Modern evidence and future prospects of external body radiation therapy for lung oligometastases of breast cancer

Abstract

After Hellman and Weichselbaum defined “Oligometastasis” in 1995, several local therapies for lung oligometastases including surgical resection and external body radiation therapy were reported that improved local control (LC) and progression-free survival, overall survival, and quality of life. This suggests that oligometastases is a potentially curable state. Modern advances in radiation therapy such as stereotactic body radiation therapy (SBRT) in which high dose coverage of target lesion without exposure of normal organ is possible, and are widely used to treat solitary or a limited number of primary lung cancer and metastases. Several reports showed that SBRT was a useful treatment method for lung oligometastases, and the LC rate of SBRT was 80–90% in 2 years and less invasive than surgical resection. SBRT is a safe and effective especially for small and peripheral lung metastases. However, if the metastatic lesion is big or centrally located, careful treatment is necessary to prevent radiation pneumonitis. After SBRT, it is sometimes difficult to differentiate local recurrence and pulmonary injury, especially in the early phase. However, it is important to detect local recurrence especially in patients who require further local therapy such as surgical resection and re-irradiation or systemic therapy. The diagnosis can be improved by determining the natural course after SBRT and local recurrence with computed tomography imaging and ¹⁸F-fluorodeoxyglucose positron emission tomography, respectively. Moreover, radiation therapy may have both local and systemic effects that are related to the enhancement of immune-response after radiation. Currently, several trials evaluating the benefits of SBRT for oligometastatic breast cancer are underway. However, the adaption of SBRT for lung metastases including other treatment strategies should be carefully discussed by the radiation oncologist and a multi-disciplinary team comprising a breast surgeon, medical oncologist, diagnostic radiologist, and radiation oncologist, among others.

Introduction

The standard treatment strategy for metastatic breast cancer is systemic chemotherapy or hormone therapy that treats both gross lesions and microscopic metastatic lesions which cannot be detected in diagnostic images. However, these strategies cannot eradicate gross metastases, and hence, these are mainly focused on preventing progression and new metastasis and maintain the quality of life (QOL) but do not aim to cure. In 1995, Hellman and Weichselbaum were the first to define the innovative concept of “oligometastases” in which a single or a limited number of metastatic lesions exist that are not systemically widespread (1). Subsequently, oligometastases are widely known because of the modern advancement in both diagnostic methods and less-invasive treatment techniques. Local treatment for oligometastases such as surgical resection, radiofrequency ablation, and external beam radiation therapy (EBRT) are beneficial as they may be able to achieve complete response or “cure” patients such that further systemic therapy can be avoided. Several reports (2-4) showed that local treatment of oligometastases improves not only local control (LC) of metastatic lesions, progression-free survival (PFS), and overall survival (OS); hence, oligometastases are a potentially curable state and should be treated by a multi-disciplinary team including breast surgeon, medical oncologist, diagnostic radiologist, and radiation oncologist, among others (5). EBRT as a local therapy for lung oligometastases was reported to have a good LC rate and was less invasive than surgical resection. Furthermore, in the case of stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC), there were only a few clinically significant changes in the health-related QOL before and after SBRT (6).

In this review article, we discuss the modern evidence and future prospects of EBRT, especially SBRT [or stereotactic ablative radiotherapy (SABR)]. Since the target audience is non-radiation oncologists, we omitted details regarding radiation planning and focused on clinically important aspects such as clinical outcomes, toxicities, follow-up after EBRT, and future prospects of SBRT. We hope that this article will be helpful for oncologists who are considering SBRT or following up patients after SBRT.

Radiation technique and regimens for lung metastases: differences between three-dimensional conformal radiation therapy (3D-CRT) and SBRT

Two kinds of EBRT methods are available for local therapy of lung oligometastases: 3D-CRT and SBRT/SABR. The different characteristics of these therapies are listed in Table 1, and Figure 1 shows the difference in dose contribution between these two methods. The most commonly used method to treat any kind of cancers is 3D-CRT. In this, the megavoltage X-rays are fitted to the tumor shape by multi-leaf collimators which are located at the gantry of linear accelerator and are irradiated from 2–4 directions. However, in 3D-CRT, the irradiated area is shaped as a band or box, and therefore, normal organs around the target lesion are unnecessarily included in the irradiated area, as shown in Figure 1A. To decrease the side effects caused by the unnecessary irradiation of normal organs, the dose per fraction is limited to 1.8–2.0 Gy and irradiation accumulated up to approximately 60 Gy in 30 fractions for 6 weeks.

Table 1. Differences between three-dimensional conformal radiation therapy (3D-CRT) and stereotactic body radiation therapy (SBRT).

Methods of radiation	3D-CRT	SBRT
Dose-per-fraction	1.8–2 Gy/fraction	Several protocols are used worldwide; approximately 7.5–22.5 Gy/fraction (7-11)
Total fractions (treatment duration)	28–33 fractions in 6–7 weeks	Several protocols are used worldwide; approximately, within 1–2 weeks (7-11)
Total dose	60–66 Gy	Several protocols are used worldwide; in Japan, 48 Gy in 4 fractions is most frequently used; followed by 50 Gy in 5 fractions, and 60 Gy in 8 fractions (7); usually, for central lesions, total dose and dose-per-fraction are modified for example 50 Gy in 5 fractions and 56 Gy in 7 fractions, however, several prospective trials are undergoing regarding the treatment of central lesions
Biological effective dose α/β=10 (BED10)	72 Gy for 60 Gy/30 fractions	105.6 Gy for 48 Gy/4 fractions, 100 Gy for 50 Gy/5 fractions; BED10>100 Gy is related with good prognosis (12,13)
Dose contribution	Band or box-shaped irradiation area including target lesion; hence, normal organs around the target are widely included	Almost target fitted irradiation area with minimal margin for the target; hence, decrease dose of normal organ near the target is possible

Figure 1.

The differences in dose distribution between three-dimensional conformal radiation (3D-CRT) (A) and stereotactic body radiation therapy (SBRT) (B) for the same left lung metastasis near the hilum of an esophageal cancer patient. (A) Using 3D-CRT shows a belt-shaped irradiation area including a part of extra-tumoral left lung whereas (B) SBRT can make an almost tumor-shaped dose distribution which enables high dose coverage of tumor lesion and reduction of unnecessary irradiation of normal organs at the same time. (C) The overview of irradiation beams of SBRT.

Modern advantages of radiation techniques such as image-guided radiation therapy and breath-gated radiation enabled the radiation oncologist to minimize the planning target volume (PTV) and irradiate with high accuracy. These techniques minimize the area of unnecessarily irradiated normal organs. In the case of SBRT/SABR, the radiation oncologists can plan a high dose coverage of target lesions and reduce radiation exposure of the area surrounding the target lesions, as shown in Figure 1B. Therefore, radiation oncologists can deliver high radiation doses per fraction to the target lesion within a short period. A high dose per fraction is associated with a shorter treatment period and better improvement in the local tumor control than the conventionally used dose per fraction of 1.8–2 Gy (14). Stereotactic radiation was initially used for intracranial lesions, and after stereotactic irradiation for extracranial lesions using the linear accelerator was reported in 1994–1995 (15,16), SBRT for NSCLC was dynamically widespread. For Stage I NSCLC, the result of SBRT was comparable to that of surgery (17).

To the best of our knowledge, there are no randomized trials for comparing SBRT with 3D-CRT in the treatment of lung metastases. However, randomized trials evaluating SBRT and 3D-CRT in early Stage NSCLC are available. In a randomized phase III trial comparing SBRT and 3D-CRT for NSCLC, no significant difference was observed, SBRT tended to have better disease control (LC) rate and less toxicity than 3D-CRT (18). Therefore, the authors concluded that SBRT should be the standard method because of its short treatment duration and reduced complications (18). Another randomized phase III trial published in 2019 showed that SBRT had significantly better LC and cancer-specific OS (19). According to these reports, SBRT/SABR may be preferred also for the treatment of lung metastases. In Japan, the Japanese insurance system covers SBRT for lung metastases that are 5 cm or smaller in size and with up to three lesions without extrapulmonary metastases.

An international survey on definitive SBRT for oligometastases which was published in 2017 showed that 83% of radiation oncologists began using SBRT since 2005, of which, 99% planned to continue using SBRT and 66% planned to increase the use of SBRT (20). In this survey (20), 59% of radiation oncologists who were not using SBRT for oligometastases were planning to begin SBRT soon. Therefore, to conduct SBRT for oligometastases may become one of the essential skills for radiation oncologists.

Although we did not discuss the planning of SBRT, we want to inform that several dose regimens for SBRT are available according to the site of target lesion (peripheral or central), tumor size, and the distance of normal organs from the target lesions such as chest wall, ribs, heart, esophagus, stomach, and brachial plexus. The national survey in Japan in 2009 showed that the most frequently used SBRT dose schedule for lung metastases was 48 Gy in 4 fractions followed by 50 Gy in 5 fractions and 60 Gy in 8 fractions (7). To determine the appropriate dose per fraction and accumulated total dose, previous reports showed that the biological effective dose α/β=10 (BED₁₀), which was calculated as “total dose” × (1 + “dose per fraction”/10), should be more than 100 Gy to achieve good LC (12,13). In our institution, we mainly used 42–55 Gy in 4 fractions for 100% dose coverage 95% volume of PTV according to JCOG1408, which is undergoing clinical trial for non-operable NSCLC. However, sometimes we modify the dose, for example, 56 Gy in 7 fractions (BED₁₀=100.8) to isocenter as reference point for centrally located lesions. The appropriate dose schedule is determined by radiation oncologists according to the tumor status, patient’s status, skill of the radiation therapist, and radiation equipment available at the institution. Nevertheless, nearly all dose schedules of SBRT for lung metastases are completed within 1–2 weeks.

In conclusion, SBRT may be preferred to 3D-CRT for lung oligometastases since SBRT has better LC, less complication, and shorter treatment interval that 3D-CRT, according to the randomized phase III trials. However, these trials studied early-stage NSCLC and not lung oligometastases.

Treatment outcomes and toxicities of SBRT/SABR for lung oligometastases

Several studies reported the usefulness of SBRT for oligometastases from primary organs, however, only a few articles focused on oligometastatic breast cancer and these articles were summarized in Table 2. One study reported that SBRT for lung/liver oligometastases from breast cancer showed good LC rate: 1-year LC 98%, 2–3 years of LC 90%, complete response 53.2%, partial response 34%, and progressive disease 12.8%. Despite good LC, median PFS (11 months) and median OS (48 months) were not satisfactory (23). No grade 3–4 toxicities according to common terminology criteria for adverse events (CTCAE) were observed (23). Moreover, they showed that disease-free interval (DFI) between the first diagnosis of breast cancer and appearance of metastases was longer than 12 months, and hormone-positive and systemic chemotherapy after SBRT was related to good prognosis (23). Milano et al. (21) evaluated the treatment outcomes for lung/liver/bone/lymph nodes (LN) oligometastases from breast cancer and reported 2-year PFS 44%, 4-year PFS 38%, 2-year LC 89%, and 4-year OS 59%. Moreover, one metastatic lesion, small tumor volume, metastases limited to bone, and stable or regressing lesions prior to SBRT were correlated with a good prognosis. However, other reports in which primary lesion was not limited breast cancer and treatment outcomes were compared between breast cancer and non-breast cancer showed that oligometastatic breast cancer had a tendency for a good prognosis, but it was not significantly different than non-breast cancer (8,24,25).

Table 2. Treatment outcome of SBRT for oligometastatic breast cancer.

Author/year	Number of patients	Target	Outcomes	Toxicities	Prognostic factor
Milano et al. (21)/2009	Curative intent:40 patients with 1–5 metastatic lesions	Total of 85 lesions: lung 19; liver 33; bone 17; LNs 16	Median PFS: 23 months; 2-year PFS: 44%; 4-year PFS: 38%; 4-year LC: 89%; 4-year OS: 59%	No data	Metastasis to only one lesion; small in size; bone only metastasis; stable or regressing with systemic therapy metastases before SBRT
	Palliative intent: 11 patients with more than 6 metastatic lesions; SBRT for only potentially fatal lesions	Total of 23 lesions: lung 6; liver 16; bone 1	Median OS: 13 months (4–24 months); median PFS: 4 months (3–16 months)	No data	No data
Milano et al. (22)/2012	39 patients with 1–5 metastases	Total of 47 sites: lung 11; liver 13; LNs 11; brain 1; bone 11	2-year OS 74%; 2-year freedom from widespread distant metastasis 52%; 2-year LC: 87%; 6-year OS: 47%; 6-year freedom from widespread distant metastasis 36%; 6-year LC 87%	No G4–5	The variables of bone metastases; metastasis to only one site
Scorsetti et al. (23)/2016	33 patients with less than 5 metastases within 5 cm in each size	Total of 35 lesions: lung 7; liver 28	Median PFS 11 months; 1-year LC 98%, 2.3-year LC 90%, CR 53.2%; PR 34%; PD 12.8%; median OS 48 months; 2-year OS 66%	No G3–5; nausea and vomiting G1–2 in 18%; G2 gastritis in one patient; G2 Cough in one patient	DFI >12 months; hormonal receptor-positive; medical therapies after SBRT

SBRT, stereotactic body radiation therapy; PFS, progression-free survival; LC, local control; OS, overall survival; LN, lymph node; CR, complete response; PR, partial response; PD, progressive disease; G, grade.

Although only a few reports on oligometastatic breast cancer are available, a large number of reports on SBRT for lung metastases from any primary organs are available. Several reports (9,13,24,26-32) showed a high LC rate and low toxicity of SBRT/SABR for lung oligometastases from any primary cancer. The 1- and 2-year LC rate was 89.1–100% and 77.9–96%, respectively, and higher than Grade 2 pneumonitis was observed in 2.6–15%. In these reports, favorable PFS and OS were reported, although they were strongly influenced by primary site, chemotherapy before and after SBRT, and the definition of “oligometastases” in each institution. Hence, evaluating and interpreting SBRT benefits for survival is difficult to compare between these reports. However, the SABR-COMET phase II trial compared SBRT with standard-of-care palliative treatment and showed that SBRT improved the OS and PFS (33). Additionally, SABR improved patient-reported QOL (25). Hence, SBRT for lung oligometastases may improve LC, survival benefit, and QOLs. According to previous studies, long DFI (13,30,32,34), primary tumor histology (8,13,24,25,30), pretreatment performance status (8,13), maximum diameter (8,13), pre-SBRT chemo (8), and number of metastases (8,13) were associated with good prognosis.

As previously described, severe toxicities related to SBRT for peripheral lesions were reported to be rare. However, we sometimes experience severe toxicity, and especially radiation pneumonitis is a potentially fatal adverse event. Approximately 10% of SBRT patients develop have symptomatic pneumonitis which is greater than Grade 2 in CTCAE (35-37), Grade 3 pneumonitis and Grade 5 fatal respiratory toxicities were observed in 2–5% (36,38) and 0.02–0.9% patients (7,29,39), respectively. It is difficult to predict accurately which patients will develop severe lung toxicity. However, several factors were related to lung toxicity such as the big size of metastatic lesions (37,39,40), being female (37), smoking (37), being elderly (40), and high lung dose-volume exposure (37,40). Lesions bigger than 2–3 cm was associated with high risk (39,40). Additionally, previous reports of 3D-CRT for thoracic showed poor nutrition (41) and several kinds of concurrent chemotherapy such as concomitant carboplatin/paclitaxel (42), gemcitabine (43), and irinotecan (43) were associated with increased risk of radiation pneumonitis. In addition to radiation pneumonitis, stenosis or perforation of trachea/bronchus, rib fracture, perforation of the esophagus or gastric, bronchial plexopathy, pleural/ pericardial effusion, radiation dermatitis and spinal code injury are complications that may be related to SBRT.

Additionally, the location of lung metastases is important to avoid severe toxicity. If the tumor is centrally located, that is, within a 2 cm zone around the proximal bronchial tree, or if the PTV attached to the mediastinal or pericardial pleura (44), the risk of treatment-related severe adverse events such as pneumonitis, bronchial stenosis, pericardial effusion, dyspnea, and hemoptysis which sometimes cause death, is increased, and these complications may occur several months or years after SBRT (10,11). The previous reports showed that 20–33% of patients with central lesion will develop Grade 3–5 adverse events (10,11). However, though the risk of complication is higher in central lesions than in peripheral lesions, the tumor control rate is not different between central and peripheral lesions. The 2-year LC was 85.3–100% in both cases (11,45,46). However, several reports showed that SBRT can be administered for central lesions with a reduced complication rate (46-48). Although there is not sufficient evidence for the safe administration of SBRT in central lesions, centrally located metastases have the potential to affect the QOL such as severe cough, shortness of breaths, and in some cases, hemoptysis according to tumor progression. Therefore, EBRT in this area should be further investigated.

Radiation pneumonitis does not usually occur during the irradiation period. One report showed that the median time to diagnose radiation pneumonitis was 5 months (range: 1.5–9 months) (35). Therefore, continuous follow-up for symptoms is essential. If patients who were treated by SBRT complain of dry cough, shortness of breath, low-grade fever, or show a pulmonary infiltrate on chest X-ray, physicians should take radiation pneumonitis into consideration and examine further as needed. In addition to imaging modalities such as X-ray and computed tomography (CT), serum KL-6 is a useful predictive marker for the early detection of radiation pneumonitis (49,50).

Follow-up procedure after radiation therapy

Since SBRT causes lung changes such as radiation pneumonitis and radiation fibrosis scar of treated lesions, it is sometimes difficult to differentiate local recurrence from lung change. However, it is important to determine local recurrence, especially in patients who can be treated with further local therapy like re-irradiation, surgical resection, and radiofrequency ablation or systemic therapy. The success of local therapy may be interpreted differently by surgeons and radiation oncologists. The success of surgical resection defined as complete resection with an appropriate margin and no mass-like lesion observed on CT imaging after the operation. However, the success of SBRT is usually defined as “no progression of the tumors” on the follow-up CT, and the complete disappearance of lung metastases treated by SBRT is rare, although some degree of tumor shrinkage is often observed.

Although the rate of symptomatic radiation pneumonitis in patients treated with SBRT was low, 60–100% of patients reported some radiographic change with or without symptom (51). The shape of lung injury after SBRT is different from that after 3D-CRT, due to differences in dose distributions. The lung changes after 3D-CRT including adjuvant irradiation to the breast after conserving surgery is usually of “liner-edged shape” according to the dose contribution, and it is usually easy to recognize the shadow that occurs due to the irradiation effect. However, since the dose contribution is fitted to the target shape, the shape of lung injury after SBRT usually appears as a “mass-like shape” lesion on CT images, and it is sometimes difficult to differentiate lung change due to irradiation from local recurrence, especially in the early phase after SBRT (38,52). Previous reports (52-55) showed that mass-like shape lesions were observed in 40–68% of patients after SBRT, and of these, real malignant local recurrence occurred in only 11–23%. Hence, it is important to determine the natural course of lung change after SBRT using CT imaging.

The chest CT changes after SBRT reported previously are shown in Table 3. Radiographic changes are roughly divided into two types according to the time after SBRT: early radiological changes as ground-glass opacity or spotted condensation related to pneumonitis and chronic radiological changes as dense consolidation or retraction related with fibrosis (35). In the early phase after SBRT within the first 6 weeks, almost all patients have no radiographic change on CT (35), and after 1.5 months, radiographic changes become gradually distinct on CT images (38,57). From 3–6 months after SBRT, ground grass opacity or spotted streaky condensation sometimes appear near the treated metastases (35), and non-symptomatic radiation pneumonitis occurs most frequently at this time (38). From 7–9 months after SBRT, early changes that appeared in 3–6 months generally disappear or change to dense consolidation (35). Subsequently, dense consolidation changes both in size and appearance due to fibrotic processes such as shrinkage, retraction, or movement of shadow toward hilum or pleura (35,38,57). Usually, fibrotic changes appear within the high-dose irradiated area (35).

Table 3. Summarization of previous reports on radiographic change observed on CT after SBRT.

Months after SBRT	Early changes mainly caused by pneumonitis				Chronic changes mainly caused by fibrosis
	<1 months	1–3 months	3–6 months		7–9 months	10–12 months	>12 months
Radiographic change on CT	Almost no patient has a pulmonary reaction (35)	Tumor decrease in size is sometimes observed, and new GGO or spotted-streaky condensation near targets is observed (35)	Radiation pneumonitis without symptoms occur most frequently (38)			Consolidation moves toward hilum or pleura because of shrinking of the opacity and gradually shrank (35)	Fixed consolidation as solid or lined with opacities; fibrotic remodeling process continues for years
Characteristics of local recurrence	Because new lung changes sometimes occurred related to SBRT in the early phase after treatment, it is difficult to differentiate between local recurrence and pulmonary injury				The timing of almost local recurrence is identified (35,38)	Increasing size in consolidation after 12 months was highly suspected of local recurrence (52)
	Continuous regression for 3 times on CT with 3 months interval is highly suspected to have a local recurrence (54); findings of 18FDG-PET uptake and shape are useful for differentiation (55,56); malignant mass-like consolidation appears earlier in median 7 months than that of no malignancy in median 12 months (54)

CT, computed tomography; SBRT, stereotactic body radiation therapy; ¹⁸FDG-PET, ¹⁸F-fluorodeoxyglucose positron emission tomography.

It is difficult to differentiate between local recurrence and pulmonary injury. However, several previous reports demonstrated the usefulness of serial CT (52,54) and ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸FDG-PET) (55,56). On CT images, patients with continuous regression for 3 times at 3 months intervals (54) and an increase in the size of the lesion after 12 months (52,54) are highly suspected with local recurrence. Malignant mass-like consolidation appears in median 7 months which is earlier than that of no malignancy in median 12 months (54). On ¹⁸FDG-PET, maximum standardized uptake value (SUVmax) could differentiate local recurrence from pulmonary injury with the sensitivity and specificity of 100% and 96–98%, respectively (55). Another report showed that both SUVmax and a combination of uptake intensity of FDG with uptake shape: mass-like or non-mass-like, were useful predictors for differentiating local recurrence from radiation pneumonitis (56).

Problems associated with EBRT for lung oligometastases

As mentioned previously, SBRT for lung oligometastases was less invasive and had a comparable LC rate than surgical resection. Therefore, SBRT is widely used to treat lung oligometastases. However, it may sometimes lead to overtreatment or delay systemic therapy due to complications. Therefore, a multidisciplinary team and not an individual specialist should carefully determine whether the metastatic lesion is really “oligometastases”, whether the lesion should be treated by local therapy or systemic therapy, and the risk and expected benefits of these treatments.

Another disadvantage of SBRT is that the pathological findings cannot be obtained. Patients undergoing SBRT, especially non-operable patients, are sometimes diagnosed with lung metastases on CT series, without pathological proof. However, a previous report showed that 18% of surgically resected lung or brain lesions which were considered as oligometastatic lesions of NSCLC, were benign (58). Treating such patients with SBRT would needlessly add further systemic therapy in the absence of pathological findings.

Finally, in breast cancer patients with a history of irradiation to the conserved breast, chest wall, or subclavian area as adjuvant therapy after surgical treatment for primary lesions, especially in the case of lung metastases located near the apex of the lung and front chest, the previous irradiated area should be carefully checked before administration of further SBRT.

Future prospects of SBRT

Most reports described here are retrospective studies, and the survival benefit of SBRT for lung oligometastases is not truly established. Currently, a randomized phase II/III clinical trial for the evaluation of SBRT on PFS/OS is underway. For example, a search on Clinical Trials.gov (https://clinicaltrials.gov/) showed NCT02364557 which is a randomized phase II/III trial comparing standard-of-care therapy with or without SBRT and/or surgical ablation for newly oligometastatic breast cancer (NRG-BR002), NCT02759783 which is a phase II/III trial of comparing SBRT and the standard care for extracranial oligometastases from breast cancer, prostate cancer, and NSCLC, and NCT02089100 which is a phase III investigation evaluating SBRT for oligometastatic breast cancer.

Radiation therapy may affect both the irradiated site and the distant site, which is sometimes referred to as the abscopal effect (59,60). The most impressive case report of the abscopal effect for metastatic breast cancer was reported from Japan (61). In this report, a 64-year-old woman with breast cancer that had spread to multiple bones, lung metastases, and systemic lymph nodes metastases was treated with palliative radiation monotherapy for primary breast lesions, and some painful bone metastases without systemic therapy because of her poor performance status. However, 10 months after irradiation, her gross tumors had entirely disappeared on the ¹⁸FDG-PET scan, and this was strongly considered as an abscopal effect (61). Though such a remarkable abscopal effect is truly rare, radiation therapy was reported to enhance immune-mediated mechanisms (62,63). In stage III NSCLC, the use of adjuvant therapy with Durvalumab which is an immune checkpoint inhibitor (ICI), after concurrent chemoradiation significantly improves PFS (64), and this may be related to the enhanced immune-mediated system after radiation. Since there is no evidence for ICI monotherapy or a combination of radiation therapy and ICI in breast cancer, the immuno-effect of SBRT may have the potential of improving metastatic breast cancer treatment outcomes.

Conclusions

In conclusion, EBRT, especially SBRT/SABR, has high LC late with rare severe toxicity for lung oligometastatic breast cancer, and may potentially improve PFS and OS. Furthermore, SBRT may be able to cure oligometastatic patients. However, further investigation of oligometastatic patients is needed. In addition, the risk and expected merit of local therapy or systemic therapy should be discussed carefully by a multidisciplinary team.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.