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. 2021 Dec 10;13(2 Suppl):1530S–1539S. doi: 10.1177/19476035211063857

Figure 5.

Figure 5.

Histomorphometrical effect of the reloading on the bone atrophy in medial tibia: (A and B) area of the cancellous and trabecular bones, (C) percentage of bone volume, (D) thickness of subchondral bone, and (E) representative histological findings. Scale bar = 2 mm. The cancellous bone was not affected by unloading or reloading, and trabecular bone was significantly decreased by unloading and showed an increasing trend with reloading. As a result, the bone volume was significantly reduced by unloading and recovered to the same level as that of the Con group after 2 weeks of reloading. Similarly, the thickness of the subchondral bone was also significantly reduced by unloading, but it took 4 weeks to recover to the level of the Con group. HS = hindlimb suspension; RL = reloading.