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. 2021 Nov 23;601(7894):617–622. doi: 10.1038/s41586-021-04232-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — T cell responses to HLA class I-restricted SARS-CoV-2 peptides embedded within the CoVac-1 vaccine peptides (matching the HLA allotype of the respective participant) were assessed by (a) tetramer staining and (b) IFNγ ELISPOT assays after in vitro expansion of PBMCs from study participants (part I and II) obtained on day 28 after vaccination. Pie charts display number of samples with (a) specific T cells or (b) IFNγ T cell responses to CoVac-1-embedded peptides (pos, positive; neg, negative; n.a., not assessed). Dots represent frequencies of peptide-specific T cells shown for individual donors with detected T cell responses only. (c) Frequencies of functional CoVac-1‐induced CD4⁺ T cells in study participants prior to vaccination (day 1) and at day 28 following vaccination using intracellular cytokine (IFNγ, TNF, and IL-2) and surface marker staining (CD107a). The right graph displays the proportion of samples revealing difunctional (2), trifunctional (3), or tetrafunctional (4) T cell responses. (a–c) Box plots or combined box-line plots show median with 25^th or 75^th percentiles, and min/max whiskers, two-sided Wilcoxon signed-rank test. no, number; pos, positive.

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