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. 2022 Jan 14;14(1):2020081. doi: 10.1080/19420862.2021.2020081

Figure 8.

Figure 8.

Evaluation of bioreactor fed-batch cell culture performance for parental CHO clones (CDE1a and CDE2a) and MMP-enriched clones (MDE1a and MDE2a) expressing DTE1 and DTE2. (a, b) Day 14 titers. (c,d) Specific productivity (Qp). (e,f) Viable cell density (VCD). (g,h) Viability. (i,j) Glucose consumed. (k,l) Lactate produced. Data represent mean ± SD (n = 2). *p < .05 by two-tailed Student’s t-test. The titer, specific productivity, viable cell density, viability, glucose consumption and lactate production of the selected clones expressing DTE1 and DTE2 in bioreactor fed-batch culture demonstrating improved performance of the MMP host-derived clones.