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Pharmacokinetic parameters of PAL, PAL-RES, and PAL-ORC.
| PAL | PAL in PAL-RES | PAL in PAL-ORC | |
|---|---|---|---|
| Cmax (ng/mL) | 346.69 | 371.57 | 233.46 |
| Tmax (h) | 4 | 4 | 4 |
| T1/2 (h) | 19.89 | 10.33 | 17.36 |
| Vd (L/kg) | 20.48 | 12.05 | 19.26 |
| MRT (h) | 5.36 | 5.73 | 6.15 |
| AUC0−t (ng∙h/mL) | 2616.48 | 3245.47 | 2254.08 |
| Frel | - | 1.24 | 0.86 |
