Depression among caregivers of patients with dementia: Associative factors and management approaches

Abstract

As elderly people increasingly come to represent a higher proportion of the world’s population, various forms of dementia are becoming a significant chronic disease burden. The World Health Organization emphasizes dementia care as a public health priority and calls for more support for family caregivers who commonly play a significant, central role in dementia care. Taking care of someone with dementia is a long-term responsibility that can be stressful and may lead to depression among family caregivers. Depression and related behavioral and cognitive changes among caregivers could in turn affect the status and prognosis of the dementia patient. This review article explores depression in dementia caregivers and summarizes proposed mechanisms, associated factors, management and research findings, and proposes future research directions.

Core Tip: The prevalence of depression among caregivers of patients with dementia is higher than that of the general population. The cause of depression in caregivers is complicated and thought to be related to the patients, caregivers and cultural backgrounds. Multifaceted treatment for depression is regarded as the current mainstream clinical intervention. In some areas, supplementation with smart technology for interventions to alleviate the burden and depression of caregivers could be considered. There are also some ideas and directions for future research included in the conclusion section of this review.

INTRODUCTION

Depression is a common and serious health condition that is different from usual mood fluctuations and short-lived emotional responses to challenges in everyday life. It can cause the affected person to suffer greatly and function poorly at work, at school and within the family. According to the World Health Organization, over 264 million people globally suffer from major depressive disorder, which is one of the leading causes of disability worldwide[1]. The prevalence of depression among dementia caregivers is even higher than that of the general population[2]. Because patients with dementia suffer from impairment in cognitive functioning and activities of daily living (bathing, eating, etc.), the caregiver's quality of care to his or her patient or family member is central, and the caregiver is usually with the patient for several hours per day (or resides in the same house). Many studies have shown that the behavioral and psychological symptoms of dementia (BPSD) mutually affect the caregiver’s skills and are also reflexively influenced by the caregiver, so the caregiver's own physical and mental health is extremely important. The topics of depression and the burden of caregivers of dementia patients are popular in clinical research. One of the significant reasons is that interventions for caregiver burden and depression are still a great challenge and an unmet need in clinical practice.

Depression can cause a variety of psychological and physical problems and raise the risk of caregiver suicide[2]. It compromises caregivers’ physical health[3], reduces caregivers’ quality of life[4], and has been shown to cause caregivers to place patients with dementia in an institutional care facility more rapidly[5,6]. Depression in caregivers can also influence dementia patients’ cognitive status and has been associated with more rapid cognitive decline in the dementia patients studied[7].

Caregiver depression is producing a growing impact on existing medical care and insurance systems. Guterman et al[8] suggest that caregiver depression shows a significant association with increased emergency department use. They report that medical systems should specifically address patient- and caregiver-centered dementia care and suggest that improved health outcomes and lower costs for this high-risk population could be achieved.

Many studies have investigated the factors associated with dementia caregiver depression and explored various interventions to address it. The work presented in this review falls into several categories, including prevalence, mechanism, associated factors, management, and research trends of depression in caregivers of patients with dementia.

DEFINITION FOR BURDEN AND DEPRESSION IN CAREGIVERS

The author defined a family caregiver as an adult who directly provides observation, encouragement, assistance, or care that substitutes for a patient’s efforts related to the activities of elderly patients with dementia. Such activities may include assisting the dementia patient to complete housework cleaning or maintenance, managing economic affairs, facilitating and supervising activities outside the home, and the broad supervision and management of safety, legal, and medically related matters.

Caregiver burden

The author can summarize 4 characteristics on the formation and the source of caregiver burden: (1) Direct care work, assistance in daily activities for patients and implementation of medical care; (2) The gap between the caregiver’s expectations and the reality; (3) Breaking the personal routine of the caregiver; and (4) The feelings of taking on the responsibility of the caregiving role.

The caregiver burden has subjective and objective dimensions. The subjective burden refers to the stress and anxiety that the caregiver feels about his or her own situation and the feeling of being manipulated by the care recipient. Objective distress refers to the interference and change of the caregiver’s life habits and household caused by care work[9]. In addition to the above concepts, in clinical outpatient services, caregivers often ask for help and have distress due to the BPSD[10,11].

Caregiver depression

Depression (melancholia) is an emotional response to chronic frustration and disappointment. In psychopathology, it is an affective and emotional disorder[12]. The etiologies for melancholia can be divided into reactive or endogenous types. In general, the mildest form of depressive mood is difficult to distinguish from the experience of disappointment and loss. It is a common, recurrent, and impairing condition that can lead to future suicide attempts, interpersonal problems, unemployment, and psychosocial dysfunctions.

Approximately 80% of dementia patients are being cared for by their families in the community. It was found that patients spent an average of 6.5 years being cared for at home before they were sent to a nursing institution[13]. It takes an average of 4 to 8 h a day to care for elderly individuals with dementia. Fuh et al[14] reported that 56.6% of dementia caregivers care for patients for more than 8 h a day. In the early stage of dementia, family members assist patients with higher and more complex daily life functions, such as assistance in dealing with money or with medication problems. However, as the patient's disease progresses, part of the caregiver's care gradually changes to assisting with self-care, such as bathing, dressing, and eating. The safety of the patient becomes the focus, and the problem of urine or stool incontinence gradually develops. At the same time, the caregiver must also deal with the patient's behavioral disturbances. In the process of caring, caregivers have to face the gradual disappearance and changes of the personality of his or her loved one, and witness the process of degeneration, suffering, distress and facing death. In addition to the direct distress of caring for patients, caregivers also deal with family conflicts, financial problems, and employment problems and adapt themselves to the role of caregiving. Furthermore, family caregivers also play a role in the medical care process of patients, including providing the patient's illness history, describing symptoms, and assisting in medical care[13].

EPIDEMIOLOGY OF CAREGIVER DEPRESSION

Many studies have investigated the quality of life of dementia caregivers and found that they experienced high levels of grief, ambivalence, and other psychological ailments[15]. Major depressive symptomatology was most common, reported by more than 50% of caregivers[16,17]. A meta-analysis study revealed that depression occurs in at least 1 in 3 caregivers of persons with dementia[18,19]. Some previous studies have also reported high rates of caregiver depression, approximately 30%–83%[20].

CLINICAL MECHANISMS OF DEPRESSION IN CAREGIVERS OF DEMENTIA PATIENTS

High prevalence rates of caregiver depression may be explained by several factors. Many mechanisms and models have been developed and tested, and the evolution in understanding depression in those who provide care to family members with dementia is introduced in this section.

Stress process model

The stress process model[21] proposes that caregiver demographics (such as age, sex, employment status, and relationship to the patient) are associated with and actively affect each part of the stress process and types of stress, including subjective stressors, objective stressors, the perception of those stressors, and outcomes such as caregiver burden and depression.

The stress process model assumes that various factors influence stress and coping reactions. Some factors are naturally protective bodily resources that decrease the negative effects of stress. Other associated factors may increase the effects of stress and render the individual more vulnerable to stress. The model suggests that caregiver outcomes are often influenced by subjective and objective stressors, role strains, and psychological strains and are balanced with mediating influences such as coping strategies and social support resources such as family, friends, and other social groups. Other caregiver distress studies identified similar variables present in the stress process model[22]. Caregivers’ mental health outcomes depend not only on objective factors such as the BPSD and number of caregiving hours worked, but also on the caregivers’ subjective appraisals of the individuals with dementia or the accompanying situations[23]. Many caregivers misunderstand that problematic behaviors are under dementia patients’ control. Caregivers making this assumption are more likely to be depressed than those who attribute the BPSD to the disease itself and accept them[23]. On the other hand, caregivers with a sense of purpose, more closeness with the patients, and higher competencies may more easily find positive rewards in this challenging situation[24,25]. Previous studies have indicated that caregiver outcomes, including a sense of self-efficacy in controlling upsetting thoughts about the patient, rather than mechanistically dealing with problematic behaviors or obtaining respite, are highly associated with improved caregiver outcomes[26-29].

Core stress and coping model

Previous studies[30] suggest a common core model for explaining the formation of caregiver distress. In this core model, BPSD are seen as basic stressors for informal caregivers, the caregivers’ personal perceptions of burden as key mediators are incorporated, and it is suggested that higher levels of caregiver burden are positively associated with worse caregiver outcomes.

Sociocultural stress and coping model

Aranda and Knight[31] suggest that culture and ethnicity play important roles in the stress and coping processes of caregivers to elderly individuals. Cultural and ethnic factors may even be associated with specific health disorders and disabilities and explain variations in caregivers’ appraisals of potential stressors. Knight and Sayegh[32] suggest a revised model (Figure 1) that takes cultural values into more robust consideration. They suggest that familism as a cultural value adds multidimensional effects and that values regarding social or familial obligations show more influence than family solidarity. Knight and Sayegh[32] further point out that the effects of cultural values and ethnicity on stress and coping processes are found to relate more to social support and coping styles than to caregiver burden. In summary, cultural values are, at best, indirectly related to the mental health of caregivers, which in turn affects the social and family support of dementia caregivers and further affects the way they respond to dementia patient(s) in their care. The authors suggest that these factors are at least indirectly associated with the mental health of caregivers.

Figure 1.

The sociocultural stress and coping model is based on the core stress and coping model and further takes cultural values into consideration.

Systemic family framework model

The psychological and dynamic dimensions within a family are thought to affect caregiver stress perceptions and coping processes. Acceptance of aversive experiences and a commitment to personal values by the caregiver are proven to be associated with challenges and experiences, including sadness and grief. Although there is usually one member of the family that assumes most caregiving responsibility, the caregiving process impacts the whole family.

Mitrani et al[33] applied structural family theory[34] in studying the role of family functioning in caregiver stress and coping processes. They indicated that family functioning partially mediates the relationship between objective burden and caregiver distress in the stress process model (Figure 2). Mitrani et al[33] suggested that caregiver distress appraisal may be mitigated by any intervention that is best targeted at correcting problematic family interactions and preserving protective family patterns. Family interventions may enhance the participation of dementia patients in family activities, resolution of disagreements, and expressions of emotionality and further decrease expressed negative responses to the patient.

Figure 2.

Systemic family framework model is based on the stress process model and the family functioning is taken into consideration.

Activity restriction model

The Activity Restriction Model[35] suggests that the stresses of caregiving discourage one’s ability to engage in social and recreational activities, and this restriction is expected to contribute to depression. Mausbach et al[36] examined the activity restriction model in the context of dementia caregiver research. Their results suggest that activity restriction significantly mediated the relationship of the caregiving role and depression. On the other hand, they also found that depression acts as a key mediating factor of the caregiving role and activity restrictions. These findings support the use of social and recreational activities of dementia caregivers as opportunities for useful depression-improving behavioral interventions. Moreover, the caregiver’s participation in pleasurable activities (i.e., behavioral activation) could be promoted with behavioral and cognitive-behavioral approaches[37]. These results raise the importance and application of the activity restriction model in explaining and treating caregiver depression.

Suffering-compassion model

Previous studies suggest that caregivers’ perceived suffering of the dementia patients was significantly associated with caregiver depression[38]. The Suffering-Compassion Model demonstrates the relations among the dementia patient’s suffering, and the caregiver’s perceived suffering, intrusive thoughts, and compassion. The contribution of caregivers’ perceived suffering to caregiver depression is, however, mediated by their own personal intrusive thoughts. At the same time, caregiver compassion appears to moderate the relations of the caregiver’s perceived suffering and intrusive thoughts. If the caregiver had higher compassion, he or she was more likely to experience greater intrusive thoughts. It should be noted that the physical suffering of dementia patients may be more easily recognized than their psychological suffering[39]. This could therefore cyclically mediate caregiver perception, reaction, emotion, etc.

In summary, the author merged the above 6 common models for explaining caregiver depression, as shown in Figure 3.

Figure 3.

A conceptual model includes the factors related to the caregiver depression. The figure is based on the stress process model and combined with core stress and coping model, sociocultural stress and coping model, systemic family framework model, activity restriction model, and suffering-compassion model.

FACTORS ASSOCIATED WITH CAREGIVER DEPRESSION

It is important to explore all factors that may be relevant to the development of dementia caregiver depression. By understanding the relevant factors, treatment may be designed to improve caregivers’ mental health.

As dementia diseases progress, an individual’s forethought, planning, organizing, and execution of instrumental and basic activities of daily living (ADL) deteriorate and ultimately require oversight, assistance, and then performance on behalf of the patient. Without caregiver assistance, a large proportion of patients with dementia would need nursing home care earlier in the disease process, and the costs of long-term care would increase. Depression is one of the most important issues for caregivers because it is related to poor quality of life, functional decline, and even mortality. Caregiver depression is thought to be a consequence of care due to a complex interplay of factors that comprises dimensions of the patient, caregiver, and cultural background.

Characteristics of patients with dementia

Previous studies associated caregiver depression with being younger, having White or Hispanic ethnicity (compared to black ethnicity), having a lower educational level, and caring for a patient with ADL dependence[40,41], and behavioral disturbances[41,42]. There is significant evidence that BPSD influence depression in caregivers and may be more influential than the severity of cognitive deficits seen or perceived in the patient[43,44]. Different dementia types are also associated with caregiver depression. Liu et al[45] reported that the severity of patients’ BPSD and caregivers’ perceived stress contributed to the increased caregiver burden. Caregivers for patients with frontotemporal lobar degeneration and dementia with Lewy bodies are likely to have more caregiver burdens than those who care for patients with Alzheimer’s disease.

Apart from cognitive and functional impairment, BPSD affect a large proportion of patients with dementia at some point in their disease course. Behavioral disturbances are highly challenging for patients with dementia, their caregivers, and their physicians, as some BPSD are difficult to manage and associated with a greater caregiver burden, higher risk for nursing home placement, prolonged hospitalization, and reduced quality of life. Huang et al[46] suggested that agitation, aggression, anxiety, nighttime behavior disturbances, irritability, and hallucinations are the five leading BPSD that are significantly related to caregiver depression. Choi et al[47] suggested that different BPSD clusters have a differential impact on caregivers’ mental health. Care providers should first distinguish between rejection of care, aggression, and agitation in patients with dementia and then manage those problematic behaviors to decrease the risk of caregiver depression.

Some studies have found anosognosia in patients with dementia to be related to caregiver burden and depression[48-50]. Anosognosia is characterized by the phenomenon of obvious unawareness, misinterpretation, or total denial of an illness. It is a common symptom of dementia[51]. One explanation is that a patient’s higher level of anosognosia results in a higher burden and depression of the caregiver. Anosognosia would increase caregivers’ social isolation and tension related to obtaining and receiving patient care[50]. Another possible explanation could be that the depression of the caregiver may distort the perceived health status of the dementia patient and possibly cause a more negative assessment of caregiver-rated dementia problems[52].

Other than the patients’ demographics, the subjective feelings of the dementia patients may also be an important topic to be studied, such as the patient’s sensation of suffering. In a longitudinal analysis[53], increases in patients’ suffering were associated with higher caregiver depression. Several studies suggest that measurable manifestations of suffering comprise (1) Physical symptoms such as chronic or acute pain, nausea, and dyspnea; (2) Psychological symptoms such as depressive symptomatology and anxiety; and (3) Spiritual well-being including inner harmony, meaning of life, and the extent to which people find comfort and strength in religious beliefs[54-56].

Characteristics of the caregivers

For dementia caregivers, factors associated with depression risk include having a low income, spending more hours caregiving (40 to 79 h/wk compared to less than 40 h/wk)[40], being female[41], having a spousal relationship[40,57], living with the patient[41,44,58], having poorer health status[44,58], and having a higher caregiver distress sensation[44,58,59]. It has been reported that approximately 80% of caregivers have some form of sleep disturbance. Poor sleep is independently associated with greater depressive symptoms[60].

Robinowitz et al[61] suggested that self-efficacy may be an important factor for recognizing caregiver depression risk. Measurements of self-efficacy in caregivers for dealing with memory decline and behavioral disturbances may be valuable to providers who may care for either or both dementia patients and caregivers. Caregiver self-efficacy relates to their conviction about his or her adaptive ability and skills to manage caregiving problems that may arise. Greater self-efficacy has been associated with better psychological and physical health outcomes in dementia caregivers, including decreased depression and anxiety[62].

It has also been suggested that social support and perceived caregiving competency are significant protective factors for caregiver depression[47].

The commitment to the caregiving role, leisure, and work was associated with the formation of guilt feelings. A higher commitment to the caregiving role has been reported to contribute to lower levels of guilt[63]. Higher levels of guilty feelings are related to lower levels of commitment to the caregiving role and to leisure and higher commitment to work. Feelings of guilt may have resulted in caregivers’ distress and depression[64].

Impact of cultural issues and values

In some regions and cultures around the globe, symptoms of dementia may be regarded as normal aging or even as a consequence of previous wrongdoing. It has also been reported that some South Asian regions tend to consider dementia an outcome of family conflict or impaired family support. On the other hand, African Americans, due in part to religious beliefs, are prone to rely more on prayer and reconstruction of difficult circumstances during challenging times. Dementia is also thought to be influenced by negative spiritual forces. Cultural factors may influence the conceptualization and help-seeking behaviors of patients with dementia and the caregivers that control their access to care. Indeed, cultural factors affect caregiver responses to the cognitive and noncognitive symptoms of dementia and the consequences of adherence or nonadherence to treatment recommendations[65].

Understanding caregiver stress has become an emerging, relevant cultural value[66]. Based on the sociocultural stress and coping model[32], Losada et al[66] explained the association between cultural values and caregiving distress. Traditional beliefs about family obligations, such as the values systems of Asian and Latino/Hispanic regions, may result in psychological strain from a greater than average emphasis on the caregiving role and the encouragement to overlook one’s own needs and feelings. When caregivers feel stress about performing duties and their personal needs are ignored, avoidant coping styles may therefore arise. Avoidant coping strategies may be the mediating factor between familial obligations and cultural values toward caregiver depression[67].

Youn et al[68] suggested that Korean and Korean American caregivers had higher levels of familism and burden than white American caregivers. It is indicated that first-generation employed caregivers appear to have less flexibility and accommodations in their work environments and are more likely to leave their positions when performing caregiving roles than second-generation caregivers. Challenges in utilizing health care systems and language barriers are also higher within the groups of first-generation caregivers[69].

Factors associated with higher rates of dementia caregiver depression, as seen in the literature review, are listed in Table 1.

Table 1.

Factors associated with increased depression in caregivers of patients with dementia in the literature

Dimension	Less modifiable factors	More modifiable factors
Patient	Younger age, white and Hispanic ethnicity, less educational level, type of dementia (frontotemporal lobar degeneration and dementia with Lewy bodies)	More activities of daily living dependence, behavioral disturbances, higher levels of anosognosia, more physical and psychological suffering
Caregiver	Low income, more hours spent caregiving, female sex, spousal relationship, living with the patient, poorer health status	Higher distress sensations, sleep disturbances, lower self-efficacy, lower levels of commitment to the caregiving role, guilty feelings
Cultural	Familism, family obligation, language barriers	Misunderstandings, coping style, less flexibility and accommodations in their work environments

MANAGEMENT FOR CAREGIVER DEPRESSION

Regarding dementia patients, there are few effective interventions to slow and stop the progression of cognitive impairment. However, there are many interventions designed to treat BPSD and therefore alleviate caregiver burden. Multicomponent nonpharmacological treatments, including caregiver education and support, problem solving training, and assistance in comprehending and managing specific behavioral problems, have been suggested to be effective in treating behavioral disturbances and increasing the quality of life of patients with dementia and their caregivers[70].

Numerous studies have been designed to improve depression in dementia family caregivers. We summarized types of caregiver interventions that have been classified by psychoeducation[71-77], leisure and physical activity[37,78-80], counseling[81-90], cognitive-behavioral approaches[91-94], mindfulness-based interventions[95], and psychological and social support[96-99], as shown in Table 2. We also observed and highlighted interventions utilizing telephone and technologies to deliver nonface-to-face management below.

Table 2.

Types of intervention for dementia caregiver depression in the studies

Type of intervention	Content of program
Psychoeducation	Information about dementia and the different stages of dementia severity[71-73], understanding and managing behavioral problems[71,73-76], problem-solving techniques[73], coping strategies for emotional problems[73-75], communication skills[71,73-75], crisis management[73], resource information[73], targeting pain and distress (mood problems, lack of engagement in activities)[74,75,77]
Leisure and physical activity	Education on how to monitor time spent in leisure activities[78,79], identification of enjoyable leisure activities[78,79], prioritizing activities[79], scheduling/participating in leisure activities[79], fostering physical activity[78], individualized goal setting[78], behavioral modification skill training, behavioral activation[37,80], increasing pleasant activities[37,79]
Counseling	Care consultation[81-90], managing dementia symptoms[81,82,84,85,87,88], accessing community support services[81,82,86], telephone-based use of logbooks[83], information about dementia and legal issues and resources for social support[83,86]
Cognitive behavioral approaches	Cognitive reappraisal[91], controlling upsetting thoughts[27], enhancing self-efficacy[27,28], cognitive restructuring[92], assertive skills[92], relaxation[92], acceptance of aversive internal events and circumstances[92], choosing meaningful courses of action[92], telephone-based identification and expression of painful thoughts and emotions[93], managing painful emotions[93], accepting thoughts and emotions[93], redefinition of the relationship[92], reactivation of resources[93], adaptation to bereavement[93,94]
Mindfulness-based interventions	A range of practices with a focus on stress reduction, such as gentle mindful movement (awareness of the body), a body scan (to nurture awareness of the body region by region), and meditation (awareness of the breath)[95]
Psychological and social support	Providing information on formal social support[96,97], mutual sharing of emotions[96-98], creating an appropriate social network and home environment for the caregiver[96], support group participation[96], family role and strength rebuilding[99]

Various interventions and key clinical content elements identified in the literature review are listed below in Table 2.

Psychoeducation

In this intervention, caregivers are educated on suitable skills to deal with caregiving requirements and stress using structured content and are often performed by small groups, including time for practice. The topics in these sessions usually comprise knowledge of dementia, learning to reserve time for self, enhancement of communication and interaction with family members, skills for managing BPSD, and related community services. More specialized topics, such as emotional management, thought and behavioral modification, and pleasant activity scheduling, may also be involved in some studies.

Leisure and physical activity

Daily pleasant experiences can create balance between “self-life” and caring for patients and help caregivers to maintain positive points of view while serving in the caregiving role. Leisure or physical activities may also serve to transform the caregivers’ negative experiences[37]. It is challenging to incorporate activities in the daily lives of caregivers for dementia patients because of their heavy workloads. Moreover, stressed individuals may diminish the skills to engage in positive interactions. The behavioral theory of depression interprets depression as a result of a series of negative reinforcements. Multiple factors create a downward spiral toward the further disruption of a healthy lifestyle and its biological rhythms and social activities, resulting in more severe depressive symptoms.

Counseling

Individual and family counseling is provided by trained providers to help caregivers manage stress and crises. This intervention is performed face to face or through telephone calls.

Psychotherapy and cognitive behavioral approaches

Psychotherapy and cognitive behavioral approaches are performed by trained health care providers to help caregivers manage stress and to treat distress and depression. These interventions are often used for caregivers with clinical depression or other significant mental health problems. They can be performed in individual or group circumstances.

Mindfulness-based interventions

In this treatment model, caregivers are trained in mindfulness and meditation strategies with the basic purpose of concentrating on the present experience nonjudgmentally. Thoughts, emotions, and behaviors are observed without being judged as good or bad with a final aim of relieving suffering. Mindfulness-based interventions are based on acceptance, receptiveness of the current situation, and establishing a balanced coexistence with personal feelings and thoughts, instead of attempting change from the beginning. Mindfulness-based stress reduction is a widely used program that involves practices with a focus on stress reduction, including gentle mindful movement (awareness of the body), a body scan (to foster awareness of the body), and meditation (awareness of the breath)[100]. Dementia not only affects the person who suffers from it but also has an impact on the patients’ caregivers. Caregivers of dementia patients are groups that experience mindfulness problems[101] and symptoms of stress and depression.

Psychological and social support

The support group is characterized by a type of mutual helping that comprises a group of people to share experiences and deal with common problems. Studies have shown that support groups can be valuable resources to the families of dementia patients, and include care information and psychological support[99]. Several studies show that caregiver support groups are able to help individuals relieve the distress of caregiving and decrease depressive symptoms[102].

We divided factors associated with caregiver depression into three dimensions: patient, caregiver, and cultural background according to the literature and matched them with the treatment plan for each factor. The appropriate treatment content corresponding to each factor is listed for reference in Table 3. However, this table needs more clinical research for validation.

Table 3.

Interventions and modifications for caregiver depression in reviewed literature, classified and matched according to the associated factors and dimensions

Patient with dementia
Address physical care domain
	Psychoeducation
	Counseling
	Environmental modification
	Access to community resources
	Relief pain
Address psychological domain
	Psychoeducation
	Cognitive Behavioral approaches
	Strategies to treat and compensate cognitive deficits
	Reality and insight enhancements
Address behavioral and psychological symptoms
	Psychoeducation
	Counseling
	Pharmacological treatments
Caregiver
Address distress sensation
	Leisure and physical activity
	Counseling
	Mindfulness-Based Interventions
	Psychological and social support
Address self-efficacy
	Counseling
	Cognitive Behavioral approaches
	Communication skills
	Behavioral management skills
	Problem-solving techniques
	Crisis management
	Training on nursing care
Address commitment to caregiving role
	Counseling
	Psychological and social support
Address guilty feelings
	Leisure and physical activity
	Counseling
	Cognitive Behavioral approaches
	Psychological and social support
Address sleep problems
	Leisure and physical activity
	Cognitive Behavioral approaches
	Mindfulness-Based Interventions
Address coping strategies
	Psychoeducation
	Leisure and physical activity
	Counseling
	Psychological and social support
	Coping with loss and grief
Address accommodations in work environment
	Counseling
	Psychological and social support

Key factors (listed in Table 1) considered include: (1) For patients: Activities of daily living dependence, behavioral disturbances, higher levels of anosognosia, physical, and psychological suffering; (2) For caregivers: Higher caregiver distress sensations, sleep disturbances, lower self-efficacy, lower levels of commitment to the caregiving role, guilty feelings; and (3) For cultural background: Coping style, less flexibility, and accommodations in their work environments.

DELIVERY OF TREATMENT FOR CAREGIVER DEPRESSION

Because of dementia caregiving duties or conflicts with other schedules, face-to-face interventions for caregivers are not practical in certain situations. Family caregivers may also have difficulties leaving the patient to participate in intervention activities in certain places. Furthermore, interventions for caregivers are possibly not available or difficult to participate in many communities around the world, such as rural or underdeveloped communities. Nonface-to-face interventions may also be practical in the current clinical environment with the coronavirus disease 2019 pandemic.

Telephone-based intervention

As dementia progresses, caregivers may become isolated and need a prolonged period of time to meet caregiving demands. This condition can make it difficult for them to leave their homes to seek support and resources through face-to-face interventions. To overcome these barriers, telephone-based interventions targeted to increase accessibility for caregivers are recommended. Telephone-based interventions have been demonstrated to promote the physical and mental health of caregivers[86,87]. Furthermore, telephone-based intervention is an alternative for caregivers for whom certain services are not available locally[89].

Telephone coaching also has the advantage of offering individualized recommendations for the caregiver. This is not always possible in a group setting, such as a large educational group. In some crisis situations, caregivers wanted to meet face-to-face with their instructors for suggestions. Interventions combining telephone and video have been introduced and performed[103].

Technology-driven interventions

Interventions for depression using eHealth or Connected Health (CH) largely employ information and communication technologies for caregivers. These evaluations, interventions, and treatments are performed via the internet[104]. For instance, these interventions can be provided in the form of an online course on the computer. Healthcare providers can also utilize smartphone or tablet applications designed to provide newer information and psychological support from peers as well as professionals. The care model is assisted by technology, and all the associated disciplines involved in patient care can be communicated through a health portal that offers beneficial information between formal and informal caregivers. Additionally, some programs for technology-driven interventions use technologies such as body-worn and monitoring devices. Health care professionals can help informal caregivers monitor dementia patients’ health status using these devices. The devices can provide an event alert (such as a fall or other emergency event) and facilitate communication. Technology-driven models could provide a handy and lower cost intervention compared to traditional home care, supply a family caregiver with social interaction and emotional support and facilitate information exchange with other caregivers and professionals. It could also ameliorate the decision-making process for matters about patient care[105]. The literature also suggests that dementia caregiver burden and stress could be reduced through technology-driven interventions[106]. At the same time, the self-efficacy and quality of life of caregivers will be improved by this type of intervention[105].

A study performed in Ireland[107,108] used a Connected Health Sustaining Home Stay Model for caring for patients with dementia and their caregivers. The purpose of the study was to (1) Assess the effectiveness of the platform in supporting caregivers at home; (2) Study the potential improvement of patients with dementia and their family caregivers’ mental and physical health; and (3) Investigate the platform’s usability and user experience. Another example is the system named the A Technology Platform for the Assisted Living of Dementia Elderly Individuals and their Carers[109]. It is a digital platform designed to offer support to the informal caregiver.

Case management

Patient-centered care planning is essential for case management. It includes identification and outreach, comprehensive individualized assessments, care planning, care coordination, service provisions, monitoring, evaluation and fulfilling individualized needs[110].

Due to the complexity of the symptoms of dementia, the model using a multidisciplinary approach and integrated working is beneficial in care for dementia patients. Case managers, nurses, psychiatrists, pharmacists, psychologists, occupational therapists, and social workers are all involved in decision making and supporting the caregivers living with people with dementia[111].

CONCLUSION

Overall, the prevalence of depression among dementia caregivers is higher than that seen in the general population. A structured way to study and verify associated factors and etiologies for caregivers’ depression is based on the stress coping model, which may then be expanded by adding relevant important variables. The activity restriction model in the mechanism of caregiver depression also provides an important theoretical basis for interventions and management, such as behavioral activation, leisure, and physical activities. There are many interventions used to manage caregiver depression in the literature, but after further reviewing the intervention methods, it was found that most recommended treatment plans incorporated multicomponent interventions.

The following points provide some perspective and a few suggestions to address currently unmet gaps in treatment adequacy for depression in caregivers of patients with dementia.

Understanding the clinical mechanisms of depression requires investigating psychosocial, physiological, and biological contributions. Is there a difference between depression in caregivers of dementia patients and the general population in imaging studies or in brain neuroendocrine studies? These questions need further exploration.

Most of the current research utilized psychosocial approaches. What should be further studied is whether there will be a meaningful improvement if the caregiver’s depression is also given pharmacological treatment such as antidepressants. Is there a difference in antidepressant efficacy between dementia caregivers and the general population? For individual depression symptoms, are there differences in the treatment response of these two groups?

Additionally, many current clinical studies available for review were based on cross-sectional research designs. The behavioral symptoms and daily life functions of dementia deteriorate over time. More long-term follow-up studies are needed to track whether the depressive symptoms of caregivers also change over time.

Dementia is known to occur in many different forms, each having different symptoms and disease courses. For instance, patients with vascular dementia have more obvious physical disabilities and often experience stepwise cognitive declines following each clinically diagnosed stroke event. Cognitive functioning in those with Alzheimer's disease degrades slowly, from instrumental ADL to the most basic ADL. Different types of dementia may very well have different impacts on the moods and daily lives of their caregivers.

Many clinical studies assessed the depression of caregivers by using self-rated scales or scales asking about subjective feelings as the main outcome. One such instrument is the Center for Epidemiologic Studies Depression Scale[112], whose reliability and validity have been proven. Maintaining reliability and validity is best assured by objective evaluation by trained researchers. Two scales also recommended as appropriate evaluation tools are the Hamilton Depression Rating Scale[113] and the Montgomery–Asberg Depression Rating Scale[114].

The clinical problems of patients with dementia are individual and unique. The author believes that the formulation and implementation of individualized treatment plans are an important component of addressing dementia caregiver depression. Therefore, the case management model for people with dementia and their caregivers needs promotion and the opportunity to evolve to meet these populations’ needs.