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. Author manuscript; available in PMC: 2022 Jan 27.
Published in final edited form as: Immunity. 2020 Nov 17;53(5):908–924. doi: 10.1016/j.immuni.2020.10.015

Figure 3. Effects of early ART administration during acute HIV infection on peripheral and tissue immune responses.

Figure 3.

We are just beginning to understand the effects of early ART on AHI with improved NHP models and cohorts treating at HIV-detection throughout Fiebig Stages I-III. Overall, early ART mitigates peripheral cytokine production and adaptive immune cell dysfunction. Samples from early ART treated individuals in prospective cohorts provide a unique opportunity to explore similarities and differences in cellular response and phenotype across tissue compartments. Whether we can use our understanding of these improved antiviral responses to inform long-term cure strategies or vaccines is still unknown. Abs = antibodies; HPC = hematopoietic precursor cell.