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. 2022 Jan 13;11(1):2025668. doi: 10.1080/2162402X.2022.2025668

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Mutual influx of T-cell clones between tumor and peripheral blood T cells.

(a) Morisita-Horn (MH) overlap index between tumors and peripheral CD8⁺ T cells. (b) Increased MH overlap index was associated with progressive-free survival. (c) Clonotypes shared between tumors and peripheral CD8⁺ T cells at baseline and during treatment. The new on-treatment TCR clonotypes firstly shared between tumors and peripheral CD8⁺ T cells during treatment. (d) Representative upset Venn diagram to assess unique TCR clonotypes in tumors and peripheral CD8⁺ T cells both at baseline and during treatment. Each row, unique clonotypes in individual tested samples. Each column, intersection set (shared clonotypes) or exception set (peculiar clonotypes) between samples. UpSetR (version 1.4.0) packages was used. (e) Different derivation of new shared clonotypes during treatment. (f) New shared clonotypes in baseline samples. N = 14. P < .05, significant difference.