Table 3.
Overview of all currently ongoing clinical trials of carrageenan against SARS-CoV-2 (listed at clinicaltrials.gov, accessed on 20 November 2021 ).
| Study Title | Identifier | Status | Results | Primary Outcome | |
|---|---|---|---|---|---|
| 1 | Study to Investigate if Sucking a Coldamaris Lozenge Elutes Sufficient Iota-carrageenan to Inactivate Usual Common Cold Viruses | NCT04533906 | Completed | Pending | Iota-carrageenan concentration in saliva |
| 2 | USEFULNESS of Topic Ivermectin and Carrageenan to Prevent Contagion of COVID 19 (IVERCAR) | NCT04425850 | Completed | Published | Number of participants testing positive for COVID-19 |
| 3 | Prophylaxis COVID-19 in Healthcare Agents by Intensive Treatment With Ivermectin and Iota-carrageenan (Ivercar-Tuc) | NCT04701710 | Completed | Pending | Number of subjects who were diagnosed with COVID-19 in EG and CG |
| 4 | Carrageenan Nasal Spray for COVID-19 Prophylaxis | NCT04590365 | Recruiting | Pending | Rate of COVID-19 infection |
| 5 | Efficacy of a Nasal Spray Containing Iota-Carrageenan in the Prophylaxis of COVID-19 Disease in Health Personnel Dedicated to Patients with COVID-19 Disease | NCT04521322 | Recruiting | Pending | Diagnosis of COVID19 disease |
| 6 | Effect of Local Treatment(Carrageenan Nasal Spray and PVP-I Mouthwash) in Reducing Viral Load in Patients With COVID-19 (LT-COVID19) | NCT05049213 | Recruiting | Pending | Change from baseline naso-pharyngeal viral load quantified by RT-PCR at Day 8 |
| 7 | Prophylactic Treatment With Carragelose Nasal Spray to Prevent SARS-CoV-2, COVID-19, Infections in Health Care Workers | NCT04681001 | Recruiting | Pending | Presence of COVID-19 symptoms including symptoms of respiratory viral infection |
| 8 | Efficacy and Safety Evaluation of Inhaleen Inhalation in Hospitalized COVID-19 Patients | NCT04793984 | Recruiting | Pending | Clinical status of subjects as expressed on the WHO-8-Category ordinal scale |