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KD values derived from microscale thermophoresis analysis
| hIgG1 variants | KD (nM) pH 5.5 | KD (μM) pH 7.4 |
|---|---|---|
| ustekinumab | 497 ± 214 | NA |
| briakinumab | 599 ± 99 | >25 |
| ustekinumab-YTE | 100 ± 56 | NA |
| briakinumab-YTE | 79 ± 45 | >20 |
| ustekinumab/IL12 | 1000 ± 700 | NA |
| briakinumab/IL12 | 533 ± 65 | >10 |
| ustekinumab-YTE/IL12 | 78 ± 45 | >20 |
| briakinumab-YTE/IL12 | 98 ± 50 | >4 |
NA – not acquired due to negligible binding affinity.
The results are mean ± SD from two independent experiments performed in duplicates.
