REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Human CD69, BUV395	BD Biosciences	Cat#564364; RRID: AB_2738770
Anti-human CD8, BUV496	BD Biosciences	Cat#612942; RRID: AB_2870223
Anti-Human CD45RA, BUV563	BD Biosciences	Cat#612927; RRID: AB_2870212
Anti-Human CD11c, BUV661	BD Biosciences	Cat#612968; RRID: AB_2870241
Anti-Human CD56, BUV737	BD Biosciences	Cat#612767; RRID: AB_2860005
Anti-Human CD3, BUV805	BD Biosciences	Cat#612896; RRID: AB_2870184
Anti-Human IgD, BV421	Biolegend	Cat#348226; RRID: AB_2561619
Anti-Human CD16, SuperBright436	ThermoFisher	Cat#62-0166-42; RRID: AB_2716985
Anti-Human CD25, eFluor450	ThermoFisher	Cat#48-0257-42; RRID : AB_2574011
Anti-Human CD20, BV480	BD Biosciences	Cat#566132; RRID: AB_2739531
Anti-Human CD127, BV510	Biolegend	Cat#351332; RRID: AB_2562304
Anti-Human HLA-DR, BV570	Biolegend	Cat#307638; RRID: AB_2650882
Anti-Human CD28, BV605	Biolegend	Cat#302968; RRID: AB_2800755
Anti-Human CD38, BV650	Biolegend	Cat#356620; RRID: AB_2566233
Anti-Human CD15, BV711	Biolgend	Cat#323050; RRID: AB_2750192
Anti-Human CD279, BV750	Biolegend	Cat#329966; RRID: AB_2810505
Anti-Human CD206, BV785	Biolegend	Cat#321142; RRID: AB_2734302
Anti-Human CD45, QDOT800	ThermoFisher	Cat#Q10156; RRID: AB_1500477
Anti-Human CXCR5, BB515	BD Biosciences	Cat#564624; RRID: AB_2738871
Anti-Human CD169, AF488	R&D systems	Cat#FAB5197G; RRID: AB_2905550
Anti-Human CD4, Spark Blue 550	Biolegend	Cat#344656; RRID: AB_2819979
Anti-Human CD161, PerCP	Biolegend	Cat#339933;RRID: AB_2563998
Anti-Human CD27, BB700	BD Biosciences	Cat#566449; RRID: AB_2739731
Anti-Human Siglec8, PerCP Cy5.5	Biolegend	Cat#347108; RRID: AB_2629716
Anti-Human CD86, PerCP eFLuor710	ThermoFisher	Cat#46-0869-42; RRID: AB_10596362
Anti-Human CD141, PE	Biolegend	Cat#344104; RRID: AB_2255842
Anti-Human TCRg/d, PEdz594	Biolegend	Cat#331226; RRID: AB_2565534
Anti-Human TCRa/b PE Cy5	Biolegend	Cat#306710; RRID: AB_314648
Anti-Human CD11b, PE Cy7	Biolegend	Cat#301322; RRID: AB_830644
Anti-Human CD123, APC	Biolegend	Cat#306012; RRID: AB_439779
Anti-Human CRTH2, AF647	Biolegend	Cat#350104; RRID: AB_10642025
Anti-Human CD14, Spark NIR	Biolegend	Cat#367150; RRID: AB_2820023
Anti-Human CD1c, APC R700	BD Biosciences	Cat#566614; RRID: AB_2869794
Anti-Human CD103, APC Cy7	Biolegend	Cat#350228; RRID: AB_2734362
Anti-Human CD45, PerCP Cy5.5	ThermoFisher	Cat#45-0459-42; RRID: AB_10717530
Anti-Human Siglec8, AF488	R&D systems	Cat#FAB7975G; RRID: AB_2905535
Anti-Human CD19, BV421	Biolegend	Cat#302234; RRID: AB_11142678
Anti-Human CD4, BV510	Biolegend	Cat#317444; RRID: AB_2561866
Anti-Human CD117, BV605	Biolegend	Cat#313218; RRID: AB_2562025
Anti-Human CD14, BV711	Biolegend	Cat#301838; RRID: AB_2562909
Anti-Human CD16, BV785	Biolegend	Cat#302046; RRID: AB_2563803
Anti-Human CD177, FITC	Biolegend	Cat#315804; RRID: AB_2072603
Anti-Human Siglec8, PE	R&D systems	Cat#FAB7975P; RRID: AB_2905537
Anti-Human CD56, PEdz594	Biolegend	Cat#318348; RRID: AB_2563564
Anti-Human CD3, PE-Cy7	Biolegend	Cat#300420; RRID: AB_439781
Anti-Human CD206, APC	Biolegend	Cat#321110; RRID: AB_571885
Anti-Human FcE, AF700	Biolegend	Cat#334630; RRID: AB_2571902
Chemicals, peptides, and recombinant proteins
LIVE/DEAD Fixable NIR Cell Stain	ThermoFisher	Cat#L34976
LIVE/DEAD Fixable Blue? Cell Stain	ThermoFisher	Cat#L34961
TruStain FcX	Biolegend	Cat#422302
RPMI 1640	Gibco	Cat#21875091
Critical commercial assays
Target 96 Cardiometabolic Assay	Olink	Cat#91802
Target 96 CVD II Assay	Olink	Cat#91202
Target 96 CVD III Assay	Olink	Cat#91203
Target 96 Immune Response Assay	Olink	Cat#91701
Target 96 Inflammation Assay	Olink	Cat#91301
DPP4 ELISA	R&D Systems	Cat#DY1180
Albumin ELISA	Bethyl Laboratories	Cat#E80-129
LDH Assay	Sigma Aldrich	Cat#TOX7
LEGENDplex Human Proinflam. Chemokine Panel 1	Biolegend	Cat#740984
Deposited data
Proteomic data and associated clinical and demographic information	Dryad	https://doi.org/10.5061/dryad.2ngf1vhq3
R code used in analysis of proteomic data	Github/Zenodo	https://doi.org/10.5281/zenodo.5844957
Software and algorithms
Flowjo version 10.7 software	Treestar	https://www.flowjo.com
STRING protein module visualisation	String	https://www.string-db.org
RStudio version 1.2.1335	RStudio	https://www.rstudio.com
R version 3.5	R Foundation for Statistical Computing	https://www.R-project.org