumarin, Umbelliferone, and Dicoumarin
Coumarins
Hyperoside, rutin, hesperidin, vicenin, diosmin, luteolin, apigenin, orientine, dihydroquercetin, catechin, and arbutin Flavonoids
β-carotene and total carotenoids Carotenoids Leaves at mature and young plant stage, fresh and dry seeds Ice-cold acetone was then partitioned against petroleum ether. [69]
α-, β-, γ- δ- tocopherols, and α-, γ-tocotrienols Tocols Whole fruit, pericarp, and seeds Extracted with n-hexane [70]
Petroselinic acid, linoleic acid, palmitic acid, and oleic acid Fatty acids Boiled in water, then grounded using a mixture of chloroform/methanol/hexane and finally separated by thin-layer chromatography
Stigmasterol, β-sitosterol, δ-stigmasterol Sterols Seed and pericarp of coriander fruit Extracted with n-hexane in a Soxhlet apparatus [71]
Linalool, camphor, and geraniol Essential oils Hydrodistillation followed by extraction with 2-methylbutane

These constituents of C. sativum were extracted by different methods, including solvent extraction such as n-hexane, water, and methanol, in addition to supercritical gases, microwave-assisted extraction, sonication, and hydrodistillation [20,49,50,51,52,53,54]. Essential oils (EOs) and fatty oils were the most significant components in the fruit, with a content of 0.03–2.6% and 9.9–27.7%, respectively [55]. Different EO chemotypes were detected in coriander seeds, including ketones, aliphatic aldehydes, aliphatic hydrocarbon, aliphatic alcohols, esters, monoterpene hydrocarbons, monoterpene oxides, monoterpene alcohols, monoterpene esters, and sesquiterpenes, with linalool as the main monoterpene alcohol extracted in high quantities [56]. The highest percentage of EO that has been yielded from coriander seeds was cultivated in Tunisia with a linalool content of 87.54% [57], while 73.1%, 40.9–79.9%, 37.65%, and 69.60% of linalool was extracted from C. sativum from Algeria, Iran, Bangladesh, and Pakistan, respectively [58,59,60].

EOs are obtainable by extracting different parts of the plant using hydrodistillation extraction [10], subcritical water, Soxhlet apparatus [61], solvent extraction, steam distillation, and supercritical CO2 methods [62]. However, the EO content is variable among different parts of the plant, which could be due to the different origins of cultivated varieties, climate and geographical conditions [10,63], the area and season of cultivation, the degree of plant maturation, and genotypes of the species. In particular, 2-dodecenal was found as the main volatile EO in the root and stalk, while 1-ethenyl-cyclododecanol was the highest volatile component in the leaves of C. sativum [64]. Furthermore, different percentages, components, and immunotoxicity were identified in oils extracted from the leaves than the stems’ EO extracts of the Korean C. sativum [65]. In addition, the essential oil yields and efficiencies of commercial coriander fruits from different countries were extracted and found to be different according to the geographical area [66]. The relationship between some environmental conditions in Argentina and the essential oil composition of two coriander landraces (European and Argentinean) has been studied [67]. It has also been found that genotypic and phenotypic variations contributed to the variety of essential oils’ concentrations, in addition to the interaction from other environmental conditions, such as fertilizers, weediness, and soil degradation. Likewise, the phenolic contents of the two C. sativum varieties, vulgare and microcarpum, were found to be similar but with different concentrations of the main phenolic compounds, namely quercetin-3-b-d glucoside and quercetin-3-O-glucuronide [68]. On top of that, the average EO yields for vulgare fruits (0.1% to 0.5%) are lower than that of the microcarpum (0.8–2.1%) [16]. Details of the total phytochemical constituents of C. sativum are presented in Table 3.

Different studies involved the characterization of C. sativum phytochemicals in the extracts that were employed in bioactivity determination. However, very few studies involved the bioactivity-guided isolation of a specific compound that is responsible for that pharmacological action. Quercetin-rich aqueous ethanolic extract was found beneficial in α-amylase and α-glucosidase inhibition and thus has a potential antidiabetic effect [72]. The extract also contained some other flavonoid compounds such as vanillic acid, caffeic acid, and p-coumaric acid, whereas the total phenolic content was 2.68 ± 0.07 mg GAE/g DW. Lipase inhibition activity for 1 mg/mL of aqueous ethanol was 55.76 ± 1.40% which indicates a significantly strong anti-obesity property. In the same study, the angiotensin-converting enzyme was inhibited by coriander extracts to 70.66 ± 2.34% which shows that the polyphenolic-rich extract can be beneficial for hypertension in vitro. Moreover, the diabetic nephropathy prevention and hypolipidemic activities were illustrated in the petroleum ether extract of C. sativum seeds that are rich in linalool, ascorbyl palmitate, and petroselinic acid [73]. The saturation of hexokinase enzymes due to diabetes leads to the formation of advanced glycation end products (AGEs), which when interacting with their receptors cause vascular aging and renal damage [74]. From the above-mentioned study, it was found that linalool in addition to other terpenes and fatty acids has the potential to bind with the RAGE receptor and subsequently block AGEs’ damaging action. In a different study, the Eos’ major components of C. sativum were linalool, γ-terpinene, and α-pinene with prominent activities against diabetes, microbial infections, and acetylcholinesterase enzyme [75]. Other activities such as hypotensive [20] and neuroprotective ones [76] were detected in flavonoids- and isocoumarin glycosides-containing fractions of C. sativum, respectively. The isocoumarin glycosides cilantroside A and B, in addition to the phenolic glycosides daphnin and benzyl-O-β-d-glucoside, have been found to stimulate nerve growth factor as the main neurotrophic factor which is related to nerve growth, maintenance, and neuronal survival. Moreover, the aglycones of the isocoumarins showed anti-inflammatory effects in addition to more significant neurotrophic properties than their glycosides. Figure 4 indicates the details on studies performed on C. sativum with the characterization or isolation of the phytochemicals in the respective extract/fraction.

Figure 4.

Figure 4

The role of C. sativum phytochemicals in some of its biological activities from different studies ① Suttisansanee, Thiyajai, Chalermchaiwat, Wongwathanarat, Pruesapan, Charoenkiatkul and Temviriyanukul [72], ② Kajal and Singh [73], ③ Hajlaoui, Arraouadi, Noumi, Aouadi, Adnan, Khan, Kadri and Snoussi [75], ④ Hajlaoui, Arraouadi, Noumi, Aouadi, Adnan, Khan, Kadri and Snoussi [75], ⑤ Cha, Yoon, Kim, Kim and Lee [76], and ⑥ Ramadan, et al. [77].

2. Results

From previous studies, C. sativum has demonstrated its cardioprotective efficacies (refer to Graphical Abstract). These include its effect as an antioxidant, antihypertensive, anti-atherogenic, antiarrhythmic, as well as the improvement of other factors that may lead to CVDs, such as increased lipid profile and cardiac biomarkers or enzymes. From the PRISMA flow diagram, Figure 3 demonstrates the search strategy that has been used and its results; a total of 3008 studies were screened and 13 were excluded from this review as duplicate records before the screening. A total of 2977 studies were further excluded for not meeting the determined inclusion criteria, thus leaving only 18 studies to be retrieved and included in this review. Twelve in vivo, two in vitro, and two clinical studies in addition to two mixed in vivo and in vitro studies were retrieved. The results of the studies included in this review, plant parts extracted, extraction method, dose employed, phytochemicals characterized, and isolation method are summarized in Table 4.

Table 4.

Cardiovascular potential of C. sativum from previous studies with details about the plant part used, extraction method, dosage em-ployed, phaytochemicals characterized, and isolation method.

Plant Part Extraction Method Dosage Employed Phytochemicals Characterized Isolation Method Experimental Subject Cardiovascular Effects (Outcome) Reference
Leaves and stem Ethanol extraction 200 mg/kg Phenolics, flavonoids Evaporation Wistar albino rats Antioxidant, Hypolipidemic
Normoglycemic
Ananthan, et al. [78]
Seeds Methanol extraction 100 mg/kg,
200 mg/kg,
300 mg/kg
N/D Reduced pressure Adult male Wistar rats Decrease cardiac damage that causes myocardial infarction Patel, Desai, Gandhi, Devkar and Ramachandran [49]
Seeds Soxhlet extraction 250 mg/kg N/D Reduced pressure Male albino rabbits Hypolipidemic Sharma, et al. [79]
Market-procured coriander powder suspended in water - 1 g/kg N/D - Male Wistar rats Hypolipidemic Lal, et al. [80]
Seed powder - 2 g per day N/D - Human individuals Lower elevated blood pressure, Hypocholesterolemic Zeb, et al. [81]
Market-procured seeds, powdered - 5 g per day N/D - Type 2 diabetic patients Hypolipidemic, antioxidant Rajeshwari, et al. [82]
Seeds Aqueous extraction 200 mg/kg N/D - Meriones shawi rats Hypolipidemic
Normo-glycemic
Cardioprotective
Aissaoui, et al. [83]
Seeds Hydrodistillation IC50: 34.8 ± 2.3 μg/mL Linalool Hydrodistillation In vitro study Antihypertensive, Antioxidant Chaudhary, et al. [84]
Seeds Maceration in methanol 183 mg/kg N/D - Rats Cardioprotective Afsheen, et al. [85]
Seeds Homogenized seeds 10% of diet N/D - Sprague-Dawley rats Hypolipidemic Dhanapakiam, et al. [86]
Seeds Aqueous extraction 1 g/kg N/D - Wistar albino rats Cardioprotective,
Hypolipidemic, Antioxidant,
Improved left ventricle functions
Dhyani, et al. [87]
Leaves Soxhlet extraction with multiple solvents IC50: 28.91 ± 13.42 μg/mL Pinocembrin, Apigenin, pseudobaptigenin, galangin-5-methyl ether, quercetin, baicalein, kaempferol, pinobanksin-glycosides, rutin, isorhamnetin, daidzein, luteolin, pectolinarigenin LC-ESI-MS/MS In vitro study Antihypertensive Hussain, Jahan, Rahman, Sultana and Jamil [20]
Seeds Solvent extraction Addition of 100 g to diet Stigmasterol, Lanosterol, β-Sitosterol, D5Avenasterol, Sitostanol, D7stigmastenol, D7
Avenasterol, Tocopherols
Gas-liquid chromatography Male albino rats Hypocholesterolemic effect Ramadan, Amer and Awad [77]
Seeds Homogenized seeds 10% of diet N/D - Female albino rats Hypolipidemic Chithra and Leelamma [88]
Seeds Water extraction 300 mg/kg N/D - Male albino rats Antiarrhythmic Rehman, Jahan, Khalil ul, Khan and Zafar [51]
Seeds Maceration with Aqueous/Methanol 200 mg/kg N/D - In vitro and in vivo study on
Sprague-Dawley rats
Antioxidant, Hypocholesterolemic Anti-atherogenic Patel, et al. [89]
Fruit Maceration with Aqueous/Methanol 1–30 mg/mL as hypotensive 1–10 mg/kg as diuretic N/D Organic fractionation of the crude extract In vivo and in vitro study Anti-hypertensive, Diuretic Jabeen, Bashir, Lyoussi and Gilani [50]
Leaves Maceration with Methanol 100 mg/kg N/D - Rabbits Hypolipidemic Kousar, et al. [90]

3. Discussion

3.1. Hypolipidemic Activity

Crude C. sativum extract has been shown to lower the levels of triacylglycerol (TCA) and total cholesterol (TC), indicating its potential in decreasing blood lipid profile in rats [77,79,80,82,83,86,87,88,90]. Bioactive sterols, which contain mono- and polyunsaturated fatty acids, such as stigmasterols and sitosterols, and polar lipids, are present in coriander extract in high amounts [77]. In addition, the presence of antioxidants, such as tocopherols and phenolics, protects the unsaturated fatty acids from peroxidation [91]. Saturated fatty acids likely elevate the low-density lipoprotein cholesterol (LDL-C) levels, while unsaturated fatty acids, including monounsaturated and polyunsaturated fatty acids (PUFA), reduce LDL-C levels [92]. The higher intake of PUFA-containing oils in food helps in incorporating more unsaturated fatty acids in plasma lipoproteins, which improves their particle size and subclass distribution more than when it involves a higher content of cholesterol particles due to the fact that the fatty esters such as PUFA are bigger in size [93]. Additionally, cholesterol as a rigid fat will be incorporated more as a cell membrane component instead of circulating in blood since the fluidity of unsaturated acids in membranes must be balanced with rigid fats [94]. Moreover, phytochemical components such as flavonoids and polyphenols can also be responsible for the hypolipidemic property of coriander, whereby the flavonoids are responsible for reducing FAS proteins which are involved in energy metabolism. The inhibition of the expression of FAS in the liver by stimulating AMPK activity in hepatocyte cells via the liver kinase B1 pathway may thereby reduce fatty acid synthesis in the liver and subsequently, fat accumulation [95].

Another potential hypolipidemic mechanism for coriander seeds proposed by Chithra and Leelamma [88] may involve a significant increase in the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA) activity which is a key enzyme in the biosynthesis of cholesterol. Since liver cholesterol was significantly reduced in rats administered coriander, it was most likely because the rate of its degradation to bile acids was more than its rate of synthesis. Other than that, Sharma, Sharma, Jasuja and Joshi [79] found an increase in the excretion of cholesterol and phospholipids in the fecal matter of rabbits that were administered C. sativum seed extract. Generally, plant sterols and stanols reduce intestinal absorption of cholesterol, increase neutral fecal sterol excretion, and prevent liver cholesterol accumulation; however, they did not cause liver X receptor target gene induction, such as Abcg5, Abcg8, or Npc1l1. Thus, phytosterol-induced cholesterol absorption reduction was independent of Abcg5/8 Transporter [96].

In contrast, the reduction of TC levels was attributed to the amount of fibers added to the experimental diet of hypertriglyceridemic rats [88,97], which further increases plasma lecithin cholesterol acyltransferase (LCAT) activity, amplifies the synthesis of hepatic bile acids, thus increasing the cholesterol degradation in the fecal excretion of bile acids and cholesterol, and decreases the LDL liver production. Coriander seed oil is rich in sterols, predominantly stigmasterol and β-sitosterol, which work preemptively on inhibiting the absorption of dietary cholesterol [88,98]. The slight difference between stigmasterol and cholesterol structures allows the former to be incorporated in intestinal micelle to displace cholesterol and subsequently reduces the latter absorption. Furthermore, phytosterols, especially stigmasterol, increase the enzyme activity of HMG-CoA reductase, which suppresses cholesterol absorption and enhances hepatic bile acids synthesis and thus, increases the degradation of cholesterol [99].

3.2. Antioxidant and Anti-Atherogenic Properties

Antioxidants play an important role in the promotion of cardiovascular health since oxidative stress that inflicts the myocardium can be associated with the incidence of atherosclerosis, which increases the risk of coronary artery disease [100,101]. C. sativum has been demonstrated in many studies to possess a pronounced antioxidant activity, and this is mainly due to the activity of polyphenols, vitamins, and sterol constituents of coriander [78,89,90].

In particular, the antioxidant mechanism that is correlated with the ability of C. sativum phytochemicals is to inhibit scavenger receptor (SRB1) expression, which in turn decreases the number of foam cell formations and subsequently reduces the atherogenic plaques [79,89]. Furthermore, the atherosclerosis mechanism involves the accumulation of LDL-C within the walls of arteries, which then develop into a cholesterol plaque. Described as an inflammatory disease, atherosclerosis involves the oxidation processes by reactive oxygen species and lipoxygenases, along with enzymatic changes that occur to the entrapped LDL-C and extracellular matrix (ECM). Those changes increase the generation of adhesion molecules and chemokines from endothelial cells that boost the adhesiveness of monocytes on the cell wall, which also facilitates the infiltration of inflammatory cells into the subendothelial spaces [102,103]. This results in the recruitment of macrophages to scavenge this oxidized LDL (Ox-LDL) via scavenger receptor (SRB1), which is subsequently converted into lipid-laden foam cells [104]. Eventually, these cells undergo apoptotic death in which the apoptotic bodies mimic a fatty streak [105]. Furthermore, this increases the recruitment of macrophages having a similar fate, whereby the buildup of the by-products promotes atherosclerosis [105]. Therefore, coriander extract lowers the development of Ox-LDL in a dose-dependent manner as it has demonstrated the reduction in the number of foam cells due to its potential to prevent the expression of SRB1 [79,89].

Another potential antioxidant mechanism is associated with the high levels of polyphenol in the leaf extract of C. sativum [106,107], which acts as a free radical scavenger, thus preventing oxidative damage to the myocardial tissues [89]. Free radicals are highly reactive; for instance, hydroxyl radicals can cause damage to membrane phospholipids, DNA, and proteins, in which the former would result in the formation of peroxyl radicals [77]. Thus, when there are insufficient natural antioxidant components in the body, such as superoxide dismutase (SOD) enzyme and glutathione peroxidase (GSH-px), an oxidative chain reaction may occur [78], resulting in tissue damage [108]. However, it has been reported that this strong antioxidant potential of coriander may also be due to the synergistic effect of the combination of different antioxidant compounds, such as tocopherols and sterols [77].

Plants with green leaves such as coriander produce volatile oils, usually composed of (E)-2-Alkenals, emitted when wounds and stress are applied to them as a defense mechanism. N-pentane extract of C. sativum accounts for 70% of the components of its essential oil to this kind of green leaf volatiles [109]. It has been suggested that those alkenals attach to Keap1 proteins through electrophilic modification by the α, β-unsaturated aldehyde group, resulting in Nrf2 activation. This activation leads to detoxification and ROS neutralization in different in vivo and in vitro assays [110]. Furthermore, umbelliferone is a coumarin derivative that was extracted from C. sativum using methanol [111] and is also found to increase the expression of Nrf2 in addition to CREB, SIRT1, FOXO-3, PPAR-γ genes, and proteins. SIRT1 upregulation plays a key role in regulating oxidative defense mechanisms and DNA repair [112] and can be considered one of the pathways in which coriander illustrates its antioxidant and anti-atherogenic effects.

Furthermore, a study by Dhyani, Parveen, Siddiqi, Hussain and Fahim [87] demonstrated the ability of C. sativum seed extract to improve the cardiac hemodynamic parameters, namely systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and mean arterial pressure (MAP) in the experimental rats. The reflective response in the case of myocardial ischemic injury is illustrated by a decline in the MAP and an increase in the HR and cardiac contractility, whereby the latter happens due to the activation of baroreceptors, eventually leading to vasoconstriction and hence enhancing the imbalance between the oxygen supply and demand in the cardiac tissues [87]. The coriander extract is expected, as illustrated in the above-mentioned studies, to improve these parameters, and ultimately, the event of MI can be prevented. A cardioprotective effect was also demonstrated for the polyphenol-rich extract of C. sativum due to its antioxidant potential that is associated with preventing myocardial infarction due to myofibrillar injury after the isoproterenol-induction of cardiac damage in male Wister rats [49]. The elevation of the reactive oxygen species is associated with myocardial damage, causing necrosis, apoptosis, or autophagy due to the swelling of mitochondria, which is attributed to the calcium being diverted to it after disruption in its handling between the sarcoplasmic reticulum and myofilament [113].

In addition to the mechanisms above, the histology of the aorta was also studied to determine the effect of C. sativum extract on cholesterol deposition in rabbits, showing almost normal histology whereby the aorta and the size of the lumen were restored to almost the normal state, thus proving the anti-atherogenic potential of coriander. In contrast to that, the histological observation of the aorta of cholesterol-fed animals without the extract treatment exhibited atheromatous plaque as compared to the normal-fed group. The lipids deposited in the atherosclerotic lesions are mostly derived from LDL, which can be oxidized by pro-oxidants, resulting in plaques characterized by lipid-laden foam cells within the innermost and middle layers of the aorta [79]. The atherogenic index serves as a crucial prognostic indicator for CVDs such as atherosclerosis [114], which represents the ratio between cholesterol and high-density lipoprotein (HDL) [115]. Increased risk of myocardial infarction is denoted by the atherogenic index of more than five [116]. Moreover, a significant decrease in this ratio by C. sativum extract has been reported in a previous study by Sharma, Sharma, Jasuja and Joshi [79] and Aissaoui, Zizi, Israili and Lyoussi [83], indicating another potential of coriander as a functional food to decrease the risk of CVDs.

3.3. Antihypertensive Potential

Another potential cardioprotective effect of C. sativum is its antihypertensive property [20,51]. This property is attributed to the flavonoid-rich leaves of C. sativum, particularly involving the angiotensin-converting enzyme (ACE) inhibition mechanism that has been illustrated in vitro by Hussain, Jahan, Rahman, Sultana and Jamil [20], whereby its IC50 value was 28.91 μg/mL, which is comparable to other plants possessing the same property as the IC50 values of plant extracts that exhibit this enzyme inhibition ranges from 16–310 μg/mL [117,118,119]. Flavonoids that have been identified in coriander leaves include quercetin, rutin, apigenin, and luteolin [120,121,122], which have also been proven to show hypotensive effects individually and in crude extracts in diverse mechanisms [123,124,125,126]. The potential mechanism in the management of hypertension through the inhibition of ACE involves the control of the production of nitric oxide (NO) by the regulatory mechanism of the renin-angiotensin-aldosterone system (RAAS) with ACE inhibition as a fundamental regulator of blood pressure [20]. NO is an essential vasodilator in the regulation of blood pressure. ACE binds with the substrate in addition to the zinc ion in the complex, resulting in the polarization of the carbonyl group, thus promoting a nucleophilic attack, which contributes to an elevation in blood pressure [20]. Therefore, some flavonoids, as well as the free hydroxyl groups of flavonoids, inhibit ACE action by chelation with the zinc ion on the active site of ACE [127], which might be due to the formation of hydrogen bridges with amino acids nearby this active site [128,129,130]. Hence, this demonstrates the cardioprotective effect of coriander extract by the action of this class of polyphenols.

Furthermore, the investigation of the antihypertensive effect of the crude extract of C. sativum in anesthetized rats was shown to induce the relaxation of arterial contractions, thus lowering blood pressure [50]. It has been reported that such an effect occurs due to the combination of the cholinergic and calcium channel blocking effects of coriander bioactive compounds [131]. Additionally, the diuretic effect of C. sativum contributes to this antihypertensive activity by increasing the loss of electrolytes in the urine output [132]. Therefore, the findings from those studies potentiate the assumption of the instrumental use of coriander extract in hypertension as a functional food.

3.4. Antiarrhythmic Activity

Arrhythmia is one of the CVDs, which can be defined as irregular patterns of heart rate or rhythm that could be either tachycardia or bradycardia [133]. The antiarrhythmic activity of C. sativum seed extract has been evaluated in a study by Rehman, Jahan, Khalil ul, Khan and Zafar [51] that resulted in the reduction of pulse rate as well as the normalization of electrocardiogram (ECG) patterns and cardiac biomarker levels, which include lactate dehydrogenase (LDH), creatine kinase-MB fraction (CK-MB), aspartate transaminase (AST), and alanine transaminase (ALT). Rehman, Jahan, Khalil ul, Khan and Zafar [51] found that the anti-tachycardia efficiency of C. sativum was comparable with the beta-blocker drug propranolol, but less for the anti-bradycardia effect than that of atropine, whereby the presence of polyphenolic compounds may be responsible for this action. Polyphenols bind with beta-adrenergic receptors for the regulation of heart rate, as well as having a negative chronotropic effect which may slow down myocytes’ action potential, thus possibly deterring arrhythmias [107].

4. Materials and Methods

Electronic databases that were used for this review were PubMed, Scopus, Google Scholar, preprint platforms, and the Cochrane Database of Systematic Reviews. The articles were gathered from the inception of the database until August 2021. The strategies used for the electronic search are shown in Figure 5 (PRISMA Flow diagram).

Figure 5.

Figure 5

PRISMA Flow Diagram.

The terms used to conduct the search included: “Coriandrum sativum”, coriander, cilantro, cardiovascular, hypertensive, blood pressure, atherosclerosis, myocardial, cardiology, cardiac, heart, hyperlipidemia, cholesterol, health benefit, benefit, uses, clinical effect, clinical use, medicine, ethnomedicine, phytotherapy, and ethnobotany. These terms were used in combination with the Boolean operators “AND” and “OR”, and the search strategy can be found in Supplementary Table S1. The search terms for Preprint Platform were restricted to “Coriandrum sativum”, coriander, and cilantro to limit the search results for the topic of interest.

The eligibility of studies to be included in this review was assessed according to the following inclusion and exclusion criteria:

Inclusion criteria:

  1. Articles including research articles, guidelines, monographs, technical papers, conference proceedings;

  2. Studies that are reported in the English language only,

  3. Treatment of cardiovascular diseases;

  4. Human studies, in vivo animal model, and in vitro laboratory studies;

  5. There was no limitation imposed on the year of publication of the studies.

Exclusion criteria: Studies that assess other benefits of coriander that do not relate to cardiovascular health, reviews, letters, case studies, conference papers, opinions, reports, or editorial papers.

Screening of publications on studies relevant to coriander that examine its cardioprotective activity was conducted. Relevant literature was retrieved and reviewed in case they were related to the pharmacological properties and therapeutic actions of C. sativum.

5. Conclusions

Coriander has been widely used over the past centuries for both culinary and traditional purposes. Although linalool has been identified in C. sativum extract as the main component in the extracted oil, many flavonoids, phenolic acids, and phytosterols were found to be the major groups of phytochemicals that are expected to be accountable for the cardioprotective effects of coriander. In this review, the efficacy of coriander in CVDs has been discussed and evaluated according to the previous studies and reports, in which C. sativum is shown to exhibit hypolipidemic, antioxidant, antiatherogenic, antihypertensive, and antiarrhythmic properties in a dose-dependent manner. The included studies in this systematic review shed the light on the cardioprotective ability of coriander; however, more in vitro studies are needed to elucidate the mechanism of action of its extracts in cardiovascular diseases. Clinical trials are also warranted for fresh and extracted C. sativum to confirm the results presented in this review in an endeavor to consider it as a functional food and nutraceutical agent that can be consumed for therapeutic and nutritive purposes.

Supplementary Materials

The following supporting information can be downloaded at: Table S1: Table of search terms combination and strategy.

Author Contributions

Conceptualization, L.C.M. and H.P.G.; methodology, N.N.M. and Y.M.A.-W.; formal analysis, N.N.M. and S.M.; investigation, H.H.Z.; data curation, N.N.M. and N.K.; writing—original draft preparation, N.N.M. and M.J.L.; writing—review and editing, S.M., S.T. and M.M.R.S.; visualization, S.M. and H.P.G.; supervision, B.H.G., H.P.G. and L.C.M.; project administration, B.H.G., S.T. and H.P.G. All authors have read and agreed to the published version of the manuscript.

Funding

This research work did not receive any external funding.

Institutional Review Board Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

Footnotes

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

  • 1.Prachayasittikul V., Prachayasittikul S., Ruchirawat S., Prachayasittikul V. Coriander (Coriandrum sativum): A promising functional food toward the well-being. Food Res. Int. 2018;105:305–323. doi: 10.1016/j.foodres.2017.11.019. [DOI] [PubMed] [Google Scholar]
  • 2.Mandal S., Mandal M. Coriander (Coriandrum sativum L.) essential oil: Chemistry and biological activity. Asian Pac. J. Trop. Biomed. 2015;5:421–428. doi: 10.1016/j.apjtb.2015.04.001. [DOI] [Google Scholar]
  • 3.Riella K.R., Marinho R.R., Santos J.S., Pereira-Filho R.N., Cardoso J.C., Albuquerque-Junior R.L., Thomazzi S.M. Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents. J. Ethnopharmacol. 2012;143:656–663. doi: 10.1016/j.jep.2012.07.028. [DOI] [PubMed] [Google Scholar]
  • 4.Matsubara E., Fukagawa M., Okamoto T., Ohnuki K., Shimizu K., Kondo R. (−)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition. Biomed. Res. 2011;32:151–157. doi: 10.2220/biomedres.32.151. [DOI] [PubMed] [Google Scholar]
  • 5.Sun G., Zhang S., Xie Y., Zhang Z., Zhao W. Gallic acid as a selective anticancer agent that induces apoptosis in SMMC-7721 human hepatocellular carcinoma cells. Oncol. Lett. 2016;11:150–158. doi: 10.3892/ol.2015.3845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.de Lucena J.D., Gadelha-Filho C.V.J., da Costa R.O., de Araujo D.P., Lima F.A.V., Neves K.R.T., de Barros Viana G.S. L-linalool exerts a neuroprotective action on hemiparkinsonian rats. Naunyn. Schmiedebergs Arch. Pharm. 2020;393:1077–1088. doi: 10.1007/s00210-019-01793-1. [DOI] [PubMed] [Google Scholar]
  • 7.Souto-Maior F.N., de Carvalho F.L., de Morais L.C., Netto S.M., de Sousa D.P., de Almeida R.N. Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models. Pharm. Biochem. Behav. 2011;100:259–263. doi: 10.1016/j.pbb.2011.08.029. [DOI] [PubMed] [Google Scholar]
  • 8.Souto-Maior F.N., Fonseca D.V., Salgado P.R., Monte L.O., de Sousa D.P., de Almeida R.N. Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide. Pharm. Biol. 2017;55:63–67. doi: 10.1080/13880209.2016.1228682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Li X.J., Yang Y.J., Li Y.S., Zhang W.K., Tang H.B. alpha-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. J. Ethnopharmacol. 2016;179:22–26. doi: 10.1016/j.jep.2015.12.039. [DOI] [PubMed] [Google Scholar]
  • 10.Laribi B., Kouki K., M’Hamdi M., Bettaieb T. Coriander (Coriandrum sativum L.) and its bioactive constituents. Fitoterapia. 2015;103:9–26. doi: 10.1016/j.fitote.2015.03.012. [DOI] [PubMed] [Google Scholar]
  • 11.Khan S.W., Khatoon S. Ethnobotanical studies on some useful herbs of Haramosh and Bugrote valleys in Gilgit, northern areas of Pakistan. Pak. J. Bot. 2008;40:43. [Google Scholar]
  • 12.Singletary K. Coriander: Overview of potential health benefits. Nutr. Today. 2016;51:151–161. doi: 10.1097/NT.0000000000000159. [DOI] [Google Scholar]
  • 13.Mahendra P., Bisht S. Coriandrum sativum: A daily use spice with great medicinal effect. Pharmacogn. J. 2011;3:84–88. doi: 10.5530/pj.2011.21.16. [DOI] [Google Scholar]
  • 14.World Health Organization Cardiovascular Diseases. [(accessed on 25 September 2021)]. Available online: https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1.
  • 15.Rahman F.A., Abdullah S.S., Manan W., Tan L.T., Neoh C.F., Ming L.C., Chan K.G., Lee L.H., Goh B.H., Salmasi S., et al. Efficacy and Safety of Cyclosporine in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis. Front. Pharm. 2018;9:238. doi: 10.3389/fphar.2018.00238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Wei J.N., Liu Z.H., Zhao Y.P., Zhao L.L., Xue T.K., Lan Q.K. Phytochemical and bioactive profile of Coriandrum sativum L. Food Chem. 2019;286:260–267. doi: 10.1016/j.foodchem.2019.01.171. [DOI] [PubMed] [Google Scholar]
  • 17.Khazdair M.R., Anaeigoudari A., Hashemzehi M., Mohebbati R. Neuroprotective potency of some spice herbs, a literature review. J. Tradit. Complement. Med. 2019;9:98–105. doi: 10.1016/j.jtcme.2018.01.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Sahib N.G., Anwar F., Gilani A.H., Hamid A.A., Saari N., Alkharfy K.M. Coriander (Coriandrum sativum L.): A potential source of high-value components for functional foods and nutraceuticals—A review. Phytother. Res. 2013;27:1439–1456. doi: 10.1002/ptr.4897. [DOI] [PubMed] [Google Scholar]
  • 19.Chrysant S.G., Chrysant G.S. Herbs Used for the Treatment of Hypertension and their Mechanism of Action. Curr. Hypertens. Rep. 2017;19:77. doi: 10.1007/s11906-017-0775-5. [DOI] [PubMed] [Google Scholar]
  • 20.Hussain F., Jahan N., Rahman K.U., Sultana B., Jamil S. Identification of hypotensive biofunctional compounds of Coriandrum sativum and evaluation of their Angiotensin-Converting Enzyme (ACE) inhibition potential. Oxid. Med. Cell. Longev. 2018;2018:4643736. doi: 10.1155/2018/4643736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Agunloye O.M., Oboh G., Ademiluyi A.O., Ademosun A.O., Akindahunsi A.A., Oyagbemi A.A., Omobowale T.O., Ajibade T.O., Adedapo A.A. Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: Mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats. Biomed. Pharm. 2019;109:450–458. doi: 10.1016/j.biopha.2018.10.044. [DOI] [PubMed] [Google Scholar]
  • 22.Micallef M.A., Garg M.L. Beyond blood lipids: Phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia. J. Nutr. Biochem. 2009;20:927–939. doi: 10.1016/j.jnutbio.2009.06.009. [DOI] [PubMed] [Google Scholar]
  • 23.Oliveira J.R., Ribeiro G.H.M., Rezende L.F., Fraga-Silva R.A. Plant Terpenes on Treating Cardiovascular and Metabolic Disease: A Review. Protein Pept. Lett. 2021;28:750–760. doi: 10.2174/0929866528999210128210145. [DOI] [PubMed] [Google Scholar]
  • 24.Al-Snafi A.E. A review on chemical constituents and pharmacological activities of Coriandrum sativum. IOSR J. Pharm. 2016;6:17–42. doi: 10.9790/3013-067031742. [DOI] [Google Scholar]
  • 25.Diederichsen A. Coriander: Coriandrum sativum L. Volume 3 Bioversity International; Rome, Italy: 1996. [Google Scholar]
  • 26.Nair V., Singh S., Gupta Y.K. Anti-granuloma activity of Coriandrum sativum in experimental models. J. Ayurveda Integr. Med. 2013;4:13–18. doi: 10.4103/0975-9476.109544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Paniagua-Zambrana N.Y., Bussmann R.W., Romero C. Coriandrum sativum L. A piaceae. Ethnobot. Andes. 2020:1–7. doi: 10.1007/978-3-319-77093-2_79-1. [DOI] [Google Scholar]
  • 28.Musselman L.J. In: Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. 2nd ed. Leung A.T., Foster S., editors. Springer; New York, NY, USA: 1996. [Google Scholar]
  • 29.Platel K., Srinivasan K. Digestive stimulant action of spices: A myth or reality? Indian J. Med. Res. 2004;119:167–179. [PubMed] [Google Scholar]
  • 30.Otoom S., Al-Safi S., Kerem Z., Alkofahi A. The use of medicinal herbs by diabetic Jordanian patients. J. Herb. Pharmacother. 2006;6:31–41. doi: 10.1080/J157v06n02_03. [DOI] [PubMed] [Google Scholar]
  • 31.Tahraoui A., El-Hilaly J., Israili Z., Lyoussi B. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province) J. Ethnopharmacol. 2007;110:105–117. doi: 10.1016/j.jep.2006.09.011. [DOI] [PubMed] [Google Scholar]
  • 32.Al-Rowais N.A. Herbal medicine in the treatment of diabetes mellitus. Saudi Med. J. 2002;23:1327–1331. [PubMed] [Google Scholar]
  • 33.Chaudhry N., Tariq P. Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates. Pak. J. Pharm. Sci. 2006;19:214–218. [PubMed] [Google Scholar]
  • 34.Ugulu I., Baslar S., Yorek N., Dogan Y. The investigation and quantitative ethnobotanical evaluation of medicinal plants used around Izmir province, Turkey. J. Med. Plants Res. 2009;3:345–367. [Google Scholar]
  • 35.Emamghoreishi M., Heidari-Hamedani G. Anticonvulsant effect of extract and essential oil of Coriandrum sativum seed in conscious mice. Iran. J. Pharm. Res. 2004;3:71. [Google Scholar]
  • 36.Emamghoreishi M., Heidari-Hamedani G. Sedative-hypnotic activity of extracts and essential oil of Coriander seeds. Iran. J. Med. Sci. 2006;31:22–27. [Google Scholar]
  • 37.Aissaoui A., El-Hilaly J., Israili Z.H., Lyoussi B. Acute diuretic effect of continuous intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats. J. Ethnopharmacol. 2008;115:89–95. doi: 10.1016/j.jep.2007.09.007. [DOI] [PubMed] [Google Scholar]
  • 38.Taherian A.A., Vafaei A.A., Ameri J. Opiate system mediate the antinociceptive effects of Coriandrum sativum in mice. Iran. J. Pharm. Res. 2012;11:679. [PMC free article] [PubMed] [Google Scholar]
  • 39.Wichtl M. In: Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis. Wichtl M., editor. Medpharm GmbH Scientific Publishers; Stuttgart, Germany: 2004. [Google Scholar]
  • 40.Khare C.P. Indian Medicinal Plants: An Illustrated Dictionary. Springer Science & Business Media; Berlin/Heidelberg, Germany: 2008. [Google Scholar]
  • 41.Grieve M. A Modern Herbal. Volume 2 Courier Corporation; North Chelmsford, MA, USA: 2013. [Google Scholar]
  • 42.Hassar M. La phytothérapie au Maroc. Espérance Médicale. 1999;6:83–85. [Google Scholar]
  • 43.Bashir S., Safdar A. Coriander Seeds: Ethno-medicinal, Phytochemical and Pharmacological Profile. Sci. Spices Culin. Herbs-Latest Lab. Pre-Clin. Clin. Stud. 2020;2:39–64. [Google Scholar]
  • 44.Chauhan P., Jaryal M., Kumari K., Singh M. Phytochemical and in vitro Antioxidant Potential of Aqueous Leaf Extracts of Brassica juncea and Coriandrum sativum. World Vegetable Center; Tainan, Taiwan: 2012. [Google Scholar]
  • 45.Ishikawa T., Kondo K., Kitajima J. Water-soluble constituents of coriander. Chem. Pharm. Bull. 2003;51:32–39. doi: 10.1248/cpb.51.32. [DOI] [PubMed] [Google Scholar]
  • 46.Barros L., Duenas M., Dias M.I., Sousa M.J., Santos-Buelga C., Ferreira I.C. Phenolic profiles of in vivo and in vitro grown Coriandrum sativum L. Food Chem. 2012;132:841–848. doi: 10.1016/j.foodchem.2011.11.048. [DOI] [Google Scholar]
  • 47.Oganesyan E., Nersesyan Z., Parkhomenko A.Y. Chemical composition of the above-ground part of Coriandrum sativum. Pharm. Chem. J. 2007;41:149–153. doi: 10.1007/s11094-007-0033-2. [DOI] [Google Scholar]
  • 48.Rahimi A.R., Babaei S., Mashayekhi K., Rokhzadi A., Amini S. Anthocyanin content of coriander (Coriandrum sativum L.) leaves as affected by salicylic acid and nutrients application. IJB. 2013;3:141–145. doi: 10.12692/ijb/3.2.141-145. [DOI] [Google Scholar]
  • 49.Patel D.K., Desai S.N., Gandhi H.P., Devkar R.V., Ramachandran A.V. Cardio protective effect of Coriandrum sativum L. on isoproterenol induced myocardial necrosis in rats. Food Chem. Toxicol. 2012;50:3120–3125. doi: 10.1016/j.fct.2012.06.033. [DOI] [PubMed] [Google Scholar]
  • 50.Jabeen Q., Bashir S., Lyoussi B., Gilani A.H. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J. Ethnopharmacol. 2009;122:123–130. doi: 10.1016/j.jep.2008.12.016. [DOI] [PubMed] [Google Scholar]
  • 51.Rehman N., Jahan N., ul-Rahman K., Khan K.M., Zafar F. Anti-arrhythmic potential of Coriandrum sativum seeds in salt induced arrhythmic rats. Pak. Vet. J. 2016;36:465–471. [Google Scholar]
  • 52.Shrirame B., Geed S., Raj A., Prasad S., Rai M., Singh A., Singh R., Rai B. Optimization of Supercritical Extraction of Coriander (Coriandrum sativum L.) Seed and Characterization of Essential Ingredients. J. Essent. Oil Bear. Plants. 2018;21:330–344. doi: 10.1080/0972060X.2018.1470943. [DOI] [Google Scholar]
  • 53.Coelho J.P., Cristino A.F., Matos P.G., Rauter A.P., Nobre B.P., Mendes R.L., Barroso J.G., Mainar A., Urieta J.S., Fareleira J.M., et al. Extraction of volatile oil from aromatic plants with supercritical carbon dioxide: Experiments and modeling. Molecules. 2012;17:10550–10573. doi: 10.3390/molecules170910550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 54.Sourmaghi M.H., Kiaee G., Golfakhrabadi F., Jamalifar H., Khanavi M. Comparison of essential oil composition and antimicrobial activity of Coriandrum sativum L. extracted by hydrodistillation and microwave-assisted hydrodistillation. J. Food Sci. Technol. 2015;52:2452–2457. doi: 10.1007/s13197-014-1286-x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 55.Coşkuner Y., Karababa E. Physical properties of coriander seeds (Coriandrum sativum L.) J. Food Eng. 2007;80:408–416. doi: 10.1016/j.jfoodeng.2006.02.042. [DOI] [Google Scholar]
  • 56.Burdock G.A., Carabin I.G. Safety assessment of coriander (Coriandrum sativum L.) essential oil as a food ingredient. Food Chem. Toxicol. 2009;47:22–34. doi: 10.1016/j.fct.2008.11.006. [DOI] [PubMed] [Google Scholar]
  • 57.Msaada K., Hosni K., Taarit M.B., Chahed T., Kchouk M.E., Marzouk B. Changes on essential oil composition of coriander (Coriandrum sativum L.) fruits during three stages of maturity. Food Chem. 2007;102:1131–1134. doi: 10.1016/j.foodchem.2006.06.046. [DOI] [Google Scholar]
  • 58.Zoubiri S., Baaliouamer A. Essential oil composition of Coriandrum sativum seed cultivated in Algeria as food grains protectant. Food Chem. 2010;122:1226–1228. doi: 10.1016/j.foodchem.2010.03.119. [DOI] [Google Scholar]
  • 59.Nejad Ebrahimi S., Hadian J., Ranjbar H. Essential oil compositions of different accessions of Coriandrum sativum L. from Iran. Nat. Prod. Res. 2010;24:1287–1294. doi: 10.1080/14786410903132316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 60.Bhuiyan M.N.I., Begum J., Sultana M. Chemical composition of leaf and seed essential oil of Coriandrum sativum L. from Bangladesh. Bangladesh J. Pharmacol. 2009;4:150–153. doi: 10.3329/bjp.v4i2.2800. [DOI] [Google Scholar]
  • 61.Eikani M.H., Golmohammad F., Rowshanzamir S. Subcritical water extraction of essential oils from coriander seeds (Coriandrum sativum L.) J. Food Eng. 2007;80:735–740. doi: 10.1016/j.jfoodeng.2006.05.015. [DOI] [Google Scholar]
  • 62.Msaada K., Taârit M.B., Hosni K., Salem N., Tammar S., Bettaieb I., Hammami M., Limam F., Marzouk B. Comparison of Different Extraction Methods for the Determination of Essential oils and Related Compounds from Coriander (Coriandrum sativum L.) Acta Chim. Slov. 2012;59:803–813. [PubMed] [Google Scholar]
  • 63.Benyoussef E.H., Saibi S. Influence of essential oil composition on water distillation kinetics. Flavour Fragr. J. 2013;28:300–308. doi: 10.1002/ffj.3169. [DOI] [Google Scholar]
  • 64.HuaSong S., Yue Z., WenZhong Z., ShengQiang D., Kai S., ZhongXiao T., Yan Y., Ying H. Changes of volatile components in Eryngium foetidum L. and Yunnan Coriandrum sativum L. with different plant organs. Food Res. Dev. 2016;37:161–165. [Google Scholar]
  • 65.Chung I.-M., Ahmad A., Kim S.-J., Naik P.M., Nagella P. Composition of the essential oil constituents from leaves and stems of Korean Coriandrum sativum and their immunotoxicity activity on the Aedes aegypti L. Immunopharmacol. Immunotoxicol. 2012;34:152–156. doi: 10.3109/08923973.2011.589030. [DOI] [PubMed] [Google Scholar]
  • 66.Orav A., Arak E., Raal A. Essential oil composition of Coriandrum sativum L. fruits from different countries. J. Essent. Oil Bear. Plants. 2011;14:118–123. doi: 10.1080/0972060X.2011.10643910. [DOI] [Google Scholar]
  • 67.Gil A., De La Fuente E.B., Lenardis A.E., López Pereira M., Suárez S.A., Bandoni A., Van Baren C., Di Leo Lira P., Ghersa C.M. Coriander essential oil composition from two genotypes grown in different environmental conditions. J. Agric. Food Chem. 2002;50:2870–2877. doi: 10.1021/jf011128i. [DOI] [PubMed] [Google Scholar]
  • 68.Saygi K.O. Quantification of Phenolics from Coriandrum sativum vulgare and Coriandrum sativum microcarpum by HPLC–DAD. Iran. J. Sci. Technol. Trans. A Sci. 2021;45:1319–1326. doi: 10.1007/s40995-021-01132-1. [DOI] [Google Scholar]
  • 69.Divya P., Puthusseri B., Neelwarne B. Carotenoid content, its stability during drying and the antioxidant activity of commercial coriander (Coriandrum sativum L.) varieties. Food Res. Int. 2012;45:342–350. doi: 10.1016/j.foodres.2011.09.021. [DOI] [Google Scholar]
  • 70.Sriti J., Wannes W.A., Talou T., Mhamdi B., Hamdaoui G., Marzouk B. Lipid, fatty acid and tocol distribution of coriander fruit’s different parts. Ind. Crops Prod. 2010;31:294–300. doi: 10.1016/j.indcrop.2009.11.006. [DOI] [Google Scholar]
  • 71.Sriti J., Talou T., Wannes W.A., Cerny M., Marzouk B. Essential oil, fatty acid and sterol composition of Tunisian coriander fruit different parts. J. Sci. Food Agric. 2009;89:1659–1664. doi: 10.1002/jsfa.3637. [DOI] [Google Scholar]
  • 72.Suttisansanee U., Thiyajai P., Chalermchaiwat P., Wongwathanarat K., Pruesapan K., Charoenkiatkul S., Temviriyanukul P. Phytochemicals and In Vitro Bioactivities of Aqueous Ethanolic Extracts from Common Vegetables in Thai Food. Plants. 2021;10:1563. doi: 10.3390/plants10081563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 73.Kajal A., Singh R. Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy in experimental rats via AGEs inhibition. PLoS ONE. 2019;14:e0213147. doi: 10.1371/journal.pone.0213147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 74.Singh R., Kaur N., Kishore L., Gupta G.K. Management of diabetic complications: A chemical constituents based approach. J. Ethnopharmacol. 2013;150:51–70. doi: 10.1016/j.jep.2013.08.051. [DOI] [PubMed] [Google Scholar]
  • 75.Hajlaoui H., Arraouadi S., Noumi E., Aouadi K., Adnan M., Khan M.A., Kadri A., Snoussi M. Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination. Molecules. 2021;26:3625. doi: 10.3390/molecules26123625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 76.Cha J.M., Yoon D., Kim S.Y., Kim C.S., Lee K.R. Neurotrophic and anti-neuroinflammatory constituents from the aerial parts of Coriandrum sativum. Bioorganic Chem. 2020;105:104443. doi: 10.1016/j.bioorg.2020.104443. [DOI] [PubMed] [Google Scholar]
  • 77.Ramadan M.F., Amer M.M.A., Awad A.E.S. Coriander (Coriandrum sativum L.) seed oil improves plasma lipid profile in rats fed a diet containing cholesterol. Eur. Food Res. Technol. 2008;227:1173–1182. doi: 10.1007/s00217-008-0833-y. [DOI] [Google Scholar]
  • 78.Ananthan R., Latha M., Ramkumar K., Pari L., Baskar C., Bai V.N. Modulatory effects of Gymnema montanum leaf extract on alloxan-induced oxidative stress in Wistar rats. Nutrition. 2004;20:280–285. doi: 10.1016/j.nut.2003.11.016. [DOI] [PubMed] [Google Scholar]
  • 79.Sharma N., Sharma P., Jasuja N.D., Joshi S.C. Ameliorative efficiency of Coriandrum sativum seed extract on atherosclerosis and oxidative stress in male albino hyperlipidemic rabbits. Res. J. Pharm. Biol. Chem. Sci. 2014;5:26–39. [Google Scholar]
  • 80.Lal A.A., Kumar T., Murthy P.B., Pillai K.S. Hypolipidemic effect of Coriandrum sativum L. in triton-induced hyperlipidemic rats. Indian J. Exp. Biol. 2004;42:909–912. [PubMed] [Google Scholar]
  • 81.Zeb F., Safdar M., Fatima S., Khan S., Alam S., Muhammad M., Syed A., Habib F., Shakoor H. Supplementation of garlic and coriander seed powder: Impact on body mass index, lipid profile and blood pressure of hyperlipidemic patients. Pak. J. Pharm. Sci. 2018;31:1935–1941. [PubMed] [Google Scholar]
  • 82.Rajeshwari U., Shobha I., Andallu B. Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities. Spatula DD Peer Rev. J. Complement. Med. Drug Discov. 2011;1:9–16. doi: 10.5455/spatula.20110106123144. [DOI] [Google Scholar]
  • 83.Aissaoui A., Zizi S., Israili Z.H., Lyoussi B. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J. Ethnopharmacol. 2011;137:652–661. doi: 10.1016/j.jep.2011.06.019. [DOI] [PubMed] [Google Scholar]
  • 84.Chaudhary S.K., Maity N., Nema N.K., Bhadra S., Saha B.P., Mukherjee P.K. Angiotensin converting enzyme inhibition activity of fennel and coriander oils from India. Nat. Prod. Commun. 2013;8:671–672. doi: 10.1177/1934578X1300800531. [DOI] [Google Scholar]
  • 85.Afsheen N., Khalil Ur R., Jahan N., Khan K.M., Zia M.A. Optimization of cardioprotective potential of various concentrations of medicinal plants by using response surface methodology. Pak. Vet. J. 2019;39:13–18. doi: 10.29261/pakvetj/2018.111. [DOI] [Google Scholar]
  • 86.Dhanapakiam P., Joseph J.M., Ramaswamy V.K., Moorthi M., Kumar A.S. The cholesterol lowering property of coriander seeds (Coriandrum sativum): Mechanism of action. J. Environ. Biol. 2008;29:53–56. [PubMed] [Google Scholar]
  • 87.Dhyani N., Parveen A., Siddiqi A., Hussain M.E., Fahim M. Cardioprotective Efficacy of Coriandrum sativum (L.) Seed Extract in Heart Failure Rats Through Modulation of Endothelin Receptors and Antioxidant Potential. J. Diet. Suppl. 2020;17:13–26. doi: 10.1080/19390211.2018.1481483. [DOI] [PubMed] [Google Scholar]
  • 88.Chithra V., Leelamma S. Hypolipidemic effect of coriander seeds (Coriandrum sativum): Mechanism of action. Plant Foods Hum. Nutr. 1997;51:167–172. doi: 10.1023/A:1007975430328. [DOI] [PubMed] [Google Scholar]
  • 89.Patel D., Desai S., Gajaria T., Devkar R., Ramachandran A.V. Coriandrum sativum L. seed extract mitigates lipotoxicity in raw 264.7 cells and prevents atherogenic changes in rats. EXCLI J. 2013;12:313–334. [PMC free article] [PubMed] [Google Scholar]
  • 90.Kousar S., Jahan N., Khalil Ur R., Nosheen S. Antilipidemic activity of Coriandrum sativum. Biosci. Res. 2011;8:8–14. [Google Scholar]
  • 91.Wang X., Zhu C., Peng T., Zhang W., Zhang J., Liu H., Wu C., Pan X., Wu C. Enhanced stability of an emulsion enriched in unsaturated fatty acids by dual natural antioxidants fortified in both the aqueous and oil phases. Food Hydrocoll. 2018;82:322–328. doi: 10.1016/j.foodhyd.2018.02.012. [DOI] [Google Scholar]
  • 92.Froyen E. The effects of fat consumption on low-density lipoprotein particle size in healthy individuals: A narrative review. Lipids Health Dis. 2021;20:86. doi: 10.1186/s12944-021-01501-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 93.Bays H. Clinical overview of Omacor: A concentrated formulation of omega-3 polyunsaturated fatty acids. Am. J. Cardiol. 2006;98:71i–76i. doi: 10.1016/j.amjcard.2005.12.029. [DOI] [PubMed] [Google Scholar]
  • 94.Colin A., Reggers J., Castronovo V., Ansseau M. Lipids, depression and suicide. Encephale. 2003;29:49–58. [PubMed] [Google Scholar]
  • 95.Bao L., Hu L., Zhang Y., Wang Y.I. Hypolipidemic effects of flavonoids extracted from Lomatogonium rotatum. Exp. Med. 2016;11:1417–1424. doi: 10.3892/etm.2016.3038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 96.Plösch T., Kruit J.K., Bloks V.W., Huijkman N.C., Havinga R., Duchateau G.S., Lin Y., Kuipers F. Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter. J. Nutr. 2006;136:2135–2140. doi: 10.1093/jn/136.8.2135. [DOI] [PubMed] [Google Scholar]
  • 97.Hwang G.-H., Heo Y.-R., Lee H.-J., Park O.-J., Kang S.-K., Kim Y.-D. Effects of Coriandrum sativum L. on lipid metabolism in rats with hypertriglyceridemic diet. Nutr. Sci. 2001;4:13–19. [Google Scholar]
  • 98.Sriti J., Wannes W.A., Talou T., Mhamdi B., Cerny M., Marzouk B. Lipid profiles of Tunisian coriander (Coriandrum sativum) seed. J. Am. Oil Chem. Soc. 2010;87:395–400. doi: 10.1007/s11746-009-1505-1. [DOI] [Google Scholar]
  • 99.Batta A.K., Xu G., Honda A., Miyazaki T., Salen G. Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat. Metabolism. 2006;55:292–299. doi: 10.1016/j.metabol.2005.08.024. [DOI] [PubMed] [Google Scholar]
  • 100.Kong C.K., Low L.E., Siew W.S., Yap W.H., Khaw K.Y., Ming L.C., Mocan A., Goh B.H., Goh P.H. Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae) Front. Pharm. 2020;11:552453. doi: 10.3389/fphar.2020.552453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 101.Anmol R.J., Marium S., Hiew F.T., Han W.C., Kwan L.K., Wong A.K.Y., Khan F., Sarker M.M.R., Chan S.Y., Kifli N., et al. Phytochemical and Therapeutic Potential of Citrus grandis (L.) Osbeck: A Review. J. Evid. Based Integr. Med. 2021;26 doi: 10.1177/2515690X211043741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 102.Weber C., Noels H. Atherosclerosis: Current pathogenesis and therapeutic options. Nat. Med. 2011;17:1410–1422. doi: 10.1038/nm.2538. [DOI] [PubMed] [Google Scholar]
  • 103.Glass C.K., Witztum J.L. Atherosclerosis: The road ahead. Cell. 2001;104:503–516. doi: 10.1016/S0092-8674(01)00238-0. [DOI] [PubMed] [Google Scholar]
  • 104.Greaves D.R., Gough P.J., Gordon S. Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence. Curr. Opin. Lipidol. 1998;9:425–432. doi: 10.1097/00041433-199810000-00006. [DOI] [PubMed] [Google Scholar]
  • 105.Björkerud B., Björkerud S.r. Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts. Arterioscler. Thromb. Vasc. Biol. 1996;16:416–424. doi: 10.1161/01.ATV.16.3.416. [DOI] [PubMed] [Google Scholar]
  • 106.Sreelatha S., Inbavalli R. Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats. J. Food Sci. 2012;77:T119–T123. doi: 10.1111/j.1750-3841.2012.02755.x. [DOI] [PubMed] [Google Scholar]
  • 107.Dianat M., Negin A., Mohammad B., Yaghoub F. Antidysrhythmic, inotropic and chronotropic effects of ellagic acid and forced exercise in rat. Res. J. Pharm. Biol. Chem. Sci. 2014;5:1549–1557. [Google Scholar]
  • 108.Ramadan M.F., Moersel J.-T. Screening of the antiradical action of vegetable oils. J. Food Compos. Anal. 2006;19:838–842. doi: 10.1016/j.jfca.2006.02.013. [DOI] [Google Scholar]
  • 109.Potter T.L. Essential oil composition of cilantro. J. Agric. Food Chem. 1996;44:1824–1826. doi: 10.1021/jf950814c. [DOI] [Google Scholar]
  • 110.Abiko Y., Kumagai Y. Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic. Arsen. Contam. Asia. 2019:151–161. doi: 10.1007/978-981-13-2565-6_9. [DOI] [Google Scholar]
  • 111.Mazimba O. Umbelliferone: Sources, chemistry and bioactivities review. Bull. Fac. Pharm. Cairo Univ. 2017;55:223–232. doi: 10.1016/j.bfopcu.2017.05.001. [DOI] [Google Scholar]
  • 112.Ali F.E., Hassanein E.H., El-Bahrawy A.H., Omar Z.M., Rashwan E.K., Abdel-Wahab B.A., Abd-Elhamid T.H. Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF-kB-p65 signaling pathways. J. Biochem. Mol. Toxicol. 2021;35:e22738. doi: 10.1002/jbt.22738. [DOI] [PubMed] [Google Scholar]
  • 113.Webster K.A. Mitochondrial membrane permeabilization and cell death during myocardial infarction: Roles of calcium and reactive oxygen species. Future Cardiol. 2012;8:863–884. doi: 10.2217/fca.12.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 114.Nwagha U., Ikekpeazu E., Ejezie F., Neboh E., Maduka I. Atherogenic index of plasma as useful predictor of cardiovascular risk among postmenopausal women in Enugu, Nigeria. Afr. Health Sci. 2010;10:248–252. [PMC free article] [PubMed] [Google Scholar]
  • 115.Boers M., Nurmohamed M.T., Doelman C.J., Lard L.R., Verhoeven A.C., Voskuyl A.E., Huizinga T.W., van de Stadt R.J., Dijkmans B.A., van der Linden S. Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis. Ann. Rheum. Dis. 2003;62:842–845. doi: 10.1136/ard.62.9.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 116.Georgiadis A.N., Papavasiliou E.C., Lourida E.S., Alamanos Y., Kostara C., Tselepis A.D., Drosos A.A. Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: Effect of early treatment—A prospective, controlled study. Arthritis Res. Ther. 2006;8:1–7. doi: 10.1186/ar1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 117.Pihlanto A., Akkanen S., Korhonen H.J. ACE-inhibitory and antioxidant properties of potato (Solanum tuberosum) Food Chem. 2008;109:104–112. doi: 10.1016/j.foodchem.2007.12.023. [DOI] [PubMed] [Google Scholar]
  • 118.Daskaya-Dikmen C., Yucetepe A., Karbancioglu-Guler F., Daskaya H., Ozcelik B. Angiotensin-I-converting enzyme (ACE)-inhibitory peptides from plants. Nutrients. 2017;9:316. doi: 10.3390/nu9040316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 119.Liu M., Du M., Zhang Y., Xu W., Wang C., Wang K., Zhang L. Purification and identification of an ACE inhibitory peptide from walnut protein. J. Agric. Food Chem. 2013;61:4097–4100. doi: 10.1021/jf4001378. [DOI] [PubMed] [Google Scholar]
  • 120.Nazni P., Dharmaligam R. Isolation and separation of phenolic compound from coriander flowers. Int. J. Agric. Food Sci. 2014;4:13–21. [Google Scholar]
  • 121.Rajeshwari C., Andallu B. Isolation and simultaneous detection of flavonoids in the methanolic and ethanolic extracts of Coriandrum sativum L. seeds by RP-HPLC. Pak. J. Food Sci. 2011;21:13–21. [Google Scholar]
  • 122.Msaada K., Jemia M.B., Salem N., Bachrouch O., Sriti J., Tammar S., Bettaieb I., Jabri I., Kefi S., Limam F. Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arab. J. Chem. 2017;10:S3176–S3183. doi: 10.1016/j.arabjc.2013.12.011. [DOI] [Google Scholar]
  • 123.Luo J., Zhang C., Liu Q., Ou S., Zhang L., Peng X. Combinative effect of sardine peptides and quercetin alleviates hypertension through inhibition of angiotensin I converting enzyme activity and inflammation. Food Res. Int. 2017;100:579–585. doi: 10.1016/j.foodres.2017.07.019. [DOI] [PubMed] [Google Scholar]
  • 124.Oyagbemi A.A., Omobowale T.O., Ola-Davies O.E., Asenuga E.R., Ajibade T.O., Adejumobi O.A., Afolabi J.M., Ogunpolu B.S., Falayi O.O., Ayodeji F. Ameliorative effect of Rutin on sodium fluoride-induced hypertension through modulation of Kim-1/NF-κB/Nrf2 signaling pathway in rats. Environ. Toxicol. 2018;33:1284–1297. doi: 10.1002/tox.22636. [DOI] [PubMed] [Google Scholar]
  • 125.Gao H.-L., Yu X.-J., Hu H.-B., Yang Q.-W., Liu K.-L., Chen Y.-M., Zhang Y., Zhang D.-D., Tian H., Zhu G.-Q. Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovasc. Toxicol. 2021;21:721–736. doi: 10.1007/s12012-021-09662-1. [DOI] [PubMed] [Google Scholar]
  • 126.Oyagbemi A.A., Omobowale T.O., Ola-Davies O.E., Asenuga E.R., Ajibade T.O., Adejumobi O.A., Afolabi J.M., Ogunpolu B.S., Falayi O.O., Saba A.B., et al. Luteolin-mediated Kim-1/NF-kB/Nrf2 signaling pathways protects sodium fluoride-induced hypertension and cardiovascular complications. Biofactors. 2018;44:518–531. doi: 10.1002/biof.1449. [DOI] [PubMed] [Google Scholar]
  • 127.Loizzo M.R., Said A., Tundis R., Rashed K., Statti G.A., Hufner A., Menichini F. Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb)(Simaroubaceae) Phytother. Res. Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv. 2007;21:32–36. doi: 10.1002/ptr.2008. [DOI] [PubMed] [Google Scholar]
  • 128.Chen C.-H., Lin J.-Y., Lin C.-N., Hsu S.-Y. Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum. J. Nat. Prod. 1992;55:691–695. doi: 10.1021/np50083a025. [DOI] [PubMed] [Google Scholar]
  • 129.Bormann H., Melzig M. Inhibition of metallopeptidases by flavonoids and related compounds. Die Pharm. 2000;55:129–132. [PubMed] [Google Scholar]
  • 130.Lacaille-Dubois M., Franck U., Wagner H. Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine. 2001;8:47–52. doi: 10.1078/0944-7113-00003. [DOI] [PubMed] [Google Scholar]
  • 131.Epstein M. Calcium Antagonists in Clinical Medicine. Volume 183 Hanley Belfus Inc.; Phila, PA, USA: 1992. [Google Scholar]
  • 132.Chiu A.T., McCall D.E., Timmermans P.B. Pharmacological characteristics of receptor-operated and potential-operated Ca2+ channels in rat aorta. Eur. J. Pharmacol. 1986;127:1–8. doi: 10.1016/0014-2999(86)90199-8. [DOI] [PubMed] [Google Scholar]
  • 133.Mendel B., Christianto, Setiawan M., Prakoso R., Siagian S.N. A Comparative Effectiveness Systematic Review and Meta-Analysis of Drugs for the Prophylaxis of Junctional Ectopic Tachycardia. Curr. Cardiol. Rev. 2021 doi: 10.2174/1573403X17666210603113430. [DOI] [PMC free article] [PubMed] [Google Scholar]

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