FIGURE 3.

Correlations of functional connectivity of auditory naming (seed region: left inferior temporal gyrus) and picture naming (seed region: left fusiform gyrus) with lower free water fraction (FWF) of underlying white matter tracts. Areas of significant connectivity are shown superimposed on sagittal and coronal T1 images masked for the group effects at p < .001 uncorrected. Top row and second row: Auditory naming. Stronger functional connectivity correlated with lower FWF in the bilateral anterior superior temporal gyrus, transverse temporal (Heschl's) gyrus, and bilateral precentral gyrus in all groups. Scatterplot shows correlation of functional magnetic resonance imaging (fMRI) parameter estimates extracted from the left anterior superior temporal gyrus with mean FWF values. Controls had stronger correlations compared to left temporal lobe epilepsy (TLE; lingual gyrus) and right TLE (left middle temporal gyrus, left cerebellum [not shown on slice], bilateral lingual gyrus [not shown on slice]). Third row and bottom row: Picture naming. All groups had correlations of stronger functional connectivity with lower FWF in the left precentral gyrus. Scatterplot shows correlation of fMRI parameter estimates extracted from the left precentral gyrus with mean FWF values. Controls and right TLE patients had stonger correlations in the right inferior occipital gyrus compared to left TLE. A, anterior; L, left; P, posterior; R, right