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. 2022 Feb 1;13(1):e03044-21. doi: 10.1128/mbio.03044-21

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Copyright © 2022 Chiba et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Inhibitory effects of GS-441524 on SARS-CoV-2 replication in the lungs and nasal turbinate of hamsters. (A, B) Each group of hamsters (n = 4) was administered vehicle control or GS-441524 (25 mg/kg) as a prophylactic (days –1 to 3; twice/day) or therapeutic regimen (days 1 to 3; twice/day). The hamsters were intranasally inoculated with 10 or 1,000 PFU of SARS-CoV-2 (day 0). Infectious virus titers (PFU/g) in the lungs (panel A) and nasal turbinate (panel B) were examined by performing plaque assays. Dots and bars show the value for each animal and the average in each group, respectively (n = 4, mean ± SD). *, P < 0.05; NS, not significant; determined by a one-way analysis of variance (ANOVA) and corrected for multi-group comparison using Dunnett’s test.