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. 2021 Jan 11;12(1):369–381. doi: 10.1080/21655979.2020.1868742

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — MiR-146a-5p is the target of LINC00960 in PDAC

A. The luciferase reporter vectors LINC00960-WT, LINC00960-MUT1, LINC00960-MUT2, LINC00960-MUT3, and LINC00960-MUT1&2&3 were constructed.B. The miR-146a-5p mimics were co-transfected with LINC00960-WT, LINC00960-MUT1, LINC00960-MUT2, LINC00960-MUT3, or LINC00960-MUT1&2&3 into 293 T cells, respectively. Then the luciferase activity of the cells in each group was determined.C. Pearson’s correlation analysis showed that there was a negative correlation between LINC00960 expression and miR-146a-5p expressions in PDAC tissues.D. The expression of miR-146a-5p in BxPC-3 and Colo357 cells with LINC00960 knockdown was detected by qRT-PCR.E. RNA Pull-down assay was used to detect the binding relationship between LINC00960 and miR-146a-5p.F. RIP experiment was used to detect the binding relationship between LINC00960 and miR-146a-5p.** P < 0.01 and *** P < 0.001.