Table 1.

The proposed canonical and non-canonical signaling pathways of necroptosis.

Signaling Type		Proteins Involved	Reference
Canonical		RIP3–MLKL	[73,74,90,91]
Non-canonical	Associated with the mitochondria	RIP3–CaMKII	[35]
		RIP3–PGAM5–Drp-1	[85,86]
		RIP3–JNK–BNIP3	[89]
	Associated with the sarcoplasmic reticulum	RIP3–XO	[36]