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. 2022 Jan 14;13(1):1908–1920. doi: 10.1080/21655979.2021.2020396

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — CASP5 is a downstream target gene of miR-527 in HGFs.

(a) Bioinformatics predicted the binding sites between miR-527 and CASP5. Identification of the interaction between miR-527 and CAPS5 by dual-luciferase reporter assay (b) and RNA pull-down assay (c). CAPS5 expression levels in HGFs transfected with sh-circ_0138959 and antagomiR-527 (d), PDL tissues of patients with periodontitis (e), and LPS-treated HGFs (f). **P < 0.01, vs. agomiR-nc, biotin-nc, sh-nc, healthy, and control groups. ^##P < 0.01, vs. sh-circ_0138959+ antagomiR-nc group.