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. 2022 Jan 3;13(1):1424–1435. doi: 10.1080/21655979.2021.2018974

Figure 4.

Figure 4.

MBNL1-AS1 was negatively correlated with the expression of miR-132-3p. (a) miR-132-3p was predicted to be the target of MBNL1-AS1 through DIANA database. (b) The expression level of miR-132-3p in heart tissues of sham and AMI rats (***P < 0.001). (c) The expression level of MBNL1-AS1 in H9c2 cells with or without treatment of hypoxia (***P < 0.001). (d) The expression level of miR-132-3p in H9c2 cells with or without treatment of hypoxia (***P < 0.001). (e) The luciferase activity of MBNL1-AS-WT or MBNL1-AS1-MUT was measured after transfecting miR-132-3p mimic (***P < 0.001). (f) The load of MBNL1-AS1 and miR-132-3p enriched by AGO2 or IgG. (g) The expression level of miR-132-3p was affected by knockdown or overexpression of MBNL1-AS1 (**P < 0.01, $P < 0.05).