Table 1.
Altered Immunometabolism | Significance | Potential Treatment | |
---|---|---|---|
Enhanced lipid uptake due to the upregulation of CD36/fatty acid transport protein | Activation of inflammasomes | Etomoxir CD36 blocker | A |
Enhanced glucose uptake | Enhanced glycolysis in naive B cells and altered glycosylation and function on immunoglobulin | 2DG or Glut1 inhibitors | B |
Increase mitochondrial mass and function | Increased inhibition of regulatory phosphatase due to mitochondrial ROS | Metformin | C |
ROS resistance | Resistance to metabolic stress | ROS inhibitor | D |