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. 2021 Dec 27;12(1):20. doi: 10.3390/metabo12010020

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Figure A1 — Effects of cold or heat exposure on α-diversity and the relative abundance of microbes at the genus level. (A) α-diversity (Simpson). (B) Changes in gut microbiota at the genus level due to cold exposure. (C) Changes in gut microbiota at the genus level due to heat exposure, (D) Changes in gut microbiota at the genus level due to the timing of mice exposed to 22 or 7 °C for 3 h a day for 10 days. Data are represented as mean ± SEM (n = 7–12). * p < 0.05 *** p < 0.001 evaluated using two-way ANOVA with Sidak’s post hoc analysis.

Figure A1 — Effects of cold or heat exposure on α-diversity and the relative abundance of microbes at the genus level. (A) α-diversity (Simpson). (B) Changes in gut microbiota at the genus level due to cold exposure. (C) Changes in gut microbiota at the genus level due to heat exposure, (D) Changes in gut microbiota at the genus level due to the timing of mice exposed to 22 or 7 °C for 3 h a day for 10 days. Data are represented as mean ± SEM (n = 7–12). * p < 0.05 *** p < 0.001 evaluated using two-way ANOVA with Sidak’s post hoc analysis.