Table 1.
Target proteins investigated in the 3-hydroxyphenylacetic acid(3-HPAA) mechanistic studies and the ligands used in the ex vivo experiments on the porcine coronary artery.
| Targets | Ligands |
|---|---|
| Ion channels | |
| SKCa | UCL-1684 |
| IKCa | TRAM-34 |
| L-type Ca2+ channels (Cav1.2) | Bay K8644 |
| nifedipine | |
| Enzymes | |
| eNOS | L-NAME |
| cyclooxygenase | indomethacin |
| GPCRs | |
| M receptors | atropine |
SKCa, small-conductance calcium-activated potassium channels; IKCa, intermediate-conductance calcium-activated potassium channels; eNOS, endothelial nitric oxide synthase; GPCRs, G protein-coupled receptors; M receptors, muscarinic receptors; L-NAME, L-Nω-nitro arginine methyl ester. The subgroups of the targets are in bold.