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. 2021 Dec 25;5:38. doi: 10.21037/med-2021-01

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2021 Mediastinum. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Microscopic features of the mediastinal tumor. (A) Low-power magnification of a tumor (Tu) and normal thymus (Th) separated by fibrous capsule (Cap). Three elements could be identified: an organoid component (Org), lymphocytes-poor, epithelial component (L-p) and fatty tissue (F). There was no evidence of invasion outside the capsule. (B) Medium-power magnification of the tumor - organoid component (Org), lymphocyte-poor, epithelial (L-p) component and fatty tissue (F). All elements were covered by a fibrous capsule (Cap). A small rim of compressed normal thymic tissue was visible outside the capsule. (C) The organoid component (Org) reproduced the morphology of the normal thymus and contained light staining, medullary (med) areas with Hassall corpuscles (H) and dark staining, cortical (cor) areas. (D) Normal-looking, mature fat inside the tumor. (E) The lymphocytes-poor component comprised of densely packed epithelial cells with slight atypia (inset). [Hematoxylin and eosin stain, magnification ×5 (A), ×20 (B), ×40 (C,D,E) and ×200 (inset)].