Table 2.
Summary of the effects related to the mutation of genes encoding flagellar proteins or genes, related to their expression in Brucella.
| Mutant |
Brucella Species |
Effect | References |
|---|---|---|---|
| ΔftcR | B. melitensis | Decreases flagellar gene expression. | [68] |
| ΔvjBR | B. melitensis | Decrease flagellar proteins expression. | [74,78,79] |
| ΔblxR | B. abortus | Regulates virulence factors (TSSIV and flagella). | [73] |
| ΔbvrR/bvrS | B. abortus | Decreases virulence. | [80] |
| ΔftcR, ΔfliF, ΔflgE, ΔfliC | B.melitensis | Empty sheath. | [62] |
| ΔflgJ | B. abortus | Decreases biofilms, virulence and infection capacity. | [69] |
| ΔybeY (BAB1_2156) | B. abortus | Multiple dysregulations of expression of bacterial proteins, including proteins and flagellar regulators. | [77] |
| ΔfliF, ΔflhA, ΔmotB, ΔflgE | B. melitensis | Dysfunction is the first step of infection or cycle of life. | [46] |
| ΔaibP (QS gen) | B. melitensis | Expression of fliC, fliF, flgE y flbT was significantly downregulated, with enhanced virB genes expression and VirB8 production. | [63] |
| ΔBM-LOV-HK (light-sensing histidine kinase) |
B. melitensis | Sigma factor rpoE1 downregulated, with flagellar, quorum sensing (QS). Type-IV secretion system genes were upregulated. | [81] |
| ΔbpdA | B. melitensis | Downregulation of flagellar promoter activities. Attenuation of virulence. Increase in biofilms. | [82,83] |
| ΔRpoE1 | B. melitensis | Overexpresses the flagellar protein FlgE. Increases promoter activity of the flagellar master regulator ftcR. | [62] |