Dear Editor:
We would like to share ideas on the publication “Subacute thyroiditis after anti-SARS-CoV-2 (Ad5-nCoV) vaccine.1” Rebollar reported a case and mentioned for possible clinical association between thyroid problem and COVID-19 vaccination.1 Thyroid problem might be followed vaccination and the pathogenesis is still inconclusive. Regarding subacute thyroiditis, there are sporadic case reports in COVID-19 vaccine recipients.2, 3 The observed thyroid abnormality might or might not be associated with vaccination. After vaccination, the abnormal thyroid function might occur and it is not related to any immunological abnormality.4 Hyperviscosity might occur after vaccination4 and it can result in an aberrantly thyroid function.5
Authors contribution
SY (50%): (1a) Substantial contributions to study conception and design. (1b) Substantial contributions to acquisition of data. (1c) Substantial contributions to analysis and interpretation of data. (2) Drafting the article or revising it critically for important intellectual content. (3) Final approval of the version of the article to be published.
VW (50%): (1a) Substantial contributions to study conception and design. (1b) Substantial contributions to acquisition of data. (1c) Substantial contributions to analysis and interpretation of data. (2) Drafting the article or revising it critically for important intellectual content. (3) Final approval of the version of the article to be published.
Funding
No funders pertaining to this article.
Conflict of interest
The authors ask for waiving for any charge relating to this correspondence.
References
- 1.Rebollar A.F. Subacute thyroiditis after anti-SARS-CoV-2 (Ad5-nCoV) vaccine. Enferm Infecc Microbiol Clin. 2021;(November) doi: 10.1016/j.eimc.2021.10.015. [online ahead of print] [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Sözen M., Topaloğlu Ö., Çetinarslan B., Selek A., Cantürk Z., Gezer E., et al. COVID-19 mRNA vaccine may trigger subacute thyroiditis. Hum Vaccin Immunother. 2021;10(December):1–6. doi: 10.1080/21645515.2021.2013083. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Jeeyavudeen M.S., Patrick A.W., Gibb F.W., Dover A.R. COVID-19 vaccine-associated subacute thyroiditis: an unusual suspect for de Quervain's thyroiditis. BMJ Case Rep. 2021;14 doi: 10.1136/bcr-2021-246425. e246425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Mungmunpuntipantip R., Viroj Wiwanitkit V. Abnormal thyroid function following COVID-19 vaccination. Indian J Endocrinol Metab. 2021;25:169. doi: 10.4103/ijem.ijem_286_21. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Joob B., Wiwanitkit V. Expected viscosity after COVID-19 vaccination, hyperviscosity and previous COVID-19. Clin Appl Thromb Hemost. 2021;27 doi: 10.1177/10760296211020833. [DOI] [PMC free article] [PubMed] [Google Scholar]