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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Neurotoxicology. 2021 Sep 17;87:94–105. doi: 10.1016/j.neuro.2021.09.002

Figure 1.

Figure 1.

Acute Mn exposure study. (A) Experimental timeline. At 12 weeks of age, mice were injected [0, 10, 20, or 50 mg/kg MnCl2 • 4(H2O)] 3 times over the course of one week (days 1, 4, and 7) and sacrificed 24 hours following the third injection (day 8). (B) ARG2 protein expression increased following Mn exposure in both genotypes but a larger dose is required in YAC128 mice compared to WT. Pound symbol indicates significant difference from vehicle within a genotype by post-hoc Dunnett’s multiple comparisons. Mean ± S.E.M. plotted. ## p<0.01, ####p<0.0001. n=6-8 per genotype-treatment group, approximately equal males and females.