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One-pot multicomponent CuAAC and hydrolysis reaction. Reaction conditions: (1) 4 (0.5 mmol), 5a (0.5 mmol), NaN3 (0.7 mmol), CuNPs/C (0.5 mol%, 20 mg), H2O:MeOH (2 mL, 1:1), 85 °C, MW, 30 min. (2) NaOH solution (1 mL, 2 M), 120 °C, MW. (3) Yield of the one-pot multicomponent click reaction/basic hydrolysis. (4) Yield of the multicomponent click reaction and subsequent basic hydrolysis with intermediary ester purification. Yields indicate isolated products.
