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. 2021 Dec 7;601(7894):623–629. doi: 10.1038/s41586-021-04278-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Box plots showing associations between proliferation (GGI) GSVA scores across ER/HER subtypes. b, Top: Scatter plots showing the distribution of the mitotic and ceramide score components of a taxane response metagene within the HER2- and HER2+ cohorts. Bottom: Box plots showing association of the combined taxane response metagene score within the HER2- and HER2+ cohorts. In a, b, the box bounds the interquartile range divided by the median, with the whiskers extending to a maximum of 1.5 times the interquartile range beyond the box. Outliers are shown as dots. Two-tailed Wilcoxon rank sum tests. Number of cases (n): ER-HER2-: 37, ER+HER2-: 57, HER2+: 55.