Table 4.
Effects of hemodialysis on free oxylipins in the CKD patients at cessation (post-HD) of hemodialysis (n = 12 each).
| Post-HD A (Mean ± SD) |
Post-HD V (Mean ± SD) |
p-Value, t-Test (# Paired Wilcoxon Test) |
Post-HD A-V Difference (Mean ± SD) |
|
|---|---|---|---|---|
| CYP epoxy-metabolites | ||||
| 5,6-EET | 0.2022 ± 0.0733 | 0.2317 ± 0.0812 | 0.303 | −0.0295 ± 0.0945 |
| 8,9-EET | 0.2672 ± 0.1586 | 0.2517 ± 0.1676 | 0.814 # | 0.0155 ± 0.1947 |
| 11,12-EET | 0.1754 ± 0.0675 | 0.2403 ± 0.1094 | 0.051 | −0.0649 ± 0.1029 |
| 14,15-EET | 0.2573 ± 0.1199 | 0.3791 ± 0.2067 | 0.049 | −0.1219 ± 0.1913 |
| 5,6-DHET | 0.0324 ± 0.0085 | 0.0321 ± 0.0104 | 0.814 # | 0.0002 ± 0.0047 |
| 8,9-DHET | 0.0910 ± 0.0281 | 0.0847 ± 0.0241 | 0.388 # | 0.0063 ± 0.0207 |
| 11,12-DHET | 0.1486 ± 0.0443 | 0.1454 ± 0.0379 | 0.631 | 0.0032 ± 0.0226 |
| 14,15-DHET | 0.2038 ± 0.0569 | 0.2062 ± 0.0477 | 0.854 | −0.0024 ± 0.0444 |
| 7,8-EDP | 0.1852 ± 0.1197 | 0.2412 ± 0.1309 | 0.076 | −0.0560 ± 0.0993 |
| 10,11-EDP | 0.1358 ± 0.0948 | 0.1805 ± 0.1004 | 0.079 | −0.0447 ± 0.0800 |
| 13,14-EDP | 0.1273 ± 0.0808 | 0.1452 ± 0.0769 | 0.439 | −0.0179 ± 0.0774 |
| 16,17-EDP | 0.1922 ± 0.0843 | 0.2284 ± 0.0893 | 0.124 | −0.0362 ± 0.0753 |
| 19,20-EDP | 0.2899 ± 0.1669 | 0.3587 ± 0.1754 | 0.096 | −0.0688 ± 0.1311 |
| 7,8-DiHDPA | 0.0234 ± 0.0210 | 0.0330 ± 0.0115 | 0.388 # | −0.0097 ± 0.0267 |
| 10,11-DiHDPA | 0.0581 ± 0.0148 | 0.0554 ± 0.0125 | 0.182 # | 0.0027 ± 0.0067 |
| 13,14-DiHDPA | 0.0696 ± 0.0222 | 0.0661 ± 0.0178 | 0.272 # | 0.0035 ± 0.0090 |
| 16,17-DiHDPA | 0.0865 ± 0.0293 | 0.0809 ± 0.0206 | 0.695 # | 0.0056 ± 0.0148 |
| 19,20-DiHDPA | 0.7042 ± 0.3142 | 0.6061 ± 0.2823 | 0.06 # | 0.0981 ± 0.1753 |
| 8,9-EEQ | 0.0663 ± 0.0419 | 0.0700 ± 0.0284 | 0.791 | −0.0037 ± 0.0472 |
| 11,12-EEQ | 0.0435 ± 0.0354 | 0.0490 ± 0.0252 | 0.388 # | −0.0055 ± 0.0418 |
| 14,15-EEQ | 0.0607 ± 0.0349 | 0.0655 ± 0.0298 | 0.651 | −0.0049 ± 0.0363 |
| 17,18-EEQ | 0.0830 ± 0.0590 | 0.0936 ± 0.0518 | 0.602 | −0.0106 ± 0.0684 |
| 5,6-DiHETE | 0.0980 ± 0.0508 | 0.0799 ± 0.0403 | 0.01 | 0.0181 ± 0.0322 |
| 8,9-DiHETE | 0.0233 ± 0.0063 | 0.0202 ± 0.0041 | 0.174 | 0.0031 ± 0.0074 |
| 11,12-DiHETE | 0.0160 ± 0.0026 | 0.0155 ± 0.0023 | 0.461 | 0.0004 ± 0.0020 |
| 14,15-DiHETE | 0.0181 ± 0.0080 | 0.0167 ± 0.0073 | 0.525 | 0.0015 ± 0.0078 |
| 17,18-DiHETE | 0.1661 ± 0.0704 | 0.1476 ± 0.0603 | 0.337 | 0.0185 ± 0.0640 |
| 9,10-EpOME | 4.6969 ± 3.1153 | 6.2952 ± 5.0363 | 0.182 # | −1.5984 ± 3.6422 |
| 12,13-EpOME | 6.8441 ± 3.8513 | 8.4182 ± 6.5171 | 0.239 # | −1.5740 ± 4.1754 |
| 9,10-DiHOME | 1.7695 ± 1.1345 | 1.7400 ± 1.1665 | 0.754 # | 0.0295 ± 0.2442 |
| 12,13-DiHOME | 3.3260 ± 2.0952 | 3.4845 ± 2.2350 | 0.347 # | −0.1585 ± 0.4498 |
| LOX metabolites | ||||
| 5-HETE | 0.1100 ± 0.0465 | 0.1147 ± 0.0494 | 0.365 | −0.0046 ± 0.0169 |
| 8-HETE | 0.0672 ± 0.0281 | 0.0667 ± 0.0298 | 0.943 | 0.0006 ± 0.0273 |
| 9-HETE | 0.1016 ± 0.0158 | 0.1058 ± 0.0218 | 0.31 | −0.0042 ± 0.0136 |
| 11-HETE | 0.0739 ± 0.0265 | 0.0800 ± 0.0305 | 0.262 | −0.0061 ± 0.0180 |
| 12-HETE | 0.5660 ± 0.3630 | 0.4319 ± 0.2449 | 0.094 | 0.1341 ± 0.2531 |
| 15-HETE | 0.1789 ± 0.0583 | 0.1841 ± 0.0689 | 0.536 | −0.0052 ± 0.0282 |
| 4-HDHA | 0.0821 ± 0.0209 | 0.0844 ± 0.0239 | 0.695 # | −0.0023 ± 0.0109 |
| 7-HDHA | 0.0852 ± 0.0189 | 0.0875 ± 0.0186 | 0.594 | −0.0024 ± 0.0148 |
| 8-HDHA | 0.0779 ± 0.0221 | 0.0763 ± 0.0241 | 0.584 | 0.0016 ± 0.0098 |
| 10-HDHA | 0.0622 ± 0.0148 | 0.0636 ± 0.0173 | 0.658 | −0.0014 ± 0.0105 |
| 11-HDHA | 0.0722 ± 0.0107 | 0.0766 ± 0.0117 | 0.081 | −0.0044 ± 0.0079 |
| 13-HDHA | 0.0653 ± 0.0131 | 0.0671 ± 0.0143 | 0.272 # | −0.0018 ± 0.0065 |
| 14-HDHA | 0.1165 ± 0.0638 | 0.1098 ± 0.0627 | 0.308 # | 0.0067 ± 0.0218 |
| 16-HDHA | 0.0589 ± 0.0142 | 0.0610 ± 0.0122 | 0.389 | −0.0022 ± 0.0083 |
| 17-HDHA | 0.1191 ± 0.0301 | 0.1196 ± 0.0325 | 0.924 | −0.0005 ± 0.0174 |
| 20-HDHA | 0.2074 ± 0.0539 | 0.2079 ± 0.0489 | 0.347 # | −0.0004 ± 0.0370 |
| 5-HEPE | 0.1032 ± 0.0315 | 0.0962 ± 0.0336 | 0.171 | 0.0070 ± 0.0166 |
| 8-HEPE | 0.0352 ± 0.0045 | 0.0327 ± 0.0051 | 0.128 | 0.0025 ± 0.0053 |
| 9-HEPE | 0.0756 ± 0.0137 | 0.0703 ± 0.0095 | 0.155 | 0.0053 ± 0.0121 |
| 11-HEPE | 0.0847 ± 0.0025 | 0.0856 ± 0.0035 | 0.875 # | −0.0008 ± 0.0045 |
| 12-HEPE | 0.1595 ± 0.0220 | 0.1540 ± 0.0228 | 0.136 # | 0.0055 ± 0.0158 |
| 15-HEPE | 0.1078 ± 0.0123 | 0.1036 ± 0.0105 | 0.084 # | 0.0042 ± 0.0085 |
| 18-HEPE | 0.1779 ± 0.0413 | 0.1596 ± 0.0278 | 0.07 # | 0.0183 ± 0.0316 |
| 9-HODE | 8.5190 ± 13.8940 | 8.3464 ± 12.8721 | 0.347 # | 0.1726 ± 1.8733 |
| 13-HODE | 4.3069 ± 3.0614 | 4.4488 ± 2.9851 | 0.53 # | −0.1419 ± 0.6334 |
| CYP ω/(ω−1) metabolites | ||||
| 16-HETE | 0.0626 ± 0.0120 | 0.0631 ± 0.0114 | 0.772 | −0.0006 ± 0.0069 |
| 17-HETE | 0.0242 ± 0.0028 | 0.0240 ± 0.0029 | 0.713 | 0.0002 ± 0.0018 |
| 18-HETE | 0.0456 ± 0.0082 | 0.0451 ± 0.0072 | 0.684 | 0.0005 ± 0.0044 |
| 19-HETE | 0.0387 ± 0.0291 | 0.0392 ± 0.0269 | 0.638 # | −0.0005 ± 0.0216 |
| 20-HETE | 0.1457 ± 0.1239 | 0.0709 ± 0.0885 | 0.084 # | 0.0747 ± 0.1464 |
| 22-HDHA | 0.0843 ± 0.0662 | 0.0754 ± 0.0632 | 0.177 | 0.0089 ± 0.0213 |
| 20-HEPE | 0.0900 ± 0.0271 | 0.0856 ± 0.0284 | 0.638 # | 0.0045 ± 0.0171 |
Notes: A, arterial blood; V, venous blood; A-V difference, arteriovenous difference.