Fig. 5.

Regulation of hippocampal synaptic plasticity by DON with or without GlcN. A Effect of DON on field excitatory postsynaptic potential (fEPSP) in hippocampal slices (n = 7, 78.3 ± 6.5%, p < 0.05). B Effect of GlcN on levels of synaptic activity measured as slope of fEPSPs in hippocampal slices (n = 11, 94 ± 5.0%, p > 0.2). C Effect of DON with or without GlcN on hippocampal LTP induction by 4xTBS (Ctrl., 150.1 ± 10.9%, p < 0.01; 100 μM DON, 121.6 ± 7.2%, p < 0.05; 100 μM DON + 5 mM GlcN, 148.6 ± 9.5%, p < 0.005). D Graph showing the magnitude of LTP by DON with or without GlcN (one-way ANOVA, p = 0.09, post hoc LSD). E Effect of DON with or without GlcN on hippocampal LTD induction by LFS (Ctrl., 71.1 ± 6.2%, p < 0.05; DON, 58.1 ± 10.8%, p < 0.05; DON + GlcN, 70.4 ± 8.4%, p < 0.05). F Graph presenting comparison of LTD magnitude (one-way ANOVA, p > 0.5). Scale bar, 20 ms, 0.2 mV