Table 1. Monoclonal antibody (mAb) binding to biofilm and planktonic bacteria.
Significant binding (p<0.05) of IgG1 mAbs compared to control IgG1 s indicated with ‘+,’ weak binding (p<0.05, p<0.99) is indicated with ‘+/-,’ and no significant binding (p>0.99) is indicated with ‘–.’.
| Clone | Target | Biofilm | Planktonic | ||
|---|---|---|---|---|---|
| PNAG (+) | PNAG (-) | Wood46 | LAC ∆spa∆sbi | ||
| F598 | PNAG | + | – | +/- | – |
| 4461 | WTA(α) | +/- | + | – | + |
| 4497 | WTA(β) | + | + | + | +/- |
| CR5132 | WTA(β) | + | + | +/- | + |
| rF1 | SDR proteins | + | + | + | + |
| T1-2 | ClfA | +/- | + | +/- | +/- |
PNAG, poly-N-acetyl glucosamine; WTA, wall teichoic acid; SDR, serine-aspartate dipeptide repeats; ClfA, clumping factor B.