Table 4.
Similarity factor analysis.
| Dissolution Apparatus. | USP 2 | Biorelevant | USP 2 vs. Biorelevant | ||||
|---|---|---|---|---|---|---|---|
| Compared Samples | f 2 | f 2 | Compared Samples | f 2 | |||
| M125/N75M50 | 73.05 | S * | 95.29 | S | M125/M125 | 47.48 | N |
| M125/N125 | 37.94 | N ** | 66.94 | S | N75M50/N75M50 | 58.66 | S |
| N75M50/N125 | 34.35 | N | 67.81 | S | N125/N125 | 29.28 | N |
| M100/N50M50 | 69.52 | S | 66.24 | S | M100/M100 | 40.01 | N |
| M100/N100 | 45.96 | N | 55.19 | S | N50M50/N50M50 | 55.45 | S |
| N50M50/N100 | 47.2 | N | 73.14 | S | N100/N100 | 40.31 | N |
| M75/N25M50 | 83.63 | S | 94.54 | S | M75/M75 | 36.31 | N |
| M75/N75 | 68.52 | S | 99.29 | S | N25M50/N25M50 | 37.9 | N |
| N25M50/N75 | 61.95 | S | 96.87 | S | N75/N75 | 38.98 | N |
* similar dissolution profile, ** non-similar dissolution profile.