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. 2021 Nov 23;601(7894):617–622. doi: 10.1038/s41586-021-04232-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — The 18 participants who were not enrolled did not meet the inclusion criteria at screening. All 36 enrolled participants received one dose of the CoVac-1 vaccine. Safety oversight to proceed to part II was performed by an independent safety monitoring committee and approved by the Paul Ehrlich Institute and the local Ethics Committee after an interim safety and immunogenicity analysis of study participants included in part I on day 28 after vaccine administration. n, number.