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. 2021 Dec 27;14(1):45. doi: 10.3390/pharmaceutics14010045

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of MET+SM combination therapy on the relative mRNA expression of (A) hepatic cytochrome P450 family protein genes and (B) ABC transporters. Values are expressed as means ± SEM; n = 6 for HHTg/C, n = 7 for HHTg/MET, n = 8 for HHTg/MET+SM; * p < 0.05, ** p < 0.01, *** p < 0.001 probability reflecting the effect of MET monotherapy vs. the control group without treatment; ^† p < 0.05, ^†† p < 0.01, ^††† p < 0.001 probability reflecting the effect of MET therapy vs. MET+SM combination therapy.