Table 2.

Adjusted Models of Cortisol Values by Palpitations Distress

		Palpitations Distress
		No	Yes
	Model	Estimate (95% CI)	Estimate a (95% CI)	p b
Total AUCc	1	1.00 (ref)	−0.13 (−0.35 to 0.09)	0.26
	2	1.00 (ref)	−0.15 (−0.36 to 0.06)	0.17
	3	1.00 (ref)	−0.15 (−0.37 to 0.07)	0.18
Wake	1	1.00 (ref)	−0.11 (−0.31 to 0.08)	0.25
	2	1.00 (ref)	−0.12 (−0.32 to 0.07)	0.21
	3	1.00 (ref)	−0.08 (−0.27 to 0.12)	0.45
Wake + 30	1	1.00 (ref)	−0.26 (−0.47 to −0.05)	0.02
	2	1.00 (ref)	−0.24 (−0.45 to −0.02)	0.03
	3	1.00 (ref)	−0.25 (−0.45 to −0.04)	0.02
Early afternoon	1	1.00 (ref)	0.18 (−0.07 to 0.44)	0.16
	2	1.00 (ref)	0.17 (−0.07 to 0.41)	0.17
	3	1.00 (ref)	0.15 (−0.11 to 0.41)	0.26
Bedtime	1	1.00 (ref)	0.03 (−0.30 to 0.35)	0.88
	2	1.00 (ref)	0.02 (−0.29 to 0.33)	0.91
	3	1.00 (ref)	0.02 (−0.30 to 0.34)	0.90

^aEstimates, 95% confidence intervals, and

^bp-values from 15 different repeated measure linear regression models (3 models x 5 outcomes) represent the mean log transformed cortisol difference between participants reporting racing heart distress compared with those not reporting it, after adjustment for other factors as described below.

Model 1: Adjusted for day, clinical center

Model 2: Adjusted for factors in Model 1 + age, race, marital status, full-time employment, smoking, menopause status, body mass index, systolic blood pressure, diastolic blood pressure, vasomotor symptoms

Model 3: Adjusted for factors in Models 1 and 2 + medication use, depression (Patient Health Questionnaire-8), stress (Perceived Stress Scale), and insomnia (Insomnia Severity Index)

^cTotal area under the curve is scaled to the median wake to bedtime, 14 hours

AUC = Area under the salivary cortisol concentration versus time curve; CI = Confidence interval; ref = Reference