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. 2022 Jan 10;27(2):443. doi: 10.3390/molecules27020443

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Verification of promotion effect of miR-126-5p in nude mice transplantation experiment. (A) BALB/c nude mice were taken for xenotransplantation, and the size was measured by the ruler. (B) The body weight of nude mice showed significant intergroup difference due to tumor size. (C) The volume of anatomized subcutaneous xenograft tumors was measured and analyzed by Student’s t test. (D,E) Representative Ki-67, BAX, and VEGF immunohistochemical staining micrographs of xenograft tumors. Ki-67 and VEGF were significantly increased in the group 126m, while BAX was significantly reduced. The 126i group showed the opposite trend. Data are shown as mean ± SD, n = 3; * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. NC.