Table 3.
Synovial Fluid Concentrations of the Biological Markers in Patients with Early and End-Stage OA a .
| Marker | Early OA (KL Grade ≤2), Median (IQR) | End-Stage OA (KL Grade ≥3), Median (IQR) | P |
|---|---|---|---|
| IL-6, pg/mL | 55.63 (595.2) | 32.73 (142.47) | 0.5998 |
| IL-8, pg/mL | 4.80 (17.68) | 8.086 (10.44) | 0.5127 |
| MMP-1, pg/mL | 3670 (14898.0) | 9844 (18028) | 0.0861 |
| MMP-3, pg/mL | 25054 (28063.0) | 35705 (11358) | 0.0057** |
| MMP-13, pg/mL | 21.46 (16.86) | 58.42 (184.33) | 0.1978 |
| Adiponectin, ng/mL | 4350 (4439) | 1661 (4286) | 0.4856 |
| COMP, ng/mL | 3324 (3450) | 4601 (1806) | 0.0487* |
| Marker | Early OA (KL Grade ≤2), Mean ± SD | End-Stage OA (KL Grade ≥3), Mean ± SD | P |
| TIMP-1, pg/mL | 13520 ± 640.4 | 15920 ± 628.2 | 0.0240* |
| TIMP2, pg/mL | 8796 ± 919.4 | 6148 ± 1398 | 0.1144 |
OA = osteoarthritis; IL = interleukin; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of metalloproteinase; COMP = cartilage oligomeric matrix protein.
a
Values are expressed as median and interquartile ranges (IQR) or mean and standard deviation (SD). P values were calculated by using a Mann-Whitney U test or Student’s t test with 95% confidence interval. *P < 0.05 and **P < 0.01 was considered statistically significant.