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. 2021 Dec 29;14(1):76. doi: 10.3390/pharmaceutics14010076

Figure 7.

Figure 7

Bromelain-based treatment (BBT): (a) venous insufficiency ulcer; 1—pre-existing for 5 months, 2—after first BBT 4-h application, 3—after fourth BBT 4-h application (16 h total exposure to bromelain-based debridement), 4—one week post-split-thickness skin grafting, 5—seven weeks post-split-thickness skin grafting (Adapted with permission from [108], John Wiley and Sons, Hoboken, NJ, USA, 2018); (b) large venous leg ulcers; 1—venous leg ulcer pre-existing 10 weeks, 2—after 7 BBT, and 3—two months after split-thickness skin grafting (Reproduced with permission from [107], John Wiley and Sons, Hoboken, NJ, USA, 2021); (c) hand burn; 1—before BBT, 2—after BBT, 3—outcome 38 days post-burn (Reproduced with permission from [104], Baoshideng Publishing Group Inc., Pleasanton, CA, USA, 2017).