Figure 6.

Schematic of the model. The model consists of a lung model which incorporates viral infection of epithelial and endothelial cells and the innate immune response which includes classical and trans IL6 pathways, other inflammatory cytokines, activity of neutrophils, and macrophages, as well as the formation of NETs, and the coagulation cascade and activation of the renin-angiotensin system (RAS). In addition the model contains terms describing the adaptive immune response including conversion of dendritic cells to antigen presenting cells, formation of activated B-cells, antibody levels, T cell activation and immune checkpoints, The lung model is coupled with a PK/PD model for the virus and thrombi dissemination through the body.