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. 2021 Dec 31;14(1):69. doi: 10.3390/v14010069

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of binding affinity of NBCoV1 and NBCoV2 to SARS-CoV-2 active trimer and SARS-CoV-2 S1 subdomain by SPR. Kinetics fitting curve (sensogram) of SARS-CoV-2 trimer to (a) NBCoV1; (b) NBCoV2. Kinetics fitting curve (sensogram) of SARS-CoV-2 S1 subdomain to (c) NBCoV1 and (d) NBCoV2. The binding affinity K_D and kinetic parameters k_on and k_off of (e) NBCoV1 and NBCoV2.