Table 2.

The effects of high PR risk score on TIM

Immune cell	Changing trend	Basic function	Final effect on antitumor immune
T cells CD8	Decreased	CD8 + T cells clear tumor cells through perforin-granzyme and Fas-Fasl pathways.	Unfavorable
NK cells	Decreased	NK cells can kill multiple adjacent cells if these carry with oncogenic markers.	Unfavorable
Tregs	Increased	Tregs actively participate in the maintenance of immunological self-tolerance, thereby inducing cancer immune escape.	Unfavorable
Macrophages M0	Increased	TAMs can enhance tumor cell invasion and metastasis through secreting VEGF, CCL2, CXCL12, and EGF cytokines.	Unfavorable
Macrophages M1	Increased	M1 macrophages can mediate the differentiation of T cells and facilitate their immune functions through releasing IL-12 and IL-23.	Beneficial
Macrophages M2	Increased	M2 macrophages are the majority of TAMs, possessing immunosuppressive capacity and leading poor prognosis.	Unfavorable

PR, pyroptosis-related; TIM, tumor immune microenvironment; Tregs, regulatory T cells; TAMs, tumor-associated macrophages; VEGF, vascular endothelial growth factor; CCL2, C-C motif chemokine ligand 2; CXCL12, C-X-C motif chemokine ligand 12; EGF, epidermal growth factor.