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. 2022 Jan 5;12(1):40. doi: 10.3390/metabo12010040

Table 1.

Altered immunometabolism, significance, and potential treatment for glycolysis, FAO, and OXPHOS. This Table was adapted from the article by Wilson, C.S. and Moore, D.J. [9].

Altered Immunometabolism Significance Potential Treatment
Enhanced lipid uptake due to the upregulation of CD36/fatty acid transport protein Activation of inflammasomes Etomoxir CD36 blocker A
Enhanced glucose uptake Enhanced glycolysis in naive B cells and altered glycosylation and function on immunoglobulin 2DG or Glut1 inhibitors B
Increase mitochondrial mass and function Increased inhibition of regulatory phosphatase due to mitochondrial ROS Metformin C
ROS resistance Resistance to metabolic stress ROS inhibitor D