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. 2022 Jan 4;13(1):1459–1475. doi: 10.1080/21655979.2021.2019871

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Exosomes of PASP-PLGA microcapsules affected cartilage differentiation via Smad/RUNX2 signaling pathway. (a-b) The expression of Aggrecan, Collagen II, SOX-9 and TIMP-1 was detected by immunofluorescence and Western blot in vitro, respectively. (c-d) The expression of Aggrecan, Collagen II, SOX-9 and TIMP-1 was detected by immunohistochemistry and Western blot after treatment with exosomes of PASP-PLGA microcapsules in vivo, respectively. (e) The expression of Aggrecan, Collagen II, SOX-9 and TIMP-1 detected by immunofluorescence with BMP-2 knockdown in vitro. (f) The expression of Aggrecan, Collagen II, SOX-9 and TIMP-1 detected by Western blot with BMP-2 knockdown in vitro. **p < 0.01 vs. control-Exo group. The data were expressed as mean ± standard deviation.